Acyl Carrier Protein

Consists of a polypeptide chain and 4'-phosphopantetheine linked to a serine residue by a phosphodiester bond. Acyl groups are bound as thiol esters to the pantothenyl group. Acyl carrier protein is involved in every step of fatty acid synthesis by the cytoplasmic system.

Also Known As:

Networked: 69 relevant articles (3 outcomes, 5 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Surolia, Avadhesha: 3 articles (05/2007 - 01/2004)
2.	Surolia, Namita: 3 articles (05/2007 - 01/2004)
3.	Aoki, Shunsuke: 2 articles (01/2020 - 04/2015)
4.	Kitamura, Mitsuru: 2 articles (01/2020 - 04/2015)
5.	Leylavergne, François: 2 articles (01/2020 - 01/2019)
6.	Overcash, J Scott: 2 articles (01/2020 - 01/2019)
7.	Sakamoto, Hiroshi: 2 articles (01/2020 - 04/2015)
8.	Taira, Junichi: 2 articles (01/2020 - 04/2015)
9.	Wittke, Frederick: 2 articles (01/2020 - 01/2019)
10.	Ye, Jianping: 2 articles (01/2020 - 09/2017)

Related Diseases

1.	Infections 01/01/2013 - "The Francisella tularensis FabI enoyl-acyl carrier protein reductase gene is essential to bacterial viability and is expressed during infection." 01/22/2015 - "Mycobacterial enoyl acyl carrier protein reductase (InhA) is a clinically validated target for the treatment of tuberculosis infections, a disease that still causes the death of at least a million people annually. " 12/28/2015 - "This open-label noncontrolled, phase II multicenter trial was designed to evaluate the safety, tolerability, and efficacy of 200 mg of AFN-1252, a selective inhibitor of Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI), given by mouth twice daily in the treatment of acute bacterial skin and skin structure infections (ABSSSI) due to staphylococci. " 01/01/2022 - "Mycobacterial acyl carrier protein (AcpM; Rv2244), a key protein involved in Mycobacterium tuberculosis (Mtb) mycolic acid production, has been shown to suppress host cell death during mycobacterial infection. " 04/15/2014 - "The findings of this study not only validated Cryptosporidium ACS (and related acyl-[acyl-carrier-protein]-ligases) as pharmacological targets but also indicate that triacsin C and analogues can be explored as potential new therapeutics against the virtually untreatable cryptosporidial infection in immunocompromised patients."
2.	Tuberculosis (Tuberculoses) 04/24/2022 - "tuberculosis' enoyl-acyl carrier protein reductase InhA which is considered a promising, well-studied target for anti-tuberculosis medication development. " 01/01/2019 - "Development of 1,2,4-Triazole-5-Thione Derivatives as Potential Inhibitors of Enoyl Acyl Carrier Protein Reductase (InhA) in Tuberculosis." 06/06/2006 - "tuberculosis, expression of one gene from this pathway, lipB, encoding for octanoyl-[acyl carrier protein]-protein acyltransferase is considerably up-regulated, thus making it a potential target in the search for novel antiinfectives against tuberculosis. " 01/01/2023 - "2-trans enoyl-acyl carrier protein reductase (InhA) is a promising target for developing novel chemotherapy agents for tuberculosis, and their inhibitory effects on InhA activity were widely investigated by the physicochemical experiments. " 01/01/2019 - "2-trans enoyl-acyl carrier protein reductase (InhA) has been identified as a promising target for the development of novel chemotherapy for tuberculosis. "
3.	Malaria 01/01/2023 - "Identification of natural products against enoyl-acyl-carrier-protein reductase in malaria via combined pharmacophore modeling, molecular docking and simulations studies." 10/06/2021 - "Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites." 06/06/2006 - "Acyl Carrier Protein (ACP) from the malaria parasite, Plasmodium falciparum (PfACP) in its holo form is found to exist in two conformational states in solution. " 11/01/2012 - "Enoyl-acyl carrier protein reductase (ENR) is a crucial enzyme in the type II fatty acid synthesis pathway of many pathogens such as Plasmodium falciparum, the etiological agent of the most severe form of malaria. " 05/31/2007 - "Enoyl acyl carrier protein (ACP) reductase, one of the enzymes of the type II fatty acid biosynthesis pathway, has been established as a promising target for the development of new drugs for malaria. "
4.	African Trypanosomiasis (Nagana) 01/01/2021 - "Here, we present a computational and in vitro workflow for the discovery of new inhibitors of PPI in Escherichia coli FAS-II. As part of this study, we identified suramin, an existing treatment for African sleeping sickness, to effectively block the interaction of E. coli dehydratase FabA and the acyl carrier protein EcACP, with an IC50 = 85 μΜ. "
5.	Dehydration (Water Stress) 01/01/2004 - "In this cycle, the dehydration of the beta-hydroxyacyl acyl carrier protein is catalyzed by FabZ. " 01/01/2021 - "Double bond formation by polyketide synthases (PKSs) is widely recognised to be catalysed by ketoreduction and subsequent dehydration of the acyl carrier protein (ACP)-tethered 3-ketoacyl intermediate in the PKS biosynthetic assembly line with a specific stereochemical course in which the ketoreduction step determines the usual trans or more rare cis double bond configuration. " 03/26/2014 - "Here we demonstrate that this TE catalyzes the dehydration of the polyketide intermediate to yield a cis-double bond and a mutated KS transfers the nascent polyketide chain with only a cis-double bond to the downstream acyl carrier protein. " 02/01/2007 - "Furthermore, it catalyzed the dehydration of a 3-hydroxyacyl-CoA in coupled reactions with both reductases (MabA and InhA) of the acyl carrier protein (ACP)-dependent M. " 11/22/2002 - "The double bond is introduced into the growing acyl chain by FabA, an enzyme capable of both the dehydration of beta-hydroxydecanoyl-acyl carrier protein (ACP) to trans-2-decenoyl-ACP, and the isomerization of trans-2 to cis-3-decenoyl-ACP. "

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	API 1252
3.	Enzymes
4.	Isoniazid (Ftivazide)
5.	NAD (NADH)
6.	CG 400549
7.	2-hydroxypyridine
8.	Prodrugs
9.	Anti-Bacterial Agents (Antibiotics)
10.	afabicin

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)