Adenoviridae Infections (Adenovirus Infections)

01/01/2013 - "The efficacy of commonly used drugs to treat adenovirus infections (i.e., cidofovir in most cases) is limited, and alternative treatment options are needed. "
01/01/2019 - "The early administration of Cidofovir could be beneficial for the treatment of adenovirus infection in immunocompetent patients."
03/01/2001 - "Further studies in immunocompromised patients will be needed to extend these promising results concerning the role of cidofovir in adenovirus infection."
01/01/2020 - "Further study is warranted to determine the potential role of cidofovir in treating severe adenovirus infections in immunocompetent children."
11/27/2023 - "Safety of Cidofovir Treatment for Suspected or Confirmed Adenovirus Infection in Immunocompetent Pediatric Population."

08/11/2021 - "Efficacy of Brincidofovir in Pediatric Stem Cell Transplant Recipients With Adenovirus Infections."
01/01/2015 - "Brincidofovir, under development by Chimerix, Inc., is being evaluated against adenovirus infections in transplant patients including allo-HSCT patients in a phase III clinical trial (AdVise Study). "
09/01/2021 - "Rapid Virologic Response to Brincidofovir in Children with Disseminated Adenovirus Infection."
01/01/2019 - "Successful Brincidofovir Treatment of Metagenomics-detected Adenovirus Infection in a Severely Ill Signal Transducer and Activator of Transcription-1-deficient Patient."
01/01/2018 - "This is the first publication, to our knowledge, to describe two cases in which brincidofovir was used to successfully treat adenovirus infection in intestinal transplant recipients. "

01/01/2007 - "This prompted the search for antiviral agents effective against adenovirus infections. "
10/16/2023 - "This study aims to describe a new antiviral treatment option from the perspective of anti-adenovirus-mediated oxidative stress and its associated apoptosis and to provide theoretical guidance for the treatment of clinical adenovirus infection to a certain extent."
01/01/2022 - "Through this study, the newly identified adenovirus inhibitors may provide a start point for developing new antiviral drugs to treat adenovirus infections. "
01/27/2022 - "These results suggest that antiviral strategies that aim to degrade the primary receptor for apical adenovirus infection will be effective within a relatively short time frame after application."
01/01/2022 - "To identify potential antiviral agents for adenovirus infections, we screened a drug library containing 2138 compounds, most of which are drugs with known targets and past phase I clinical trials. "

01/01/2005 - "If our in vitro findings are predictive of virological responses in vivo, these results suggest that ribavirin would not be effective for management of non-C species adenovirus infections after HSCT."
04/01/2016 - "The patient was further treated with ribavirin and adenovirus-specific cytotoxic T lymphocytes but experienced multisystem progression of adenovirus infection culminating in death."
01/01/2004 - "In conclusion, the possible efficacy of intravenous Ribavirin in controlling RSV or adenovirus infections after allogeneic stem cell transplantations should be evaluated in prospective clinical trials."
12/01/2003 - "Oral ribavirin for severe adenovirus infection after allogeneic marrow transplantation."
03/01/1998 - "Failure of intravenous ribavirin in the treatment of invasive adenovirus infection following allogeneic bone marrow transplantation: a case report."

10/01/1996 - "Mutants of adenovirus type 2 fiber in this study were expressed in human cells by use of a recombinant vaccinia virus expression system that yielded protein indistinguishable from the fiber produced during adenovirus infection. "
01/01/2023 - "Importantly, we show that adenovirus infection leads to a reduction of the quantity and/or enzymatic activity of the APOBEC3B protein depending on the strains. "
05/01/2018 - "Following adenovirus infection, apoptosis of the SGNs was evaluated and Epo protein expression was assessed. "
01/01/2018 - "We show here that adenovirus infection and Ad-mediated gene delivery can be enhanced by inhibitors of bromodomain and extra-terminal (BET) family proteins. "
01/01/2018 - "Because protein-protein interactions are central to virus replication, identification of proteins interacting with protein VIII may help in understanding their role in adenovirus infection. "

10/01/2021 - "MAGI-1 PDZ2 Domain Blockade Averts Adenovirus Infection via Enhanced Proteolysis of the Apical Coxsackievirus and Adenovirus Receptor."
06/01/2015 - "Expression of an engineered soluble coxsackievirus and adenovirus receptor by a dimeric AAV9 vector inhibits adenovirus infection in mice."
03/01/2015 - "Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?"
01/01/2015 - "The localization of their receptors coxsackievirus and adenovirus receptor, and desmoglein-2 in cell-cell junction complexes between polarized epithelial cells represents a major challenge for adenovirus infection from the apical surface. "
03/06/2014 - "Coxsackie and adenovirus receptor (CAR) is essential for adenovirus infection to target cells, and its constitutive expression in various cancerous and normal tissues has been reported. "

03/01/1981 - "[Cytochemical study of granulocyte enzymes in germ-free animals with adenovirus infections]."
01/01/2007 - "Restriction enzyme analysis of the adenoviral genome is currently the most widely used procedure for the characterization of adenovirus isolates and has been extensively used for molecular epidemiological studies of subspecies B1 adenovirus infections. "
11/01/2001 - "GFAT1 and GFAT1Alt expressed by recombinant adenovirus infection in COS-7 cells displayed robust enzyme activity and kinetic differences. "
07/01/1989 - "Enzyme immunoassay and IF were equally sensitive (P = 0.5), with sensitivities of 80.6 and 79.0%, respectively, when swab specimens were collected from patients within 7 days of the onset of clinical symptoms of adenovirus infection. "
04/01/1988 - "A new, direct, enzyme immunoassay test (Adenoclone, Cambridge BioScience, Hopkinton, MA) was evaluated for the rapid diagnosis of ocular adenovirus infections. "

07/01/1978 - "[Study of the effect of myxovirus and adenovirus infections on the level of serum immunoglobulins in infants aged 1-36 months]."
03/01/1982 - "Concentrations of serum immunoglobulins and the number of B-lymphocytes in the peripheral blood were determined in herpes and adenovirus infections of the eyes. "
06/01/1977 - "[Obtaining group-specific fluorescent immunoglobulin for diagnosis of adenovirus infection]."
09/01/1975 - "[Diagnosis of adenovirus infection in man using Fitz-immunoglobulins to whole virion and to the purified hexone component (author's transl)]."
11/01/1969 - "Immunoglobulin responses in serum and nasal secretions after natural adenovirus infections."

05/15/1997 - "Adenovirus infection leads to increased apoptosis by the mitotoxin due to enhanced internalization of the ligand-receptor complex and release of the active toxin from the endosomes."
01/01/2019 - "Notch ligand-expressing adenovirus infection enhances the efficacy of dendritic cell-based immunotherapy for allergic asthma in mice."
03/21/2014 - "Harboring sCAR-ligand expression cassette in the viral genome may provide a universal method to redirect oncolytic adenoviruses to various membrane receptors on cancer cells resisting serotype 5 adenovirus infection. "
09/01/2010 - "Our data showed that intrahepatic V(alpha)14iNKT cells were activated in response to adenovirus infection to induce significant levels of hepatic chemokine (C-C motif) ligand 5 (CCL5) and subsequent liver toxicity. "
05/18/2009 - "We compared the transduction efficiency of AAV2 vectors with an AAV2 capsid (AAV2/2) to AAV2 vectors pseudotyped with AAV5 (AAV2/5), AAV8 (AAV2/8) or bovine adeno-associated virus (BAAV) capsids, or an AAV2 capsid with an insertion of the low density lipoprotein receptor ligand from apolipoprotein E (AAV2apoE), on cultured islets, in the presence of helper adenovirus infection to speed expression of a GFP transgene. "

01/01/2000 - "Recent advances in adeno-associated virus (AAV) vector production have eliminated the need for adenovirus infection by transfection of plasmids encoding the adenovirus E2A, E4orf6, and VA RNA transcription units. "
12/01/1989 - "These EVA cell lines may be of use to study the mechanism of VA RNA function in the absence of adenovirus infection."
07/01/1998 - "Therefore the minimum set of genes required to produce AAV helper activity equivalent to that provided by adenovirus infection consists of, or is a subset of, the following genes: the E4orf6 gene, the 72-M(r), E2A protein gene, the VA RNA genes and the E1 region. "
12/01/1989 - "These results directly show that the primary function of VAI RNA in the lytic adenovirus infection is the inhibition of eIF-2 alpha phosphorylation by DAI kinase and identify eIF-2 alpha as the target that mediates the effects of DAI kinase activation. "
09/15/1997 - "TDF is selectively inactivated during protein synthesis inhibition by cycloheximide and at a late stage of adenovirus infection, thus accounting for the loss of RNA Pol III-mediated transcription of the tRNA and VA RNA genes under these conditions. "

02/01/2007 - "Improved outcome from invasive adenovirus infection in pediatric patients after hemopoietic stem cell transplantation using intensive clinical surveillance and early intervention."
11/01/2010 - "This study provides a rationale and strategy for the adoptive transfer of donor-derived human adenovirus hexon-specific CD8(+) and CD4(+) T cells for the treatment of disseminated adenovirus infection after allogeneic stem cell transplantation."
10/01/2021 - "[Adoptive immunotherapy for uncontrolled adenovirus infection after allogeneic stem cell transplantation]."
01/01/2021 - "Virus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted."
02/01/2020 - "Transfer of Hexon- and Penton-selected adenovirus-specific T cells for refractory adenovirus infection after haploidentical stem cell transplantation."

01/01/2023 - "Collectively, our study provides new detailed insights about the HAdV-host interactions, which might be helpful when developing countermeasures against pathogenic adenovirus infections and for improving adenovirus-based therapies."
08/26/2010 - "Our study changes the longstanding definition of how p53 is inactivated in adenovirus infection and provides key insights that could enable the development of true p53-selective oncolytic viral therapies."
03/15/2001 - "Experiences with 2889 adult BMT recipients were reviewed to study the incidence, clinical spectrum, risk factors for dissemination, response to therapy, and outcome of adenovirus infections. "
01/01/2022 - "Further validation of the identified drug targets can help the development of new therapeutics against adenovirus infections."
01/01/2019 - "As there is a need for anti-adenoviral therapies, researchers have been developing new agents and repurposing existing ones to treat adenovirus infections. "

01/01/1985 - "These studies demonstrate that enteric adenovirus infections are major causes of morbidity in hospitalized patients who have of morbidity in hospitalized patients who have undergone ileostomy or colostomy procedures for necrotizing enterocolitis and that the prevention of enteric adenovirus infections might result in a significant improvement in the hospital care of infants with these conditions."
01/01/1985 - "We studied the incidence of enteric adenovirus infections in infants with necrotizing enterocolitis who had undergone intestinal surgery resulting in colostomies or ileostomies. "

01/01/1985 - "These studies demonstrate that enteric adenovirus infections are major causes of morbidity in hospitalized patients who have of morbidity in hospitalized patients who have undergone ileostomy or colostomy procedures for necrotizing enterocolitis and that the prevention of enteric adenovirus infections might result in a significant improvement in the hospital care of infants with these conditions."
01/01/1985 - "We studied the incidence of enteric adenovirus infections in infants with necrotizing enterocolitis who had undergone intestinal surgery resulting in colostomies or ileostomies. "

12/01/2020 - "Antigenic competition in the generation of multi-virus-specific cell lines for immunotherapy of human cytomegalovirus, polyomavirus BK, Epstein-Barr virus and adenovirus infection in haematopoietic stem cell transplant recipients."
01/01/2014 - "Thus, our strategy offers a new means for the immunotherapy of adenovirus infection after allogeneic HSCT. "
01/01/2012 - "Enhanced surveillance with adenovirus PCR and identification of the risk factors associated with poor outcomes from adenovirus infection may identify patients that may benefit from pre-emptive therapeutic interventions including adenovirus-specific cellular immunotherapies."
12/01/2005 - "Thus, we have characterized human T-cell responses to adenovirus in vitro and explored the potential of adoptive T-cell immunotherapy as a prophylactic or therapeutic strategy for adenovirus infections posttransplant."
01/01/2019 - "Notch ligand-expressing adenovirus infection enhances the efficacy of dendritic cell-based immunotherapy for allergic asthma in mice."