|2.||Adrenal Insufficiency (Adrenal Gland Hypofunction)
|5.||Thyroid Diseases (Thyroid Disease)
|1.||Husebye, Eystein S: 25 articles (01/2016 - 02/2002)|
|2.||Løvås, Kristian: 16 articles (01/2016 - 02/2002)|
|3.||Falorni, Alberto: 15 articles (10/2015 - 06/2002)|
|4.||Betterle, Corrado: 14 articles (10/2015 - 04/2003)|
|5.||Kämpe, Olle: 11 articles (10/2015 - 06/2002)|
|6.||Eisenbarth, George S: 11 articles (05/2012 - 06/2002)|
|7.||Yu, Liping: 8 articles (10/2015 - 01/2005)|
|8.||Bratland, Eirik: 8 articles (10/2015 - 05/2006)|
|9.||Giordano, Roberta: 8 articles (05/2015 - 03/2005)|
|10.||De Bellis, Annamaria: 8 articles (05/2015 - 08/2002)|
10/01/1996 - "Three patients revealed a polyendocrine syndrome which clinically resembles autoimmune polyendocrine syndrome (APS) type I, but serologically corresponds to APS type II. Polyendocrine disorders are often associated with Addison's disease, and screening, including quantification of autoantibodies, may help to identify those at risk of developing associated autoimmune disorders."
11/01/2008 - "The aim of the study was evaluation of pituitary autoantibodies in Addison disease patients using immunoblotting methods. "
01/01/2014 - "Routine delays in the diagnosis of primary adrenal insufficiency (PAI) are well known and conceivably attributable to the absence of cues, other than anti-adrenal autoantibodies, to pursue subclinical PAI. "
10/01/2012 - "Subclinical Addison's disease is defined by the presence of anti-21-hydroxylase autoantibodies, without clinical symptoms. "
01/01/2010 - "Assays for autoantibodies to the adrenal cortex were strongly positive and confirmed the diagnosis of adrenal failure caused by Addison disease. "
05/21/2012 - "The patient was diagnosed with Addison's disease and responded well to treatment with cortisone. "
02/25/1961 - "[An improvement in the treatment of Addison's disease: the cortisone-fluorohydrocortisone combination]."
01/01/1990 - "No evidence of nerve cell loss was found in three cases of Addison's disease that had received cortisone treatment, which is consistent with the experimental observation that even very low levels of cortisone in adrenalectomized rats are sufficient to prevent granule cell loss."
01/01/1981 - "In primary Addison's disease, very high levels (654-1 413 pg/ml) before cortisone therapy and their decline to nearly normal values during therapy are described. "
04/01/1980 - "The patient was on cortisone therapy for Addison's disease prior to the pregnancy. "
|3.||Adrenocorticotropic Hormone (ACTH)FDA Link
07/01/2000 - "Our study demonstrates that the low dose ACTH test has a high diagnostic sensitivity and specificity for primary adrenal insufficiency and suggests that it can accurately identify subjects with pre-clinical adrenal dysfunction."
09/01/2014 - "We suggest that serum ACTH level testing or tests of mineralocorticoid function be included in the initial step of investigation for suspected primary adrenal insufficiency."
01/01/2013 - "An ACTH stimulation test should confirm the diagnosis when primary adrenal insufficiency is suspected. "
01/01/2011 - "The ACTH stimulation test demonstrated primary adrenal insufficiency, and the other etiologies of primary adrenal insufficiency were excluded. "
06/27/2005 - "Also in these patients, analysis of p-ACTH is of value when suspecting Addison's disease."
|4.||Steroid 21-Hydroxylase (21 Hydroxylase)IBA
12/01/2014 - "Steroid 21-hydroxylase, encoded by CYP21A2, is the major autoantigen in autoimmune Addison's disease (AAD). "
10/01/2014 - "HLA similarities indicate shared genetic risk in 21-hydroxylase autoantibody positive South African and United States Addison's disease."
11/01/2010 - "21-hydroxylase autoantibody (21OHAb) is considered as a valuable marker for identifying patients with autoimmune Addison's disease (AD); however, it is not available in some countries. "
05/01/2006 - "The steroidogenic enzyme 21-hydroxylase (21OH) is the main autoantigen in autoimmune primary adrenal failure (Addison's disease). "
10/01/2004 - "In the present report, we show the prevalence of different etiologies, clinical manifestations and laboratorial findings, including the adrenal cortex autoantibody, and 21-hydroxylase antibody in a Brazilian series of patients with primary adrenal insufficiency followed at Divisão de Endocrinologia da Universidade Federal de São Paulo (UNIFESP) and at Faculdade de Medicina de Ribeirão Preto-USP (FMRP-USP)."
02/01/2008 - "Although further long-term studies of DHEA therapy, with dosage adjustment, are desirable, our results support some beneficial effects of prolonged DHEA treatment in Addison's disease."
01/01/2011 - "Bone mineral density correlated positively with serum DHEA-S, and negatively with the patient's age, duration of the Addison's disease and total steroid dose administered during the therapy. "
02/01/2008 - "In Addison's disease, glucocorticoid and mineralocorticoid deficiencies require lifelong replacement, but the associated near-total failure of DHEA synthesis is not typically corrected. "
02/01/2008 - "Long-term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial."
12/01/2005 - "We conclude that DHEA replacement in Addison's disease has significant immunomodulatory properties and propose that it has a greater impact on the human immune system than would be expected from its classification as a dietary supplement."
|6.||Hydrocortisone (Cortisol)FDA LinkGeneric
11/01/1993 - "Cortisol also improved basal K excretion (from 10.2 +/- 1.5 to 16.9 +/- 3.5 mmol/5 hr, P < 0.05) and KCl-stimulated K excretion (from 31.6 +/- 2.5 to 45.2 +/- 3.8 mmol/5 hr, P < 0.05) in Addison's disease, although KCl-stimulated K excretion remained below normal (P < 0.01). "
01/01/1993 - "14 adults (8 female, 6 male) with Addison's disease on chronic cortisol replacement participated in the study. "
01/01/2016 - "To evaluate cognitive functioning in patients with hypocortisolism (i.e., primary adrenal insufficiency (PAI)) and to examine the possible effect of postponing early-morning hydrocortisone intake on cognitive functioning. "
07/01/2015 - "We report the use of continuous subcutaneous hydrocortisone infusion in an adolescent patient with primary adrenal insufficiency. "
01/01/2015 - "Eventually, the presence of renal angle tenderness on clinical examination and a low random-cortisol level lead to the suspicion of primary adrenal insufficiency. "
03/01/2007 - "AADC antibodies (Ab) were detected in 12 of 18 (67%) APS I patients and in six of 199 (3%) autoimmune Addison's disease patients. "
07/01/2005 - "Addison's disease is a set of symptoms which is produced due to the destruction of the suprarenal cortex, of a mainly autoimmune origin, on account of the presence of antibodies which attack it. "
12/01/2004 - "Adrenal antibodies have been proposed as a screening tool for Addison's disease in the T1DM population, but doubts remain about their specificity and sensitivity. "
11/01/2003 - "Two (11%) patients with granulomatous Addison's disease had adrenal antibodies. "
11/01/2003 - "Prevalence of adrenal antibodies in Addison's disease among north Indian Caucasians."
02/02/2000 - "Normal sodium levels do not exclude Addison's disease]."
02/01/1972 - "[Sodium in sweat of patients with Addison's disease]."
04/30/1933 - "2. It has been shown that the sodium concentration of the blood decreases in adrenalectomized dogs, as is true in patients suffering from Addison's disease and in cats experimentally adrenalectomized. "
01/01/1990 - "The half-life of extra sodium is short in primary aldosteronism and long in Addison's disease: it is also short in some hypertensive subjects but in general lengthens with age. "
01/01/1990 - "Two had Addison's disease, and 15 had unexpectedly high urine sodium concentration without evidence of renal or adrenal insufficiency. "
|9.||Insulin (Novolin)FDA Link
06/01/2009 - "Glucocorticoid replacement therapy in patients with primary adrenal insufficiency and type 1 diabetes leads to significant changes in insulin requirement compared with patients with type 1 diabetes only."
06/01/2009 - "Ten females with primary adrenal insufficiency and type 1 diabetes (mean duration of type 1 diabetes 13+/-11 years and of primary adrenal insufficiency 11+/-9 years) were retrospectively assessed regarding insulin regimen and insulin dose adjustment. "
06/01/2009 - "This may lead to changes in insulin requirement in patients with primary adrenal insufficiency and type 1 diabetes. "
06/01/2009 - "Altered insulin requirement in patients with type 1 diabetes and primary adrenal insufficiency receiving standard glucocorticoid replacement therapy."
01/01/2008 - "Insulin gene polymorphisms in type 1 diabetes, Addison's disease and the polyglandular autoimmune syndrome type II."
11/01/1983 - "Sequential measurements of plasma renin are helpful in analysing states of electrolyte depletion, and in titrating therapy for Addison's disease."
11/01/1996 - "Elevation of plasma renin activity (PRA) is a feature of mineralocorticoid deficiency in patients with primary adrenal insufficiency. "
11/01/1996 - "The role of plasma renin activity in evaluating the adequacy of mineralocorticoid replacement in primary adrenal insufficiency."
04/01/1996 - "Atrial natriuretic peptide and plasma renin levels in assessment of mineralocorticoid replacement in Addison's disease."
02/01/1991 - "Plasma renin activity (PRA) and plasma volume (PV) were determined in 22 adult patients treated for Addison's disease (AD) and reporting at the clinic for follow-up. "
10/01/2012 - "The objective of the study was to determine whether immunomodulatory therapy at an early stage of autoimmune Addison's disease could lead to preservation or improvement in adrenal steroidogenesis. "
06/01/2013 - "Future clinical trials of immunomodulation or immunoprevention will test the possibility to delay (or prevent) the autoimmune destruction of the adrenal gland in autoimmune Addison's disease."
10/01/2012 - "Future studies of immunomodulation in autoimmune Addison's disease may be warranted."
06/01/2014 - "Two studies have also looked at modifying the natural history of adrenal failure using adrenocorticotropic hormone (ACTH) stimulation and immunomodulatory therapies, leading to the concept of residual adrenal function in some Addison's disease patients. "
10/01/1997 - "After an intravenous injection of 5 microg DDAVP, plasma ACTH levels increased to more than 200% of the basal levels in 10 of 10 patients with Cushing's disease, but remained less than 150% in all of 11 normal subjects, 3 patients with Addison's disease, 5 cases of Cushing's disease in remission, and 3 patients with ectopic ACTH syndrome. "
02/13/1971 - "In the group with Addison's disease circulating ACTH values showed a definite nyctohemeral rhythm, a pronounced rise in response to insulin-induced hypoglycaemia, and an immediate fall following the intravenous injection of corticosteroids, with a half-life of between 13.5 and 44.2 minutes. "
|3.||Combination Drug Therapy (Combination Chemotherapy)
09/01/2014 - "Iatrogenic Addison's disease occurring after metastasectomy (adrenalectomy) is an even rarer clinical entity. "
08/01/1998 - "In addition, serum OLS concentrations in patients having undergone bilateral adrenalectomy or diagnosed with Addison's disease (0.62+/-0.19 nmol/l) were similar to concentrations in healthy subjects (0.67+/-0.21 nmol/l). "
12/01/1982 - "In patients with deficient endogenous glucocorticoid production due to primary adrenal insufficiency (n = 4) or bilateral adrenalectomy (n = 2) a rise in LRH-stimulated concentrations of LH was seen following withdrawal of substitution therapy for 84 h. "
01/01/1980 - "[Pregnancy and labor after bilateral adrenalectomy in Addison's disease]."
07/01/1950 - "Congenital adrenal hyperplasia with pseudohermaphrodism and symptoms of Addison's disease; clinical course following bilateral total adrenalectomy, with metabolic studies, pathologic findings and discussion of etiology."
|5.||Transplantation (Transplant Recipients)
02/01/1990 - "A study of cadaveric fetal adrenal used for adrenal transplantation to treat Addison's disease: thirteen cases reported."
02/01/1964 - "[TRANSPLANTATION OF THE ADRENAL GLAND ON A VASCULAR PEDICLE IN ADDISON'S DISEASE]."
06/01/1963 - "Fetal adrenal transplantation attempt in juvenile Addison's disease."
10/01/1934 - "TRANSPLANTATION OF THE ADRENAL CORTEX FOR ADDISON'S DISEASE."
01/01/1993 - "In 1951 we achieved the successful transplantation of human embryonic adrenal gland (cortical tissue) in a patient with symptomatic adrenal insufficiency (Addison's disease), apparently the first instance of histologically documented successful homografting of human adrenal cortex. "