Addison Disease (Addison's Disease)

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949 relevant articles (20 outcomes, 39 trials/studies) found for this Disease

Description: An adrenal disease characterized by the progressive destruction of the ADRENAL CORTEX, resulting in insufficient production of ALDOSTERONE and HYDROCORTISONE. Clinical symptoms include ANOREXIA; NAUSEA; WEIGHT LOSS; MUSCLE WEAKNESS; and HYPERPIGMENTATION of the SKIN due to increase in circulating levels of ACTH precursor hormone which stimulates MELANOCYTES.

Also Known As:

Addison's Disease; Addisons Disease; Primary Adrenal Insufficiency; Primary Adrenocortical Insufficiency; Primary Hypoadrenalism; Adrenal Insufficiency, Primary; Adrenocortical Insufficiencies, Primary; Adrenocortical Insufficiency, Primary; Disease, Addison; Hypoadrenalism, Primary; Hypoadrenalisms, Primary; Insufficiencies, Primary Adrenocortical; Insufficiency, Primary Adrenocortical; Primary Adrenocortical Insufficiencies

Relationship Network

Disease Context: Research Results

Endocrine System Diseases: 398

Adrenal Gland Diseases: 7

Adrenal Insufficiency: 1425

Addison Disease: 949

Immune System Diseases: 1319

Autoimmune Diseases: 12462

Addison Disease: 949

Related Diseases

1.	Syndrome
2.	Fatigue
3.	Hypothyroidism
4.	Hyperpigmentation
5.	Thyroid Diseases (Thyroid Disease)

Experts

1.	Badenhoop, Klaus: 4 articles (01/2008 - 06/2002)
2.	Falorni, A: 4 articles (11/2003 - 02/2000)
3.	Husebye, Eystein S: 3 articles (07/2007 - 01/2004)
4.	Usadel, Klaus-H: 3 articles (08/2004 - 06/2002)
5.	Seissler, Jochen: 3 articles (08/2004 - 06/2002)
6.	Laureti, S: 3 articles (11/2003 - 02/2000)
7.	Meyer, Gesine: 2 articles (01/2008 - 08/2004)
8.	Kämpe, Olle: 2 articles (01/2007 - 01/2004)
9.	Bredholt, Geir: 2 articles (05/2006 - 01/2004)
10.	Betterle, C: 2 articles (01/2005 - 05/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Addison Disease:

1.	Adrenocorticotropic Hormone (ACTH)FDA Link 07/01/2000 - "CONCLUSIONS: Our study demonstrates that the low dose ACTH test has a high diagnostic sensitivity and specificity for primary adrenal insufficiency and suggests that it can accurately identify subjects with pre-clinical adrenal dysfunction." 12/01/1975 - "These studies were interpreted as showing both primary adrenal insufficiency and impaired pituitary reserve for ACTH secretion in response to the feedback stimulus. " 06/27/2005 - "Also in these patients, analysis of p-ACTH is of value when suspecting Addison's disease." 06/27/2005 - "The diagnosis of Addison's disease in pregnancy should be based on analysis of p-ACTH which remains within the reference range in normal pregnancy until delivery. " 06/01/2004 - "We measured bone mineral density (BMD) of lumbar spine using dual X-ray absorptiometory in 10 patients with Addison's disease and 5 patients with isolated ACTH deficiency receiving glucocorticoid replacement therapy. " Order ALL the reference details at left...
2.	AutoantibodiesIBA 11/01/2008 - "The aim of the study was evaluation of pituitary autoantibodies in Addison disease patients using immunoblotting methods. " 11/01/2008 - "[The incidence of the pituitary autoantibodies in Addison disease]" 01/01/2008 - "The corresponding serum autoantibodies were detected by Radioimmunoprecipitation assay in 3 of 40 male (7.5%) and 2 of 26 female (7.7%) APS1 patients but in none of either 32 patients with Addison's disease or 116 healthy controls (p = 0.0055). " 05/01/2006 - "CONTEXT: Patients with adrenal cortex autoantibodies (ACA) without overt autoimmune Addison's disease (AAD) are at risk of adrenal failure. " 05/01/2006 - "Estimated risk for developing autoimmune Addison's disease in patients with adrenal cortex autoantibodies." Order ALL the reference details at left...
3.	Dehydroepiandrosterone (DHEA)IBA 02/01/2008 - "CONCLUSION: Although further long-term studies of DHEA therapy, with dosage adjustment, are desirable, our results support some beneficial effects of prolonged DHEA treatment in Addison's disease." 02/01/2008 - "In Addison's disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failure of DHEA synthesis is not typically corrected. " 02/01/2008 - "Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial." 12/01/2005 - "We conclude that DHEA replacement in Addison's disease has significant immunomodulatory properties and propose that it has a greater impact on the human immune system than would be expected from its classification as a dietary supplement." 12/01/2005 - "Dehydroepiandrosterone replacement in patients with Addison's disease has a bimodal effect on regulatory (CD4+CD25hi and CD4+FoxP3+) T cells." Order ALL the reference details at left...
4.	CortisoneIBA 02/25/1961 - "[An improvement in the treatment of Addison's disease: the cortisone-fluorohydrocortisone combination.]" 01/01/1990 - "No evidence of nerve cell loss was found in three cases of Addison's disease that had received cortisone treatment, which is consistent with the experimental observation that even very low levels of cortisone in adrenalectomized rats are sufficient to prevent granule cell loss." 01/01/1981 - "In primary Addison's disease, very high levels (654-1 413 pg/ml) before cortisone therapy and their decline to nearly normal values during therapy are described. " 04/01/1980 - "The patient was on cortisone therapy for Addison's disease prior to the pregnancy. " 11/01/1961 - "Cortisone-DOC therapy of Addison's disease: probable insignificance of dysadrenocorticism." Order ALL the reference details at left...
5.	Hydrocortisone (Cortisol)FDA LinkGeneric 11/01/1993 - "Cortisol also improved basal K excretion (from 10.2 +/- 1.5 to 16.9 +/- 3.5 mmol/5 hr, P < 0.05) and KCl-stimulated K excretion (from 31.6 +/- 2.5 to 45.2 +/- 3.8 mmol/5 hr, P < 0.05) in Addison's disease, although KCl-stimulated K excretion remained below normal (P < 0.01). " 01/01/1993 - "14 adults (8 female, 6 male) with Addison's disease on chronic cortisol replacement participated in the study. " 12/01/2009 - "We studied 8 patients with primary adrenal insufficiency (Addison group) with short-term discontinuation of hydrocortisone substitution and 8 matched healthy controls in 2 randomized conditions. " 06/01/2008 - "Morning serum and salivary cortisol at 8:00 had the same sensitivity to distinguish patients with Addison's disease from healthy controls. " 06/01/2008 - "Morning serum and saliva cortisol in Addison's disease were lower than in controls (6.74+/-1.69 vs 22.58+/-1.78 microg/dL, and 0.15+/-0.25 vs 0.67+/-0.12 microg/dL) (p<0.001). " Order ALL the reference details at left...
6.	AntibodiesIBA 03/01/2007 - "RESULTS: AADC antibodies (Ab) were detected in 12 of 18 (67%) APS I patients and in six of 199 (3%) autoimmune Addison's disease patients. " 07/01/2005 - "Addison's disease is a set of symptoms which is produced due to the destruction of the suprarenal cortex, of a mainly autoimmune origin, on account of the presence of antibodies which attack it. " 12/01/2004 - "Adrenal antibodies have been proposed as a screening tool for Addison's disease in the T1DM population, but doubts remain about their specificity and sensitivity. " 11/01/2003 - "Two (11%) patients with granulomatous Addison's disease had adrenal antibodies. " 11/01/2003 - "Prevalence of adrenal antibodies in Addison's disease among north Indian Caucasians." Order ALL the reference details at left...
7.	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 05/01/2006 - "The steroidogenic enzyme 21-hydroxylase (21OH) is the main autoantigen in autoimmune primary adrenal failure (Addison's disease). " 10/01/2004 - "In the present report, we show the prevalence of different etiologies, clinical manifestations and laboratorial findings, including the adrenal cortex autoantibody, and 21-hydroxylase antibody in a Brazilian series of patients with primary adrenal insufficiency followed at Divisão de Endocrinologia da Universidade Federal de São Paulo (UNIFESP) and at Faculdade de Medicina de Ribeirão Preto-USP (FMRP-USP)." 02/01/2000 - "The main cause of Addison's disease is an autoimmune organ-specific destruction of the cells in the adrenal cortex by an autoreactive process of activated immune cells directed against the steroid-synthesising enzyme 21-hydroxylase. " 01/01/1999 - "Among 21-hydroxylase autoantibody-positive DQ8 patients, 80% with DRB10404 (12 of 15) had Addison's disease, in contrast to 1 of 10 autoantibody-positive patients with DRB10401 or DRB10402 (P < 0.001). " 07/01/1995 - "Steroid 21-hydroxylase gene polymorphism in Addison's disease patients." Order ALL the reference details at left...*
8.	SodiumIBA 02/02/2000 - "Normal sodium levels do not exclude Addison's disease]" 02/01/1972 - "[Sodium in sweat of patients with Addison's disease]" 01/01/1992 - "Therefore, neither a reduction in renal perfusion pressure (renal artery stenosis), nor sodium depletion (Addison's disease) consistently affect peripolar cells in humans. " 01/01/1990 - "The half-life of extra sodium is short in primary aldosteronism and long in Addison's disease: it is also short in some hypertensive subjects but in general lengthens with age. " 01/01/1990 - "Two had Addison's disease, and 15 had unexpectedly high urine sodium concentration without evidence of renal or adrenal insufficiency. " Order ALL the reference details at left...
9.	Insulin (Novolin)FDA Link 06/01/2009 - "CONCLUSIONS: Glucocorticoid replacement therapy in patients with primary adrenal insufficiency and type 1 diabetes leads to significant changes in insulin requirement compared with patients with type 1 diabetes only." 06/01/2009 - "DESIGN AND SUBJECTS: Ten females with primary adrenal insufficiency and type 1 diabetes (mean duration of type 1 diabetes 13+/-11 years and of primary adrenal insufficiency 11+/-9 years) were retrospectively assessed regarding insulin regimen and insulin dose adjustment. " 06/01/2009 - "This may lead to changes in insulin requirement in patients with primary adrenal insufficiency and type 1 diabetes. " 06/01/2009 - "Altered insulin requirement in patients with type 1 diabetes and primary adrenal insufficiency receiving standard glucocorticoid replacement therapy." 06/22/1996 - "Addison's disease presenting as reduced insulin requirement in insulin dependent diabetes." Order ALL the reference details at left...
10.	ReninIBA 11/01/1983 - "Sequential measurements of plasma renin are helpful in analysing states of electrolyte depletion, and in titrating therapy for Addison's disease." 11/01/1996 - "BACKGROUND: Elevation of plasma renin activity (PRA) is a feature of mineralocorticoid deficiency in patients with primary adrenal insufficiency. " 11/01/1996 - "The role of plasma renin activity in evaluating the adequacy of mineralocorticoid replacement in primary adrenal insufficiency." 04/01/1996 - "Atrial natriuretic peptide and plasma renin levels in assessment of mineralocorticoid replacement in Addison's disease." 02/01/1991 - "Plasma renin activity (PRA) and plasma volume (PV) were determined in 22 adult patients treated for Addison's disease (AD) and reporting at the clinic for follow-up. " Order ALL the reference details at left...

Therapies and Procedures

1.	Aftercare (After-Treatment) 07/01/1996 - "Hyper-adrenocorticotropinemia in a patient with Addison's disease after treatment with corticosteroids." 01/01/1995 - "Autoimmune Addison's disease after treatment with interleukin-2 and tumor-infiltrating lymphocytes." 09/01/1975 - "In 1966, we published the case report of a patient with adrenal carcinoma and wide spread metatasis who, after treatment with mitotane (o,p-DDD) and fluorouracil, developed Addison disease accompanied by a clinical remission. " 06/06/1952 - "[Adrenal insufficiency (Addison's disease) after treatment of pemphigus with moranyl and aureomycin; new outbreak of pemphigus during maintenance therapy of Addison's disease with cortisone.]" 01/01/1952 - "[Adrenal insufficiency; Addison's disease during pemphigus after treatment with moranyl and aureomycin; new attack during weak cortisone therapy.]" Order ALL the reference details at left...
2.	Intravenous Injections 10/01/1997 - "After an intravenous injection of 5 microg DDAVP, plasma ACTH levels increased to more than 200% of the basal levels in 10 of 10 patients with Cushing's disease, but remained less than 150% in all of 11 normal subjects, 3 patients with Addison's disease, 5 cases of Cushing's disease in remission, and 3 patients with ectopic ACTH syndrome. " Order ALL the reference details at left...
3.	Combination Drug Therapy (Combination Chemotherapy) 07/01/1993 - "After complete remission with combination chemotherapy, adrenal function recovered normal and pigmentation disappeared, Addison's disease is an extremely rare complication of primary malignant lymphoma of the adrenal gland." Order ALL the reference details at left...
4.	Adrenalectomy 08/01/1998 - "In addition, serum OLS concentrations in patients having undergone bilateral adrenalectomy or diagnosed with Addison's disease (0.62+/-0.19 nmol/l) were similar to concentrations in healthy subjects (0.67+/-0.21 nmol/l). " 12/01/1982 - "In patients with deficient endogenous glucocorticoid production due to primary adrenal insufficiency (n = 4) or bilateral adrenalectomy (n = 2) a rise in LRH-stimulated concentrations of LH was seen following withdrawal of substitution therapy for 84 h. " 01/01/1980 - "[Pregnancy and labor after bilateral adrenalectomy in Addison's disease]" 07/01/1950 - "Congenital adrenal hyperplasia with pseudohermaphrodism and symptoms of Addison's disease; clinical course following bilateral total adrenalectomy, with metabolic studies, pathologic findings and discussion of etiology." 04/01/1997 - "Therefore, we do not recommend routine Cs supplementation in patients undergoing adrenalectomy during tumor nephrectomy, nevertheless, Cs supplementation remains necessary for patients with primary hypothalamic-pituitary-adrenal dysfunction (Addison's disease) or hyperfunction (Cushing's disease)." Order ALL the reference details at left...
5.	Transplantation (Transplant Recipients) 02/01/1990 - "A study of cadaveric fetal adrenal used for adrenal transplantation to treat Addison's disease: thirteen cases reported." 02/01/1964 - "[TRANSPLANTATION OF THE ADRENAL GLAND ON A VASCULAR PEDICLE IN ADDISON'S DISEASE.]" 06/01/1963 - "Fetal adrenal transplantation attempt in juvenile Addison's disease." 10/01/1934 - "TRANSPLANTATION OF THE ADRENAL CORTEX FOR ADDISON'S DISEASE." 01/01/1993 - "In 1951 we achieved the successful transplantation of human embryonic adrenal gland (cortical tissue) in a patient with symptomatic adrenal insufficiency (Addison's disease), apparently the first instance of histologically documented successful homografting of human adrenal cortex. " Order ALL the reference details at left...

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