|1.||Neoplasm Metastasis (Metastasis)
|4.||Critical Illness (Critically Ill)
|5.||Kaposi Sarcoma (Kaposi's Sarcoma)
|1.||Schteingart, David E: 3 articles (07/2012 - 06/2007)|
|2.||Bertherat, Jérôme: 3 articles (04/2010 - 11/2002)|
|3.||Risbridger, Gail: 2 articles (07/2015 - 12/2014)|
|4.||Gold, Elspeth: 2 articles (07/2015 - 12/2014)|
|5.||Marino, Francesco Elia: 2 articles (07/2015 - 12/2014)|
|6.||Kebebew, Electron: 2 articles (12/2013 - 08/2002)|
|7.||Huang, Wen-Wen: 2 articles (02/2011 - 04/2009)|
|8.||Yang, Jai-Sing: 2 articles (02/2011 - 04/2009)|
|9.||Wu, Ping-Ping: 2 articles (02/2011 - 04/2009)|
|10.||Chung, Jing-Gung: 2 articles (02/2011 - 04/2009)|
|1.||Fas Ligand Protein (Fas Ligand)IBA
03/01/2005 - "Additional studies on MHC class II genotype and phenotype and the altered Fas/Fas ligand system in adrenal neoplasms may help to identify mechanisms of immune escape and suggest new diagnostic approaches."
03/01/2005 - "Therefore, MHC class II phenotype and genotype and expression patterns of the Fas/Fas ligand system were investigated in 24 adrenocortical tumors (n(Adenomas) = 14, n(Carcinomas) = 10) and an adrenal cancer cell line (NCI-H295). "
|2.||Apolipoproteins E (ApoE)IBA
05/01/2010 - "Multiple kinase inhibitors such as sorafenib provide targeted oncologic treatment and may be effective in treating advanced adrenal cancer."
01/01/1979 - "This novel autophosphorylating, cAMP-binding, protein kinase may be a characteristic of certain adrenal neoplasms."
06/01/1997 - "The recently cloned cyclin-dependent kinase inhibitor gene p57KIP2 is genomically imprinted and located on human chromosome 11p15.5. This region contains two other imprinted genes, insulin-like growth factor II (IGF-II) and H19, both of which seem to be implicated in adrenal neoplasms. "
|5.||sorafenib (BAY 43-9006)FDA Link
|7.||Mitotane (Lysodren)FDA Link
11/01/2015 - "Adrenal gland: Cancer target of mitotane identified."
02/05/2015 - "RRM1 modulates mitotane activity in adrenal cancer cells interfering with its metabolization."
12/01/2012 - "Management of adjuvant mitotane therapy following resection of adrenal cancer."
07/01/2012 - "Structural requirements for mitotane activity: development of analogs for treatment of adrenal cancer."
06/07/2007 - "Adjuvant mitotane therapy of adrenal cancer - use and controversy."
|8.||DNA (Deoxyribonucleic Acid)IBA
02/01/1992 - "Studies on pathological morphology, clinical features and nuclear DNA contents by flow cytometry in adrenal neoplasms."
01/01/2014 - "This is the first reported case with DNA analysis, which demonstrated the loss of heterozygosity (LOH) at the NF1 locus in the adrenal cancer, supporting the hypothesis of an involvement of the NF1 gene in the pathogenesis of ACC. "
08/25/1999 - "For all cases with amplifiable DNA, there was a 100% concordance rate for LOH between cytologic and histologic material, with at least 7 of the 10 cytologic samples originating from metastatic lesions and all of the surgical material originating from the primary adrenal neoplasm. "
02/01/1992 - "Pathological morphology, clinical features and nuclear DNA contents determined by flow cytometry (FCM) were studied in 11 cases of normal adrenals and 41 cases of adrenal neoplasms. "
11/01/1991 - "Cleavage with Hpa II after digestion with Bgl II showed that significantly more DNA was digested into low-molecular weight fragments in adrenal cancer and the normal adrenal gland than those in other normal tissues. "
|9.||Adrenocorticotropic Hormone (ACTH)FDA Link
06/01/1991 - "Ectopic sources have a gradient of less than 2. Patients with ACTH-independent Cushing's syndrome can be confidently evaluated with imaging techniques, such as CT or MRI, looking for adrenal neoplasm or the "normal to small" glands characteristic of micronodular adrenal dysplasia."
11/01/2002 - "We have observed that ectopic expression of the GIP-R is frequent in ACTH-Independent Macronodular Adrenal Hyperplasia (AIMAH), rare in benign adrenal adenoma (AA), but seems absent in Adrenal Cancer (AC). "
03/01/2004 - "In the adrenal cancer cell line H295R and in primary cultures from adrenocortical cells, ACTH (1 nM) and forskolin (10 micro M) effectively increased seladin-1/DHCR24 expression, confirming that seladin-1/DHCR24 is modulated by the ACTH/cAMP-driven pathway. "
06/01/1996 - " In the largest of these studies, 11 patients with inoperable adrenal cancer or ectopic adrenocorticotrophic hormone-secreting neoplasms received 5-22 mg/kg/day of RU-486 for 1-12 months. "
11/01/2013 - "Because steroid-secreting adrenal neoplasms are independent of the classical endocrine regulatory factors angiotensin II and ACTH, which are respectively suppressed by hyperaldosteronism and hypercortisolism, these lesions have long been considered as autonomous tissues. "
05/01/1995 - "According to the hormone profile, the next diagnostic step should be aimed at detecting a prospective ovarian or adrenal neoplasm."
10/01/1990 - "A 34-year-old man had a huge hormone-producing adrenal cancer with multiple lung metastases, direct liver invasion and a tumor thrombus in the inferior vena cava. "
08/01/1990 - "Suramin in adrenal cancer: modulation of steroid hormone production, cytotoxicity in vitro, and clinical antitumor effect."
12/01/2014 - "In conclusion, analysis of the inhibin/activin signalling pathway helps to explain discrepancies arising from studies of only one hormone or subunit and suggests that altered expression of the inhibin and activin subunits is associated with reproductive and adrenal cancer biology. "
10/01/1990 - "Successful treatment of a metastatic hormone-producing adrenal cancer by a combination of mitotane, tegafur and surgical resection."
10/01/2005 - " adrenalectomy is a safe and effective treatment for adrenal disorders, excluding primary adrenal cancer. "
11/01/1994 - "We conclude that laparoscopic adrenalectomy is a safe and effective, minimally invasive approach for patients with benign adrenal neoplasms."
01/01/2008 - "Open adrenalectomy has been the gold-standard therapy for adrenal neoplasms. "
12/01/2004 - "We review studies on the outcome of laparoscopic adrenalectomy for primary adrenal cancer as well as studies on metastatic disease to the adrenal glands. "
11/01/2001 - "The aim of this study was to compare the outcome of laparoscopic adrenalectomy (LA) performed for benign adrenal neoplasm to the open procedure in a similar group of patients. "
|2.||Drug Therapy (Chemotherapy)
11/01/2011 - "Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?"
12/01/2010 - "Expression of anti-apoptosis genes determines the response of adrenal cancer to apoptosis-inducing chemotherapy."
05/01/2008 - "All the other agents tested required much higher doses for effect, including mitotane, the current most commonly used chemotherapy for adrenal cancer, with an EC (50) of 3.3x10 (-4) M. "
10/01/1990 - "The present results, together with previous reports in the literature, seem to recommend the following therapeutic approaches to advanced adrenal cancer: monitoring of the serum level may be useful in predicting the efficacy as well as the occurrence of side effects of mitotane, surgical treatment of the lesions should be performed whenever possible, even though it may be only palliative, and the combination of mitotane and tegafur is a choice of chemotherapy which should be evaluated in future studies."
12/01/2005 - "Virilizing adrenal cancer and bail-out nephrectomy."
12/01/2005 - "We report a rare case of virilizing adrenal cancer with tumorous invasion of the left renal vein in which a retroperitoneal adrenalectomy with bail-out nephrectomy was performed. "
08/01/2004 - "Because renal or adrenal cancer was suspected, right adrenalectomy and nephrectomy were performed. "
10/01/2004 - "In the future, laparoscopic partial nephrectomy and the laparoscopic procedure for adrenal cancer and prostate cancer are considered to become widespread."
09/01/2005 - "We reported laparoscopic adrenalectomy for adrenal cancer, our experience of laparoscopic partial nephrectomy, radical prostatectomy, retroperitoneal lymph node dissection for testicular cancer. "
|5.||Colonic Pouches (S Pouch)