Adrenodoxin

An iron-sulfur protein which serves as an electron carrier in enzymatic steroid hydroxylation reactions in adrenal cortex mitochondria. The electron transport system which catalyzes this reaction consists of adrenodoxin reductase, NADP, adrenodoxin, and cytochrome P-450.

Also Known As:

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Bernhardt, Rita: 2 articles (07/2007 - 07/2005)
2.	Brixius-Anderko, Simoné: 1 article (01/2021)
3.	Scott, Emily E: 1 article (01/2021)
4.	Flück, Christa E: 1 article (01/2016)
5.	Legeza, Balazs: 1 article (01/2016)
6.	Ma, Nina S: 1 article (01/2016)
7.	Pandey, Amit V: 1 article (01/2016)
8.	Renthal, Nora: 1 article (01/2016)
9.	Zalewski, Adam: 1 article (01/2016)
10.	Buckpitt, Alan: 1 article (07/2007)

Related Diseases

1.	Hypotension (Low Blood Pressure) 07/01/2005 - "Because STS also causes hypotension, we investigated in this study whether it directly interferes with the terminal steps of aldosterone biosynthesis; these are catalysed by a mitochondrial steroid hydroxylase system consisting of adrenodoxin reductase, adrenodoxin, and the cytochrome P450 enzyme hCYP11B2 (aldosterone synthase). "
2.	Neoplasms (Cancer) 10/01/1976 - "Biosynthesis of adrenodoxin in mouse adrenal tumor cells." 03/14/1995 - "A full-length cDNA encoding mouse adrenodoxin was isolated from a Y1 adrenocortical tumor cell lambda ZAP cDNA library. " 03/03/1992 - "To define the sequences necessary for the synthesis of these two types of mRNA and to determine if the synthesis of each is driven by a separate promoter, 5'-regions of the adrenodoxin gene were inserted upstream from two different reporter genes and tested for promoter/enhancer regulatory activity by transient transfection into mouse adrenocortical Y1 tumor cells. "
3.	Choriocarcinoma 04/01/1992 - "Regulation of the cholesterol side-chain cleavage cytochrome P-450 and adrenodoxin mRNAs in cultured choriocarcinoma cells." 04/01/1992 - "We examined the effects of cholera toxin (CT), an activator of adenylate cyclase, and 12-O-tetradecanoylphorbol acetate (TPA), a phorbol ester protein kinase C activator, on the levels of mRNAs encoding P-450scc and adrenodoxin in JEG-3 choriocarcinoma cells. " 01/01/1989 - "The effects of 8-bromo-cAMP on alpha- and beta-hCG, adrenodoxin, and cytochrome P-450scc mRNAs, in cytotrophoblasts and JEG-3 choriocarcinoma cells, required the catalytic unit of protein kinases since H-7, a kinase inhibitor, blocked the increase in the mRNAs and prevented the stimulation of hCG and progesterone secretion. "
4.	Cerebrotendinous Xanthomatosis 11/15/1996 - "Genetic analysis of a Japanese cerebrotendinous xanthomatosis family: identification of a novel mutation in the adrenodoxin binding region of the CYP 27 gene."
5.	Whooping Cough (Pertussis) 06/01/1988 - "pertussis can be functionally integrated into the cAMP-dependent effector pathway of granulosa cells with a resulting increase in intracellular cAMP concentrations, augmented biosynthesis of progesterone and pregnenolone, enhanced synthesis of immunospecific cytochrome P-450scc and adrenodoxin, and synergistic interactions with a non-cAMP-dependent ovarian effector hormone (estradiol).(ABSTRACT TRUNCATED AT 250 WORDS)"

Related Drugs and Biologics

1.	Cytochrome P-450 CYP11B2 (CYP11B2)
2.	Ferredoxin-NADP Reductase (Adrenodoxin Reductase)
3.	Enzymes
4.	Cytochrome P-450 Enzyme System (Cytochrome P450)
5.	Steroid Hydroxylases
6.	Aldosterone
7.	Progesterone
8.	Cytochromes
9.	Small Interfering RNA (siRNA)
10.	1- (5- Isoquinolinesulfonyl)- 2- Methylpiperazine (H 7)