Acidophil Adenoma

A benign tumor, usually found in the anterior lobe of the pituitary gland, whose cells stain with acid dyes. Such pituitary tumors may give rise to excessive secretion of growth hormone, resulting in gigantism or acromegaly. A specific type of acidophil adenoma may give rise to nonpuerperal galactorrhea. (Dorland, 27th ed)

Also Known As:

Adenoma, Acidophil; Adenoma, Acidophilic; Adenoma, Eosinophil; Acidophil Adenomas; Acidophilic Adenoma; Acidophilic Adenomas; Adenomas, Acidophil; Adenomas, Acidophilic; Adenomas, Eosinophil; Adenomas, Eosinophilic; Eosinophil Adenoma; Eosinophil Adenomas; Eosinophilic Adenoma; Eosinophilic Adenomas; Adenoma, Eosinophilic

Networked: 29 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Neoplasms: 1324753
- Neoplasms by Histologic Type: 2

Related Diseases

1.	Neoplasms (Cancer)
2.	Adenoma (Adenomas)
3.	Acromegaly
4.	Carcinoma (Carcinomatosis)
5.	Diabetes Mellitus

Experts

1.	Hosaka, Takuomi: 1 article (01/2021)
2.	Ishimura, Mai: 1 article (01/2021)
3.	Kakizaki, Satoru: 1 article (01/2021)
4.	Nobusawa, Sumihito: 1 article (01/2021)
5.	Sasaki, Takamitsu: 1 article (01/2021)
6.	Shizu, Ryota: 1 article (01/2021)
7.	Yoshinari, Kouichi: 1 article (01/2021)
8.	Craddock, Durrett C: 1 article (06/2015)
9.	Nowacki, Michael R: 1 article (06/2015)
10.	Silverman, Craig: 1 article (06/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acidophil Adenoma:

1.	Growth Hormone (Somatotropin)IBA 03/01/1989 - "Immunocytochemical demonstration of growth hormone in an acidophilic adenoma of the adenohypophysis in a cat." 07/01/1979 - "Typical growth hormone (GH) secreting eosinophil adenomas contain large 375 nm granules which dominate the cell cytoplasm. " 01/01/2000 - "The biopsy material consisted of two types of closely adjacent and intermingled tissues, one of which was growth hormone positive acidophilic adenoma, the second component were haphazardly oriented ganglion cells of various size and shape, also multinuclear, with bundles of unmyelinated fibers. " 07/01/1996 - "Diabetes mellitus in a dog with a growth hormone-producing acidophilic adenoma of the adenohypophysis." 03/15/1982 - "Six weeks following the removal of the acidophilic adenoma of the hypophysis administration of insulin could have been ceased, and the results of her growth hormone became normal. "
2.	ProlactinIBA 04/01/1994 - "Prolactin-secreting acidophil adenomas have not been previously reported in the rabbit, and the association with mammary dysplasia is unique." 06/01/1979 - "A mixed chromophobe and acidophilic adenoma was found and both growth hormone and prolactin were demonstrable in different cells of the tumour by the immunoperoxidase technique. " 10/01/1980 - "Exocytosis was characteristic of prolactin cell adenomas, mixed growth hormone-prolactin cell adenomas, acidophil stem cell adenomas, and nontumorous prolactin cells. " 01/01/1983 - "Pituitary causes of acromegaly include densely granulated adenomas, sparsely granulated adenomas, mixed growth hormone and prolactin cell adenomas, acidophil stem cell adenomas, mammosomatotroph cell adenomas, and pleurihormonal adenomas. " 02/01/1986 - "These tumors are associated with elevated blood growth hormone levels and acromegaly or gigantism and can be classified into the following morphologically distinct entities by the combined application of histology, immunocytology, and electron microscopy: densely granulated growth hormone cell adenoma; sparsely granulated growth hormone cell adenoma; mixed growth hormone cell- prolactin cell-adenoma; acidophil stem cell adenoma; mammosomatotroph cell adenoma; growth hormone cell carcinoma; plurihormonal adenoma with growth hormone production."
3.	Adrenocorticotropic Hormone (ACTH)FDA Link 06/01/2015 - "The tumor demonstrated features of an eosinophilic adenoma and stained uniformly for ACTH. " 03/01/1982 - "In the second patients, the selective removal of a small intrasellar eosinophilic adenoma consisting of ACTH-producing cells did not alleviate the hyperpigmentation and did not lower the plasma ACTH concentration. " 01/01/2007 - "The pituitary gland contained an acidophilic adenoma that immunostained positively for GH (and negatively for ACTH and alpha-MSH). " 10/01/2006 - "The tumor resected by transsphenoidal surgery was histopathologically consistent with the diagnosis of eosinophilic adenoma: positive immunoreactivities of GH, PRL and ACTH were demonstrated, but negative immunoreactivities of prohormone convertase (PC) 1/3 by immunohistochemical method. "
4.	Hormones (Hormone)IBA 01/01/1984 - "Eosinophilic adenomas show higher blood hormone levels than mixed and chromophobe tumors. " 01/01/1996 - "FSH/LH cell adenomas, alpha-subunit-only adenomas), bihormonal (mixed GH/Prolactin cell adenomas, mammosomatotroph cell adenomas, acidophil stem cell adenomas), plurihormonal (GH/Prolactin/Glycoprotein-positive adenomas, other Glycoprotein-positive types) and hormone-negative adenomas (null cell adenomas, oncocytic adenomas) have to be differentiated."
5.	Bromocriptine (Parlodel)FDA LinkGeneric 08/16/1979 - "Bromocriptine fails to stop growth of eosinophilic adenomas in acromegaly." 11/01/1987 - "A 21-year-old woman suffering from acromegaly was treated with transsphenoidal subtotal hypophysectomy (microscopy: acidophilic adenoma), followed by x-ray and bromocriptine therapy. "
6.	Proprotein Convertases (Pro-Opiomelanocortin Converting Enzyme)IBA 10/01/2006 - "The tumor resected by transsphenoidal surgery was histopathologically consistent with the diagnosis of eosinophilic adenoma: positive immunoreactivities of GH, PRL and ACTH were demonstrated, but negative immunoreactivities of prohormone convertase (PC) 1/3 by immunohistochemical method. "
7.	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 06/01/1975 - "A unique example of a clinically unsuspected large parasellar meningioma is described in a 36-yr-old pituitary giant who had been treated initially with conventional irradiation, subsequently by surgical excision of an acidophil adenoma, and ultimately with medroxyprogesterone acetate (MPA) prior to his demise. "
8.	Thorium Dioxide (Thorotrast)IBA 01/01/1960 - "[Hypernephroid carcinoma after thorotrast use and eosinophilic adenoma of the hypophysis]."
9.	SaltsIBA 05/01/1970 - "[The state of water-salt metabolism in patients with eosinophilic adenomas of the hypophysis]."
10.	RNA Precursors (Precursor, mRNA)IBA 04/01/2008 - "The expressions of both motilin and its precursor mRNA in thyroid medullary carcinoma and acidophilic adenoma are significantly increased. " 04/01/2008 - "Moreover, the expression of motilin and its precursor mRNA in thyroid medullar carcinoma and acidophilic adenoma were significantly higher than those of normal thyroid tissue (P < 0.05). "

Therapies and Procedures

1.	Hypophysectomy 07/01/1966 - "[2 Normal pregnancies after hypophysectomy for eosinophilic adenoma of the hypophysis]." 11/01/1987 - "A 21-year-old woman suffering from acromegaly was treated with transsphenoidal subtotal hypophysectomy (microscopy: acidophilic adenoma), followed by x-ray and bromocriptine therapy. "
2.	Therapeutics 11/01/1987 - "A 21-year-old woman suffering from acromegaly was treated with transsphenoidal subtotal hypophysectomy (microscopy: acidophilic adenoma), followed by x-ray and bromocriptine therapy. "