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African Horse Sickness (African Horsesickness)

An insect-borne reovirus infection of horses, mules and donkeys in Africa and the Middle East; characterized by pulmonary edema, cardiac involvement, and edema of the head and neck.
Also Known As:
African Horsesickness; African Horse Sicknesses; African Horsesicknesses; Equine Plagues; Horse Sickness, African; Horse Sicknesses, African; Horsesickness, African; Horsesicknesses, African; Plague, Equine; Plagues, Equine; Sickness, African Horse; Sicknesses, African Horse; Equine Plague
Networked: 53 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Vaccinia
2. Peste-des-Petits-Ruminants
3. Paramyxoviridae Infections (Parainfluenza)
4. Bluetongue
5. Infection

Experts

1. Guthrie, Alan J: 3 articles (10/2015 - 07/2007)
2. Lourens, Carina W: 2 articles (10/2015 - 07/2009)
3. MacLachlan, N James: 2 articles (10/2015 - 07/2007)
4. van Kleef, M: 1 article (02/2016)
5. Faber, F E: 1 article (02/2016)
6. Pretorius, A: 1 article (02/2016)
7. Grewar, John D: 1 article (10/2015)
8. Majiwa, Phelix O A: 1 article (10/2015)
9. Koekemoer, Otto: 1 article (10/2015)
10. van Schalkwyk, Antoinette: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to African Horse Sickness:
1. VaccinesIBA
2. Capsid Proteins (Capsid Protein)IBA
3. AntibodiesIBA
4. binary ethyleneimineIBA
5. Complement System Proteins (Complement)IBA
01/01/1992 - "These findings are important for the epidemiology of the African horse sickness in Nigeria just as the complement-fixing rates are in camels and dogs for the epidemiology of this sickness in the whole of Africa."
01/01/1975 - "[Adaptation of the complement fixation microtechnic to the diagnosis of equine plague]."
08/01/1988 - "During the nine years from October 1972 to September 1981 African horse sickness (AHS) virus was isolated from 23 suspected cases of the disease in Zimbabwe and complement fixation antibody titres indicative of recent infection were detected in a further 49 horses. "
05/02/1992 - "Low complement fixation titres were detected in all 4 patients to African horsesickness (AHS) virus and enzyme immunoassay and plaque reduction neutralising tests were positive, the latter against both serotypes 1 and 6. Five of 15 laboratory workers from the same facility who were healthy on clinical and ophthalmological examination showed positive plaque reduction neutralising tests but none to both serotypes 1 and 6. It is postulated that the encephalitis with the predominant temporal lobe involvement was caused by an airborne transnasal route of infection of the neurotropic AHS virus released in dried powder form, secondary to the accidental breaking of vaccine bottles. "
01/01/1990 - "Five serological methods of diagnosing African horse sickness were evaluated, using a battery of serum samples from experimental horses vaccinated and challenged with each serotype of African horse sickness virus (AHSV1 through AHSV9): agar gel immunodiffusion (AGID), indirect fluorescent antibody (IFA), complement fixation (CF), virus neutralization (VN), and enzyme-linked immunosorbent assay (ELISA). "
6. AntigensIBA
7. Immunoglobulin M (IgM)IBA
8. Formaldehyde (Formol)FDA Link
9. Viral AntigensIBA
10. AgarIBA