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Calcium-Transporting ATPases (Ca2+ ATPase)

Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.
Also Known As:
Ca2+ ATPase; Calcium-ATPase; Adenosine Triphosphatase, Calcium; ATPase, Ca2+; ATPases, Calcium-Transporting; Calcium Adenosine Triphosphatase; Calcium Transporting ATPases; Triphosphatase, Calcium Adenosine; ATPase, Calcium; Adenosinetriphosphatase, Calcium; Ca(2+)-Transporting ATPase; Calcium ATPase; Calcium Adenosinetriphosphatase; ATP phosphohydrolase (Ca(2+)-transporting)
Networked: 341 relevant articles (9 outcomes, 33 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Hajjar, Roger J: 11 articles (01/2020 - 09/2004)
2. Padányi, Rita: 4 articles (03/2021 - 02/2014)
3. Varga, Karolina: 4 articles (03/2021 - 02/2014)
4. Qaisar, Rizwan: 3 articles (01/2022 - 12/2020)
5. Enyedi, Agnes: 3 articles (03/2021 - 02/2014)
6. Pászty, Katalin: 3 articles (01/2017 - 02/2014)
7. Chemaly, Elie R: 3 articles (11/2014 - 05/2006)
8. Marín, Reinaldo: 3 articles (03/2010 - 01/2002)
9. Proverbio, Fulgencio: 3 articles (03/2010 - 01/2002)
10. Hovnanian, Alain: 3 articles (10/2006 - 09/2003)

Related Diseases

1. Heart Failure
2. Heart Diseases (Heart Disease)
08/01/2014 - "On the basis of a gene transfer strategy, we analyzed the therapeutic efficacy of primary gene correction in a δ-sarcoglycan (δ-SG)-deficient animal model versus gene transfer of the Ca(2+) pump hSERCA2a (human sarco-endoplasmic reticulum calcium ATPase 2a), at a symptomatic stage of heart disease. "
08/01/2016 - "Gene therapy by sarcoplasmic reticulum Ca2+ ATPase 2 (SERCA-2a) transfer has been investigated but data from the Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2) trial were disappointing. "
01/01/2023 - "The fast and elevated Ca2+ transient is associated with decreased sarcoplasmic reticulum (SR) Ca2+ ATPase (SERCA2) and increased expression of cardiac ryanodine receptor 2 (RyR2) conducting a potent Ca2+ release from SR.; (4) Conclusions: Our studies validated the association of polymorphic ApoEs with cardiac health in the rat model, and revealed the possible mechanisms of the protective effect of ApoE2 against heart diseases."
04/01/2012 - "Use of gene therapy for heart failure is gaining momentum as a result of the recent successful completion of phase II of the Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) trial, which showed clinical safety and efficacy of an adeno-associated viral vector expressing sarco-endoplasmic reticulum calcium ATPase (SERCA2a). "
09/01/1978 - "The degree of cardiac hypertrophy correlates with the increase total DNA within the heart, and with the lowering of myofibrillary Ca2+ ATPase, the concentration in the collagen remaining unchanged providing there is no ischaemic heart disease. "
3. Fibrosis (Cirrhosis)
4. Dyslipidemias (Dyslipidemia)
5. Hypophosphatemia

Related Drugs and Biologics

1. Calcium
2. Adenosine Triphosphatases (ATPase)
3. Proteins (Proteins, Gene)
4. Enzymes
5. Potassium
6. phospholamban
7. Protein Isoforms (Isoforms)
8. Adenosine Triphosphate (ATP)
9. Protein Kinase C
10. Sarcoglycans (beta Sarcoglycan)

Related Therapies and Procedures

1. Cutaneous Administration
2. Intravenous Infusions
3. Renal Dialysis (Hemodialysis)
4. Aftercare (After-Treatment)
5. Therapeutics