Adenylosuccinate Lyase

An enzyme that, in the course of purine ribonucleotide biosynthesis, catalyzes the conversion of 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole to 5'-phosphoribosyl-4-carboxamide-5-aminoimidazole and the conversion of adenylosuccinic acid to AMP. EC 4.3.2.2.

Also Known As:

Networked: 48 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Zhang, Qing: 2 articles (01/2020 - 11/2019)
2.	Zurlo, Giada: 2 articles (01/2020 - 11/2019)
3.	Colman, Roberta F: 2 articles (03/2011 - 12/2004)
4.	Dewulf, Joseph P: 1 article (01/2022)
5.	Marie, Sandrine: 1 article (01/2022)
6.	Nassogne, Marie-Cécile: 1 article (01/2022)
7.	Al-Malki, Esam S: 1 article (12/2021)
8.	Chen, Yang: 1 article (09/2021)
9.	Du, Kechen: 1 article (09/2021)
10.	Li, Jie: 1 article (09/2021)

Related Diseases

1.	Severe combined immunodeficiency due to adenosine deaminase deficiency 12/01/1996 - "Moreover, several enzyme mutations of purine nucleotide metabolism are also clinically important including gout with hyperactive HPRT and the deficiency of HPRT (Lesch-Nyhan syndrome), adenylosuccinate lyase, xanthine oxidase, APRT, PNP, or ADA (SCID) with gene therapy." 09/01/2014 - "At present, treatments for the clinically significant defects of the purine pathway are restricted: purine 5'-nucleotidase deficiency with uridine; familial juvenile hyperuricaemic nephropathy (FJHN), adenine phosphoribosyl transferase (APRT) deficiency, hypoxanthine phosphoribosyl transferase (HPRT) deficiency and phosphoribosyl-pyrophosphate synthetase superactivity (PRPS) with allopurinol; adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiencies have been treated by bone marrow transplantation (BMT), and ADA deficiency with enzyme replacement with polyethylene glycol (PEG)-ADA, or erythrocyte-encapsulated ADA; myeloadenylate deaminase (MADA) and adenylosuccinate lyase (ADSL) deficiencies have had trials of oral ribose; PRPS, HPRT and adenosine kinase (ADK) deficiencies with S-adenosylmethionine; and molybdenum cofactor deficiency of complementation group A (MOCODA) with cyclic pyranopterin monophosphate (cPMP). "
2.	Body Weight (Weight, Body) 10/01/2019 - "Thus, this study aimed to investigate the effects of genes encoding melanocortin 4 receptor (MC4R), calpain 1 (CAPN1), and adenylosuccinate lyase (ADSL) on body weight, muscle fiber, and content of purine and its derivatives (i.e., adenine, guanine, hypoxanthine, and xanthine), to develop molecular markers for breeding programs. "
3.	Molybdenum cofactor deficiency 09/01/2014 - "At present, treatments for the clinically significant defects of the purine pathway are restricted: purine 5'-nucleotidase deficiency with uridine; familial juvenile hyperuricaemic nephropathy (FJHN), adenine phosphoribosyl transferase (APRT) deficiency, hypoxanthine phosphoribosyl transferase (HPRT) deficiency and phosphoribosyl-pyrophosphate synthetase superactivity (PRPS) with allopurinol; adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) deficiencies have been treated by bone marrow transplantation (BMT), and ADA deficiency with enzyme replacement with polyethylene glycol (PEG)-ADA, or erythrocyte-encapsulated ADA; myeloadenylate deaminase (MADA) and adenylosuccinate lyase (ADSL) deficiencies have had trials of oral ribose; PRPS, HPRT and adenosine kinase (ADK) deficiencies with S-adenosylmethionine; and molybdenum cofactor deficiency of complementation group A (MOCODA) with cyclic pyranopterin monophosphate (cPMP). "
4.	Autistic Disorder (Autism) 12/18/1995 - "Adenylosuccinate lyase (ADSL) and infantile autism: absence of previously reported point mutation." 12/17/2004 - "An Australian patient with autism was found to be heterozygous for two mutations in the gene encoding adenylosuccinate lyase (ASL), resulting in the protein mutations E80D and D87E. " 04/01/1996 - "Crystallization and preliminary structural analysis of Bacillus subtilis adenylosuccinate lyase, an enzyme implicated in infantile autism." 11/09/1989 - "Residual adenylosuccinase activity was studied in cultured lymphoblasts from a pair of siblings with infantile autism who have been previously shown to have a deficiency of the enzyme. " 01/01/1989 - "We have studied the residual adenylosuccinate lyase activity in cultured lymphoblasts from a pair of siblings with infantile autism who have been previously shown to have a deficiency of the enzyme. "
5.	Neoplasms (Cancer) 10/01/1998 - "Adenylosuccinate lyase (ASL, EC 4.3.2.2) is known to increase in malignancies such as colorectal, breast, and prostate cancer. " 05/15/1976 - "Increased adenylosuccinase activity in hepatomas and kidney tumors." 10/01/1987 - "Adenylosuccinate lyase as an indicator of breast and prostate malignancies: a preliminary report." 01/01/1981 - "L-5178Y/AR tumor, small intestine, liver, and lung, which were more susceptible to damage by L-alanosine, showed high concentrations of the putative active antimetabolite of L-alanosine, "L-alanosyl-AICOR", and either high concentrations of SAICAR synthetase, which forms this conjugate or low specific activities of adenylosuccinate lyase, the enzyme believed to decompose it. "

Related Drugs and Biologics

1.	purine
2.	Hypoxanthine
3.	Adenine
4.	Enzymes
5.	Ribose (D-Ribose)
6.	Hypoxanthine Phosphoribosyltransferase (Hypoxanthine Guanine Phosphoribosyltransferase)
7.	Adenosine Deaminase
8.	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)
9.	Xanthine
10.	Uridine

Related Therapies and Procedures

1.	Bone Marrow Transplantation (Transplantation, Bone Marrow)
2.	High-Protein Diet