|2.||Neoplasm Metastasis (Metastasis)
|4.||Squamous Cell Carcinoma (Epidermoid Carcinoma)
|5.||Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
|1.||Hruban, Ralph H: 76 articles (01/2016 - 01/2002)|
|2.||Yeo, Charles J: 74 articles (09/2015 - 01/2002)|
|3.||Abbruzzese, James L: 64 articles (09/2015 - 01/2002)|
|4.||Beer, David G: 57 articles (09/2015 - 04/2002)|
|5.||Maitra, Anirban: 54 articles (10/2015 - 07/2002)|
|6.||Ajani, Jaffer A: 53 articles (10/2015 - 02/2002)|
|7.||Epstein, Jonathan I: 52 articles (12/2015 - 09/2002)|
|8.||Cameron, John L: 50 articles (09/2014 - 01/2002)|
|9.||Friess, Helmut: 47 articles (07/2015 - 04/2002)|
|10.||Li, Yan: 47 articles (06/2015 - 12/2002)|
|1.||Fluorouracil (Carac)FDA LinkGeneric
07/01/2006 - "There is a threshold 5-FU dose after which the efficacy is dramatically improved-in mice bearing Colon 26 adenocarcinoma, that threshold is a dose of >150 mg/kg/week, and the increased efficacy correlates with about a fourfold increase in the AUC of 5-FU. "
07/01/2010 - "Hence, DPD inhibitory fluorouracil, such as S-1, may have potent therapeutic efficacy for poorly-differentiated adenocarcinoma of the colorectum."
07/01/2004 - "Sustained complete remission of metastatic oesophageal adenocarcinoma using long-term therapy with 5-fluorouracil."
12/01/2007 - "Adjuvant, 5-fluorouracil (5-FU)-based chemoradiotherapy for completely resected high-risk gastric adenocarcinoma has been shown to improve survival in a randomized Intergroup trial. "
11/01/2015 - "In high risk gastric and gastroesophageal adenocarcinoma, adjuvant radiochemotherapy with 5-fluorouracil bolus became a standard adjuvant treatment, showing significant improvement in overall survival after surgery, although with substantial toxicity. "
06/01/2013 - "Gemcitabine (GEM) is a cytotoxic agent that is potent against pancreatic adenocarcinoma. "
01/01/2006 - "Clinically relevant improvement in QOL from baseline was observed more often after PEFG than after gemcitabine, suggesting that the PEFG regimen did not impair QOL, Partial response was associated with improved QOL suggesting that effective treatment of pancreatic adenocarcinoma may have an important role in these patients."
01/01/2015 - "First-line treatment with FOLFIRINOX significantly increases overall survival (OS) in patients with metastatic pancreatic adenocarcinoma (PA) compared with gemcitabine. "
02/25/2013 - "In addition, the cytotoxicity of gemcitabine-loaded particles prepared by Flow Focusing was tested in MCF-7 human breast adenocarcinoma cells, showing significantly greater antitumor activity compared to the free drug and to the gemcitabine-loaded particles synthesized by double emulsion/solvent evaporation. "
04/01/2015 - "Our findings suggest that gemcitabine-based pre-operative chemoradiotherapy may be a safe and effective treatment for pancreatic ductal adenocarcinoma in patients with renal impairment."
|3.||Cisplatin (Platino)FDA LinkGeneric
04/01/2004 - "Primary radiation with weekly cisplatin may be the best option for patients with stage IB(2) to IIA cervical adenocarcinoma. "
08/01/2011 - "Complete remission, in BRCA2 mutation carrier with metastatic pancreatic adenocarcinoma, treated with cisplatin based therapy."
09/01/1982 - "The survival of asynchronous rat ovarian adenocarcinoma cells (ROT68/C1) treated for 1 hr with more than 0.5 microgram/ml of cis-diamminedichloroplatinum (II) (Cisplatin) revealed a marked decrease in a dose-dependent manner, as estimated by the vitro colonyforming method. "
01/01/2014 - "The current study demonstrated an association between ERCC1 expression and sensitivity to cisplatin in cervical adenocarcinoma cells. "
11/01/2013 - "A multicentre, randomised phase 3 trial was undertaken to compare S-1/cisplatin (CS) with infusional 5-FU/cisplatin (CF) in 1053 patients with untreated, advanced gastric/gastroesophageal adenocarcinoma. "
|4.||gefitinib (Iressa)FDA Link
07/01/2009 - "We expected positive results from gefitinib, because the patient fitted the optimal profile: female, never smoker, adenocarcinoma histology. "
01/01/2010 - "A female Asian nonsmoker with adenocarcinoma was given gefitinib as first-line treatment with significant efficacy. "
01/01/2009 - "Gefitinib treatment was of significantly greater benefit in patients with adenocarcinoma than in those with non-adenocarcinoma (test for interaction p< 0.001). "
12/01/2008 - "Gefitinib is a molecular targeting agent and more effective in patients with characteristics of oriental ethnicity, female gender, adenocarcinoma and non-smokers. "
05/01/2011 - "Gefitinib is less effective in non-adenocarcinoma NSCLC harboring EGFR mutations than adenocarcinoma harboring EGFR mutations."
|5.||Paclitaxel (Taxol)FDA LinkGeneric
03/01/2001 - "Weekly paclitaxel was very well tolerated, yet was effective for recurrent cervical adenocarcinoma."
07/01/2007 - "Paclitaxel also has a high response rate for undifferentiated-type adenocarcinoma, and can be expected to show high efficacy for peritoneal dissemination. "
03/01/2001 - "Remission of metastatic cervical adenocarcinoma with weekly paclitaxel."
08/01/1996 - "To evaluate the efficacy of paclitaxel administered to patients with unresectable adenocarcinomas of the gallbladder and biliary tree over 3 hours every 21 days. "
12/01/2015 - "In the present study, the expression of SOX2 was examined by immunohistochemistry (IHC) and real-time PCR in 40 clinical samples and in SKOV3 cells and SKOV3/TAX cells (paclitaxel-resistant human ovarian adenocarcinoma cell line). "
|6.||oxaliplatin (Eloxatin)FDA LinkGeneric
08/01/2015 - "Fluoropyrimidines and oxaliplatin have demonstrated some efficacy against pancreatic adenocarcinoma, but survival remains brief. "
06/01/2011 - "Prospective, randomized trial comparing 5-FU/LV with or without oxaliplatin as adjuvant treatment following curative resection of gastric adenocarcinoma."
01/01/2011 - "In this study, we tested the hypothesis that YB-1 also confers oxaliplatin resistance in colorectal adenocarcinomas. "
08/01/2015 - "None of the tested extracts interfered with the toxicity elicited by oxaliplatin in the human colon adenocarcinoma cell line HT-29. "
04/01/2014 - "S-1 was orally administered for 14 days at a dose of 80-120 mg/body/day to 7 patients with recurrent adenocarcinoma of the uterine cervix, with oxaliplatin being administered intravenously at a dose of 100 mg/m(2) on day 1. Each therapy cycle was 21 days, and the patients received 6 cycles at most. "
|7.||docetaxel (Taxotere)FDA Link
01/01/2015 - "In this study, which led to the approval of nintedanib, addition of nintedanib to docetaxel significantly improved overall survival in patients with adenocarcinoma histology. "
06/01/2015 - "Notably, the subgroup of patients with adenocarcinoma histology experienced a significant improvement in both PFS and OS with nintedanib plus docetaxel, with a greater benefit seen in patients with rapidly progressing disease. "
02/01/2014 - "After a median follow-up of 31·7 months (IQR 27·8-36·1), overall survival was significantly improved for patients with adenocarcinoma histology who progressed within 9 months after start of first-line treatment in the docetaxel plus nintedanib group (206 patients) compared with those in the docetaxel plus placebo group (199 patients; median 10·9 months [95% CI 8·5-12·6] vs 7·9 months [6·7-9·1]; HR 0·75 [95% CI 0·60-0·92], p=0·0073). "
10/01/2010 - "To assess the safety and efficacy of a new neoadjuvant chemoradiation (CRT) docetaxel-based regimen in patients with resectable adenocarcinoma of the pancreatic head or body. "
09/15/1991 - "Taxotere cured early stage pancreatic ductal adenocarcinoma 03 (6 of 6 cures) and colon adenocarcinoma 38 (7 of 7 cures). "
|8.||Leucovorin (Folinic Acid)FDA Link
09/01/1998 - "The objective of this trial was to determine the activity and evaluate the toxicity of UFT plus oral calcium leucovorin in patients with advanced pancreatic adenocarcinoma. "
05/01/2005 - "Standard-dose external radiation and oral UFUR plus leucovorin were used to treat 30 middle and lower rectal adenocarcinoma patients. "
04/01/1992 - "In vivo antitumor effects of fluoropyrimidines on colon adenocarcinoma 38 and enhancement by leucovorin."
06/01/1990 - "Protein-bound folates were also detected in HT29 human colon adenocarcinoma cells grown in 5-formyltetrahydrofolate (maximum, 11 pmol/mg protein). "
05/15/1989 - "Expansion of CH2THF pools in tissues of BALB/c mice bearing s.c.-implanted EMT6 mammary adenocarcinomas was measured after leucovorin administration. "
|9.||Carboplatin (JM8)FDA LinkGeneric
01/01/2003 - "The aim of this study was to investigate the efficacy and toxicity of carboplatin given as monotherapy in endometrial adenocarcinoma. "
10/01/1988 - "A phase II study of carboplatin in adenocarcinoma of the oesophagus."
12/01/1985 - "Phase II trial of carboplatin in patients with adenocarcinomas of the upper gastrointestinal tract."
04/25/2010 - "Combination of carboplatin and Akt inhibitor may provide a therapeutic benefit against ovarian adenocarcinoma."
10/01/2005 - "Colon adenocarcinoma cell line HT-29 was found to be 4-fold less sensitive to MD2 but equally sensitive to MD3 with respect to carboplatin referent compound. "
|10.||Epidermal Growth Factor Receptor (EGF Receptor)IBA
06/01/2005 - "Association between epidermal growth factor receptor mutation and improved survival in never-smokers with primary adenocarcinoma of the lung."
01/01/2016 - "This study aimed to identify differences in microenvironments of lung adenocarcinomas with epidermal growth factor receptor (EGFR) mutations by histological subtypes. "
11/01/2015 - "The purpose of this study was to investigate the radiogenomic correlation between CT gray-level texture features and epidermal growth factor receptor (EGFR) mutation status in adenocarcinoma of the lung. "
04/01/2015 - "In this study, we optimized magnetic- and fluorescence-based isolation protocols to segregate lung epithelial (CD326/epithelial cell adhesion molecule-positive), endothelial (CD31-positive), and immune (CD45-positive) cells, with high purity, from the lungs of transgenic mice with mutant epidermal growth factor receptor-induced lung adenocarcinomas. "
04/01/2014 - "We aimed to study epidermal growth factor receptor (EGFR) expression in surgically resected pancreatic ductal adenocarcinomas (PDACs) by immunohistochemistry and their relationship to clinicopathological features, cell proliferation and cell adhesion protein expression. "
|1.||Drug Therapy (Chemotherapy)
06/01/2014 - "The most interesting approach seems to be early response monitoring during preoperative chemotherapy, which has shown promising results in prospective single center trials (MUNICON I/II) during chemotherapy of adenocarcinoma of the esophagogastric junction (AEG), but needs to be validated in prospective multicenter trails. "
01/01/2014 - "Recent retrospective and prospective studies have helped to clarify the optimal chemotherapy approach for advanced small bowel adenocarcinoma. "
01/01/2014 - "Pathological complete remission of advanced stage rectal adenocarcinoma by chemotherapy alone is rare. "
01/01/2013 - "An unexpected complete remission of advanced intestinal-type vulvar adenocarcinoma after neoadjuvant chemotherapy: a case report and a literature review."
01/01/2012 - "Complete remission from advanced-stage synchronous double primary (SDP) esophageal and gastric adenocarcinoma by chemotherapy alone is rare. "
11/01/2012 - "To evaluate the efficacy of transanal excision (TAE) combined with radiotherapy for rectal adenocarcinoma, assess the ability of pretreatment endoscopic ultrasound (EUS) to predict failures, and determine the prognostic value of downstaging and complete pathological response. "
11/01/2010 - "To examine the efficacy of vaginal vault radiotherapy as adjuvant treatment for patients with high-grade, stage I/II endometrial adenocarcinoma who have been surgically staged. "
07/01/2002 - "Good outcome for patients with adenocarcinoma of the rectum who undergo neoadjuvant external beam radiotherapy and proctectomy is associated with subspecialty training in colon and rectal surgery."
06/01/1999 - "A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy for cervical adenocarcinoma."
11/01/1996 - "We defined the efficacy of radiotherapy for the treatment of high grade (Gleason scores 8 to 10) adenocarcinoma of the prostate. "
|3.||Heterologous Transplantation (Xenotransplantation)
03/27/2008 - "In particular, compound 48 demonstrated significant antitumor efficacy against established HT29 human colon adenocarcinoma xenografts implanted in athymic mice. "
01/01/1992 - "The present data therefore demonstrate the importance of (1) higher doses of [6RS]LV, (2) expansion of pools of CH2-H4PteGlun+H4PteGlun, and (3) dThd salvage capability in potentiation of the therapeutic efficacy of FUra in colon adenocarcinoma xenografts. "
06/01/2015 - "The present pre-clinical study investigated the acute toxicity, systemic exposure, repeat dose toxicity and efficacy of Riminocelles in parallel to Taxol® at an equivalent PTX dose of 10 mg/kg. Daily and weekly dosing schedules were evaluated against Pgp-expressing human colon adenocarcinoma (HCT-15) xenografts implanted subcutaneously in athymic mice. "
07/01/2004 - "To examine the efficacy of this HRE-Egr-TK gene therapy in vivo, the A549 adenocarcinoma xenografts were planted in BALB/c nude mice. "
07/01/1999 - "Efficacy of monoclonal antibody 131I-B72.3 immunoscintigraphy of pancreatic adenocarcinoma xenografts in nude mice."
|4.||Combination Drug Therapy (Combination Chemotherapy)
01/01/2008 - "In the treatment of unresectable, locally advanced or metastatic gastric or gastro-oesophageal junction adenocarcinoma, no chemotherapy combination was accepted as the gold standard. "
01/01/2014 - "Esophagogastric adenocarcinoma mainly occurs in elderly patients, but they are underrepresented in most clinical trials and often do not receive effective combination chemotherapy, most probably for fear of intolerance. "
07/01/2012 - "Information from randomized trials on the role of combination chemotherapy in the adjuvant treatment of pancreatic adenocarcinoma is limited. "
03/26/2011 - "Data from two large, randomized phase III trials support the use of perioperative combination chemotherapy in lower oesophageal and oesophagogastric junction adenocarcinomas, but the contribution of the adjuvant therapy is uncertain. "
12/01/2002 - "Most studies of single-agent or combination chemotherapy in the treatment of patients with advanced adenocarcinoma of the pancreas have documented low response rates and little reproducible impact on patient survival or quality of life. "
10/01/2014 - "Although ERP is a safe procedure, it did not offer a significant improvement in survival, while at the same time leading to an increased incidence of severe diarrhoea for at least 1 year, thus leaving the standard pancreaticoduodenectomy as the surgical method of choice for the treatment of pancreatic head adenocarcinoma."
04/01/2015 - "Because pancreatoduodenectomy for pancreatic adenocarcinoma is focused on disease-free and overall survival, morbidity among long-term survivors is not well described. "
11/01/2009 - "Margin positive pancreaticoduodenectomy is superior to palliative bypass in locally advanced pancreatic ductal adenocarcinoma."
10/01/2014 - "The purpose of the present study was to evaluate the efficacy of extended pancreatoduodenectomy (EPD) and standard pancreatoduodenectomy (SPD) for ductal adenocarcinoma of the head of the pancreas via meta-analysis. "
11/01/2015 - "Has survival following pancreaticoduodenectomy for pancreas adenocarcinoma improved over time?"