Adie Syndrome

A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279)

Also Known As:

Adie's Syndrome; Poorly Reacting Pupils; Holmes Adie Syndrome; Poorly Reacting Pupil; Pupil, Poorly Reacting; Pupils, Poorly Reacting; Syndrome, Adie; Syndrome, Adie's; Syndrome, Holmes-Adie; Holmes-Adie Syndrome

Networked: 35 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Gingivitis
2.	Tonic Pupil
3.	Anisocoria
4.	Oculomotor Nerve Diseases (Oculomotor Nerve Palsy)
5.	Small Cell Lung Carcinoma (Small Cell Lung Cancer)

Experts

1.	Buso, Luciano: 1 article (11/2021)
2.	Coutinho Rodrigues, Danielle: 1 article (11/2021)
3.	De Campos, Deivis: 1 article (11/2021)
4.	Gowda, Sunil: 1 article (01/2021)
5.	Kawali, Ankush: 1 article (01/2021)
6.	Mahendradas, Padmamalini: 1 article (01/2021)
7.	Mutalik, Deepashri: 1 article (01/2021)
8.	Sanjay, Srinivasan: 1 article (01/2021)
9.	Shetty, Rohit: 1 article (01/2021)
10.	Barisic Kutija, Marija: 1 article (06/2017)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adie Syndrome:

1.	Prednisone (Sone)FDA LinkGeneric 05/01/1997 - "Prednisone and antimalarial drugs were ineffective in treating Adie syndrome but improved the necrotizing gingivitis. "
2.	Antimalarials (Antimalarial Agents)IBA 05/01/1997 - "Prednisone and antimalarial drugs were ineffective in treating Adie syndrome but improved the necrotizing gingivitis. "
3.	Pilocarpine (Ocusert)FDA LinkGeneric 06/01/1997 - "The 0.1% pilocarpine test confirmed a diagnosis of Adie's syndrome. " 12/01/1984 - "A symptomatic patient with Adie's syndrome is described as successfully managed with pilocarpine 0.125% applied topically to the involved eye three times daily. " 01/01/1977 - "In most patients with Adie's syndrome the ciliary muscle was supersensitive to pilocarpine 0..." 01/01/1985 - "Our study suggests those patients with Adie's Syndrome who lack stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity improves following a single drop of 0.1% pilocarpine. " 01/01/1985 - "Impressed by the benefit two patients with Adie's Syndrome derived from topical 0.1% pilocarpine therapy, we performed the present study to examine the measurable effects of 0.1% pilocarpine in several patients with this syndrome. "
4.	Methacholine Chloride (Methacholine)FDA Link 09/01/1982 - "In order to examine the clinical usefulness of methacholine in assessing the site of ocular parasympathetic lesions, pupillary responses in man were measured in postganglionic (Adie's syndrome) and preganglionic third nerve lesions involving the pupil and in controls. " 10/01/1965 - "Adie's syndrome: duration of methacholine sensitivity." 12/01/1953 - "Adie's syndrome and the Adler-Scheie mecholyl test." 09/01/1982 - "Methacholine pupillary responses in third nerve palsy and Adie's syndrome." 09/01/1982 - "Plasma cyclic nucleotide responses to methacholine in patients with Adie's syndrome."
5.	Cholinergic Agents (Cholinergics)IBA 09/01/1998 - "Comparison of cholinergic supersensitivity in third nerve palsy and Adie's syndrome." 12/01/1993 - "The finding of cholinergic supersensitivity in the iris muscles of patients with harlequin syndrome indicates a relationship with Holmes-Adie syndrome, Ross's syndrome, and the persistent autonomic deficit occasionally associated with Guillain-Barré syndrome." 08/01/2014 - "We report a 37-year-old woman with uveitic phase of Vogt Koyanagi Harada disease and tonic pupil, the tonic pupil persisted after other clinical features of this syndrome had disappeared; neurological evaluation shows absent knee and arm tendon reflexes and positive cholinergic supersensitivity test with Pilocarpine 0.125% confirming the diagnosis of Holmes Adie Syndrome."
6.	AntibodiesIBA 12/31/1977 - "A search for serum antibodies in Adie's syndrome." 01/11/2005 - "Anti-Hu antibodies, sensory neuropathy, and Holmes-Adie syndrome in a patient with seminoma." 06/01/2017 - "Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal-specific Hu proteins that are abnormally expressed in small-cell lung cancer (SCLC). "
7.	Fluorescein (Funduscein)FDA LinkGeneric 04/01/1983 - "In senile iris atrophies, Adie's syndrome and congenital albinism the iris vascular structure is basically normal, but atrophy of the iris stroma may lead to increased fluorescein permeability in the elderly."
8.	Thyroid HormonesIBA 11/03/2021 - "On this detail, this Letter presents unprecedented pieces of evidence that the anisocoria represented in Mona Lisa may be an indicator that Lisa del Giocondo had a neurological disorder known as Holmes-Adie Syndrome, which could have been caused by an endocrine disruption of the thyroid hormones. "
9.	Retinaldehyde (Retinal)IBA 01/01/2021 - "Coronavirus disease (COVID-19) can be associated with ophthalmic manifestations like conjunctivitis, retinal haemorrhages, retinal vascular occlusions, papillophlebitis, and Adie's syndrome. "
10.	Proteins (Proteins, Gene)FDA Link 06/01/2017 - "Adie's syndrome (AS) and paraneoplastic sensorimotor neuropathy with cerebellar ataxia (PSN CA) are extremely rare, rapidly progressive, autoimmune diseases associated with the development of antibodies against neuronal-specific Hu proteins that are abnormally expressed in small-cell lung cancer (SCLC). "

Therapies and Procedures

1.	Therapeutics 12/01/1984 - "Alternate approaches to the therapy of Adie's syndrome are mentioned. " 11/10/1977 - "[Differential diagnosis and therapy in Adie's syndrome]." 01/01/1975 - "[The clinical picture and therapy of patients with Adie's syndrome]." 01/01/1969 - "[Therapy of Adie's syndrome]." 01/01/1985 - "Our study suggests those patients with Adie's Syndrome who lack stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity may benefit from long term therapy with dilute pilocarpine if their stereoacuity improves following a single drop of 0.1% pilocarpine. "
2.	Denervation 02/01/1998 - "This study aimed to analyze the denervation and reinnervation history of individual segments of the iris sphincter in patients with Adie's syndrome. " 01/01/2017 - "Asymptomatic Severe Vagal and Sympathetic Cardiac Denervation in Holmes-Adie's Syndrome." 02/01/1965 - "PROGRESSIVE SUDOMOTOR DENERVATION AND ADIE'S SYNDROME." 11/01/1958 - "Progressive selective sudomotor denervation; a case with coexisting Adie's syndrome." 02/01/1998 - "A total of 61 patients with Adie's syndrome or Adie's-like denervation of the iris sphincter (from surgery, trauma, or radiation) and 10 normal subjects were studied. "
3.	Anesthesia 04/01/2015 - "Anisocoria after anesthesia induction caused by Adie syndrome." 09/01/2012 - "This article reports the case of a patient with known Adie's syndrome where anisocoria led to an unnecessary immediate interruption of anesthesia. "
4.	General Anesthesia 02/01/2008 - "Adie syndrome associated with general anesthesia."