Immunologic Adjuvants (Immunologic Adjuvant)
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Also Known As:
Immunologic Adjuvant; Immunological Adjuvant; Immunostimulants; Adjuvants, Immunologic; Adjuvant, Immunologic; Adjuvants, Immunological; Adjuvant, Immunological; Immunological Adjuvants; Immunoactivators; Immunoadjuvant; Immunoadjuvants; Immunopotentiator; Immunopotentiators; Immunostimulant
Networked: 1443
relevant articles (124 outcomes,
211 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Experts
1. | Chen, Wei R:
17 articles
(01/2022 - 01/2002)
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2. | Monneret, Guillaume:
11 articles
(04/2019 - 02/2013)
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3. | Nordquist, Robert E:
10 articles
(01/2021 - 01/2002)
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4. | Ragupathi, Govind:
9 articles
(04/2016 - 11/2003)
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5. | Zhou, Feifan:
8 articles
(01/2022 - 06/2009)
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6. | Hotchkiss, Richard S:
8 articles
(07/2021 - 03/2013)
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7. | Venet, Fabienne:
8 articles
(04/2019 - 08/2013)
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8. | Livingston, Philip O:
8 articles
(01/2012 - 05/2002)
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9. | Liu, Hong:
8 articles
(05/2011 - 01/2002)
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10. | Ito, Atsuo:
7 articles
(07/2020 - 06/2013)
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Related Diseases
1. | Neoplasms (Cancer)
12/01/2019
- " According to the recent studies, TLRs agonists are effective immunostimulants and have important role in induction of immune responses with immunotherapeutic potential against several diseases including cancer. " 01/01/1983
- " There are many immunopotentiators which showed potent antitumor activity in experimental tumor systems in vivo and in vitro, however, which were not always effective in well-designed controlled clinical trials. " 08/28/2020
- " To address the limitations of tumor penetration and distribution, and to enhance antitumor efficacy of immunotherapeutics, we present here an autonomous active microneedle (MN) system for the direct intratumoral (IT) delivery of a potent immunoadjuvant, cowpea mosaic virus nanoparticles (CPMV) in vivo. " 11/15/1975
- " parvum was not as effective in T-cell deprived as in control mice, which suggests that in this system, T-cells are required for optimal anti-tumor activity of this immunostimulant. " 06/01/1976
- " These data, which show that a change in route of drug administration or in the type of tumor treated may reverse the effect of treatment, emphasize that the mechanism of action of immunopotentiators must be elucidated before consistent beneficial treatment of tumor viruses or tumors can be achieved."
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2. | Infections
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3. | Influenza in Birds (Avian Flu)
11/01/2023
- " The recently detected clade 2.3.4.4 of the highly pathogenic avian influenza (HPAI) H5N8 virus in poultry encouraged us to study the efficacy of the 6 most extensively used saleable H5 poultry vaccinations (bivalent [AI + ND], Re-5 H5N1, H5N1, H5N3, monovalent AI, monovalent ND) with or without aqueous 8% neem (Azadirachta indica) leaf extract as an immunostimulant. " 10/01/2020
- " Immunostimulant effect of a mixed herbal extract on infectious bursal disease virus (IBDV) vaccinated chickens in the context of a co-infection model of avian influenza virus H9N2 and IBDV." 04/01/2019
- " Avian influenza virus (AIV) H9N2 infection causes economic losses on poultry farms, and immunostimulants are essential for improving chicken immunity. " 01/01/2017
- " We previously described that immunopotentiators, CVCVA5, increased the efficacy of H5 and H9 subtype avian influenza vaccines in chickens, ducks, and geese. " 06/24/2011
- " Immunoadjuvant efficacy of plasmids with multiple copies of a CpG motif coadministrated with avian influenza vaccine in chickens."
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4. | Communicable Diseases (Infectious Diseases)
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5. | Virus Diseases (Viral Diseases)
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Related Drugs and Biologics
Related Therapies and Procedures