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Acyl Carrier Protein

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Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.

Also Known As:

Myristoyl-ACP; Carrier Protein, Acyl; Myristoyl ACP; Protein, Acyl Carrier

Networked: 23 relevant articles (1 outcomes, 0 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 58375
  - Carrier Proteins: 7715
    - Acyl Carrier Protein: 23

Experts

1.	Surolia, Namita: 3 articles (05/2007 - 01/2004)
2.	Surolia, Avadhesha: 3 articles (05/2007 - 01/2004)
3.	Sharma, Shailendra Kumar: 2 articles (05/2007 - 06/2006)
4.	Bouveret, Emmanuelle: 1 article (01/2009)
5.	Battesti, Aurélia: 1 article (01/2009)
6.	Parasuraman, Prasanna: 1 article (05/2007)
7.	Kumar, Gyanendra: 1 article (05/2007)
8.	Karmodiya, Krishanpal: 1 article (05/2007)
9.	Banerjee, Tanushree: 1 article (05/2007)
10.	Porcelli, Steven A: 1 article (03/2007)

Related Diseases

1.	Tuberculosis 03/20/2007 - "tuberculosis genes encoding distinct beta-ketoacyl- acyl carrier protein synthases involved in mycolic acid synthesis, results in loss of acid-fast staining. " 06/06/2006 - "tuberculosis, expression of one gene from this pathway, lipB, encoding for octanoyl-[acyl carrier protein]-protein acyltransferase is considerably up-regulated, thus making it a potential target in the search for novel antiinfectives against tuberculosis. " 04/04/2006 - "Inhibition of the enzyme Mycobacterium tuberculosis InhA (enoyl-acyl carrier protein reductase) due to formation of an isonicotinoyl-NAD adduct (IN-NAD) from isoniazid (INH) and nicotinamide adenine dinucleotide cofactor is considered central to the mode of action of INH, a first-line treatment for tuberculosis infection. " Order ALL the reference details at left...
2.	Infection 04/04/2006 - "Inhibition of the enzyme Mycobacterium tuberculosis InhA (enoyl-acyl carrier protein reductase) due to formation of an isonicotinoyl-NAD adduct (IN-NAD) from isoniazid (INH) and nicotinamide adenine dinucleotide cofactor is considered central to the mode of action of INH, a first-line treatment for tuberculosis infection. " Order ALL the reference details at left...
3.	Dehydration (Water Stress) 08/12/2005 - "In bacteria, beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase (FabZ) is a potent enzyme in fatty acid biosynthesis and catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP. " 01/01/2004 - "In this cycle, the dehydration of the beta-hydroxyacyl acyl carrier protein is catalyzed by FabZ. " 11/22/2002 - "The double bond is introduced into the growing acyl chain by FabA, an enzyme capable of both the dehydration of beta-hydroxydecanoyl-acyl carrier protein (ACP) to trans-2-decenoyl-ACP, and the isomerization of trans-2 to cis-3-decenoyl-ACP. " 02/01/2007 - "Furthermore, it catalyzed the dehydration of a 3-hydroxyacyl-CoA in coupled reactions with both reductases (MabA and InhA) of the acyl carrier protein (ACP)-dependent M. " 06/01/2005 - "The unique beta-hydroxyacyl-ACP dehydratase in Plasmodium falciparum, PfFabZ, is involved in fatty acid biosynthesis and catalyzes the dehydration of beta-hydroxy fatty acids linked to acyl carrier protein. " Order ALL the reference details at left...
4.	Fatty Liver 11/05/1991 - "We recently reported the expression and characterization of the acyl carrier protein and thioesterase domains of the chicken liver fatty acid synthase in Escherichia coli. " 04/01/1989 - "The acyl carrier protein domain of the chicken liver fatty acid synthase has been isolated after tryptic treatment of the synthase. " 11/10/1974 - "Dissociation of the acyl carrier protein subunit from dog liver fatty acid synthetase complex." 09/09/1974 - "The isolation of acyl carrier protein from the pigeon liver fatty acid synthetase complex1 II." 09/14/1982 - "Isolation and characterization of an acyl carrier protein from pigeon liver fatty acid synthetase by controlled proteolysis with elastase." Order ALL the reference details at left...
5.	Contagious Ecthyma (Orf) 12/13/1996 - "Orf* is a new kind of acyl carrier protein because it is only approximately 25% identical both to the constitutive acyl carrier protein (AcpP) and to the inducible acyl carrier protein (NodF) of R. " 04/01/1994 - "A second, 1,518-bp ORF (hetM) that ends 556 bp 5' from the start of hetN appears to encode a protein that has at least two functional domains: its amino terminus is similar to an acyl carrier protein, while its central portion is similar to domains of proteins that perform reductive reactions. " 03/01/1996 - "The partial ORF encoded a protein with similarity with the 3-oxoacyl-[acyl-carrier-protein] reductases; it was not essential for growth on methanol or ethanol." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Oxidoreductases
2.	NAD (NADH)
3.	Isoniazid (Ftivazide)
4.	Ligases
5.	Staphylococcal Protein A (A, Protein)
6.	Pancreatic Elastase (Elastase)
7.	Citric Acid (Citrate)
8.	Proteins (Proteins, Gene)
9.	Mycolic Acids (Mycolic Acid)
10.	Methionine (L-Methionine)

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