Adenosine Monophosphate (AMP)

Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position.

Also Known As:

AMP; 2'-AMP; 2'-Adenosine Monophosphate; 2'-Adenylic Acid; 5'-Adenylic Acid; Adenosine 2'-Phosphate; Adenosine 3'-Phosphate; Adenosine 5'-Phosphate; Adenosine Phosphate Dipotassium; Adenosine Phosphate Disodium; Phosphaden; 2' Adenosine Monophosphate; 2' Adenylic Acid; 5' Adenylic Acid; 5'-Phosphate, Adenosine; Acid, 2'-Adenylic; Acid, 5'-Adenylic; Adenosine 2' Phosphate; Adenosine 3' Phosphate; Adenosine 5' Phosphate; Dipotassium, Adenosine Phosphate; Disodium, Adenosine Phosphate; Monophosphate, 2'-Adenosine; Phosphate Dipotassium, Adenosine; Phosphate Disodium, Adenosine; Adenylic Acid

Networked: 5507 relevant articles (225 outcomes, 665 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Harder, Jürgen: 14 articles (10/2021 - 02/2006)
2.	Viollet, Benoit: 12 articles (01/2021 - 09/2004)
3.	Hardie, D Grahame: 12 articles (01/2019 - 10/2002)
4.	Prieto, Luis: 12 articles (02/2015 - 06/2002)
5.	Li, Yan: 11 articles (11/2022 - 01/2014)
6.	Yang, Yang: 11 articles (02/2021 - 10/2012)
7.	Postma, D S: 11 articles (03/2011 - 05/2000)
8.	Lipworth, Brian J: 11 articles (01/2011 - 02/2003)
9.	Gläser, Regine: 10 articles (07/2021 - 06/2007)
10.	Lipworth, B J: 10 articles (01/2009 - 10/2000)

Related Diseases

1.	Infections 01/01/2017 - "In summary, these findings are helpful for short AMP design with a highly therapeutic index to treat bacteria-induced infection." 01/01/2020 - "An important consideration is the efficacy of AMP in biological matrices replicating sites of infection, e.g., blood/plasma/serum, lung bronchiolar lavage fluid/sputum, urine, biofilms, etc., as this will likely be more predictive of clinical efficacy. " 08/01/2013 - "Disease severity was significantly improved 7 days after infection, at which time AMP expression was returning to baseline. " 01/01/2020 - "Additionally, specific AST for different target microorganisms may help to better predict efficacy of AMP in specific infections. " 12/01/2013 - "A single-dose AMP regimen was shown to be effective and feasible for prevention of perioperative infection in urological surgery."
2.	Asthma (Bronchial Asthma) 08/02/2010 - "Can AMP induce sputum eosinophils, even in subjects with complete asthma remission?" 09/01/2000 - "The responsiveness to both AMP and MCh of subjects in clinical remission was significantly higher as compared with responsiveness of healthy controls, and lower than responsiveness of subjects with current asthma. " 03/17/1997 - "More research is required on why AMPs are not more generally used and, more importantly, on what elements within the AMP model are useful and effective for people with asthma and likely to be used by their general practitioners (GPs)." 01/01/2002 - "There is inconclusive evidence on the efficacy of outpatient clinic-based asthma management programs (AMP) in children. " 05/01/2000 - "Treatment with low doses of MF DPI decreased airway responsiveness to AMP challenge and improved secondary measures of pulmonary function and asthma symptoms."
3.	Neoplasms (Cancer) 06/01/2022 - "Considering that the loading method for most AMPs is identical to that of KLA, the polymeric carrier reported in this study may provide a feasible approach for the development of AMP-based cancer treatments." 01/01/2022 - "Mechanistic study revealed that GJB3 form channels between PDAC tumor cells and accumulated neutrophil, which transfer cyclic adenosine monophosphate (cAMP) from cancer to neutrophil cells, which supports the survival and polarization. " 04/03/2021 - "In this study, we focused on the anti-tumor activity and mechanism of Brevinin-1RL1, a cationic α-helical AMP isolated from frog Rana limnocharis skin secretions. " 01/01/2019 - "Of the 953 samples from Chinese cancer patients assessed in this study, 35% exhibited high TMB (TMB-H), 4% were positive for high MSI (MSI-H), dMMR occurred in 0.53%, and PD-L1 AMP was positive in 3.79%. " 01/01/2017 - "In a 3-year period, a total of 83 consecutive patients coming to our attention at the Ear-Nose-Throat (ENT) Outpatients Service of the National Cancer Research Center &quot;Istituto Tumori Giovanni Paolo II&quot; of Bari, Italy, because of the finding of one or more cervical lymph node(s), were enrolled in the study. "
4.	Inflammation (Inflammations) 10/01/2001 - "Improvement in PC20 AMP was solely related to reduction in airway inflammation (i.e., change in the number of sputum eosinophils, lymphocytes, epithelial cells, and concentration of NO in exhaled air). " 01/01/2022 - "The study findings indicated that AMP accelerated microglia activation and stimulated inflammation and oxidative stress in brain tissue of rats. " 11/01/2023 - "To further elucidate the biological mechanisms of action, the targeted metabolomics unveiled several inflammation-related metabolites regulating the cell response to the AMP exposure. " 05/01/2023 - "These results suggest that AMP-related genes are closely involved in alterations of OA synovial inflammation. " 01/01/2022 - "These findings provide evidence that Amp plays a protective role in AKI via attenuation of oxidative stress and inflammation mediated by PI3K/AKT/Nrf2 and PI3K/AKT/NF-κB pathways. "
5.	Insulin Resistance 12/01/2020 - "High level of insulin resistance could aggravate the adverse metabolic impact of exposure to UFP and AMP." 11/14/2018 - "These results indicate that ingestion of ADN or AMP induces activation of AMPK in skeletal muscle and mitigates insulin resistance in mice with high-fat diet-induced diabetes." 07/01/2005 - "However, activation of adenosine monophosphate-activated protein kinase, although beneficial in terms of insulin sensitivity, might be detrimental because it can stimulate food intake. " 01/01/2017 - "Despite a fivefold difference in running volume between rat lines, EX similarly improved systemic insulin sensitivity, resting energy expenditure, and skeletal muscle mitochondrial content and adenosine monophosphate-activated protein kinase activation in ovariectomized LCR and HCR rats fed HFD compared with their respective SED controls." 09/24/2008 - "Chronic treatment with the AMP analogue 5-aminoimidazole-4-carboxamide-1-beta-d-ribonucleoside (AICAR) has been shown to improve insulin sensitivity and prevent the development of diabetes in rodents. "

Related Drugs and Biologics

1.	Protein Kinases (Protein Kinase)
2.	Adenosine Triphosphate (ATP)
3.	Methacholine Chloride (Methacholine)
4.	Adenosine Diphosphate (ADP)
5.	Phosphotransferases (Kinase)
6.	Adenosine Monophosphate (AMP)
7.	Proteins (Proteins, Gene)
8.	Amphotericin B (Amphotericin)
9.	Glucose (Dextrose)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Transplantation
4.	Radiotherapy
5.	Oral Administration