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Adrenocortical Hyperfunction (Adrenal Gland Hyperfunction)

Excess production of ADRENAL CORTEX HORMONES such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and/or ANDROSTENEDIONE. Hyperadrenal syndromes include CUSHING SYNDROME; HYPERALDOSTERONISM; and VIRILISM.
Also Known As:
Adrenal Gland Hyperfunction; Hyperadrenalism; Hyperfunction, Adrenal Gland; Hyperfunction, Adrenocortical; Hyperadrenocorticism; Hypercorticism
Networked: 785 relevant articles (34 outcomes, 76 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Diabetes Mellitus
2. Pituitary Neoplasms (Pituitary Adenoma)
3. Neoplasms (Cancer)
4. Insulin Resistance
5. Cushing Syndrome

Experts

1. Neiger, R: 10 articles (01/2014 - 06/2002)
2. Kooistra, H S: 10 articles (11/2013 - 06/2002)
3. Mol, J A: 10 articles (07/2008 - 06/2002)
4. Rijnberk, A: 10 articles (05/2007 - 01/2001)
5. Reusch, C E: 9 articles (09/2016 - 07/2006)
6. Ramsey, I K: 9 articles (03/2011 - 07/2002)
7. Meij, B P: 7 articles (05/2012 - 01/2001)
8. Behrend, Ellen N: 7 articles (05/2011 - 05/2005)
9. Sako, Toshinori: 6 articles (07/2022 - 07/2003)
10. Boretti, F S: 6 articles (09/2016 - 07/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adrenocortical Hyperfunction:
1. trilostaneFDA Link
2. Adrenocorticotropic Hormone (ACTH)FDA Link
10/01/1998 - "In dogs with NAI, the AUC was 6.23 +/- 0.62 x 10(5) pg x min/mL, MRT was 38.7 +/- 12 min, the apparent elimination rate constant (k(el)) was 0.26 +/- 0.0017 min(-1) elimination half-life was 26.7 min, ClB was 0.84 +/- 0.1 x 10(4) mL/min/kg, and Vd(area) was 31.9 +/- 5.7 L/kg. In dogs with HAC, AUC was 4.74 +/- 0.23 x 10(5) pg x min/mL, MRT was 20.4 min, k(el) was 0.034 +/- 0.009 min(-1), half-life was 20.4 min, CIB was 1.06 +/- 6.0 x 10(4) mL/min/kg and Vd(area) was 29.7 +/- 6.7 L/kg. Dogs with pituitary-dependent hyperadrenocorticism showed more rapid elimination and clearance of exogenous corticotropin than dogs with NAI."
03/01/2011 - "This retrospective study was performed to investigate the diagnostic efficacy of the chemiluminometric ACTH-measurement to differentiate between pituitary and adrenal dependent hyperadrenocorticism (HAC) in dogs. "
03/01/2011 - "[Diagnostic efficacy of plasma ACTH-measurement by a chemiluminometric assay in canine hyperadrenocorticism]."
10/01/1998 - "The total body clearance of ACTH (ClB) was 1.83 +/- 0.46 x 10(4) mL x min/kg and volume of distribution (Vd(area)) was 30 +/- 15 L/kg. Corticotropin pharmacokinetics was also assessed in 12 client owned dogs, six dogs with non adrenal illness (NAI) and six dogs with hyperadrenocorticism (HAC), receiving exogenous ACTH (0.5 U/kg, i.v.). "
12/15/2009 - "Results of the study are discussed with reference to the treatment strategy chosen for the management of ACTH-dependent hypercorticism and the outcome of surgical intervention. "
3. Mitotane (Lysodren)FDA Link
4. Hydrocortisone (Cortisol)FDA LinkGeneric
5. Adrenal Cortex Hormones (Corticosteroids)IBA
6. GlucocorticoidsIBA
7. Glucose (Dextrose)FDA LinkGeneric
8. Desoxycorticosterone Acetate (DOCA)FDA Link
9. Cyproheptadine (Periactin)FDA Link
10. imidaclopridIBA

Therapies and Procedures

1. Hypophysectomy
2. Adrenalectomy
3. Therapeutics
4. Radiotherapy
5. Glycemic Control