A protein factor that regulates the length of R-actin. It is chemically similar, but immunochemically distinguishable from actin.
Also Known As:
Eu-Actinin; beta-Actinin; Eu Actinin; alpha Actinin; beta Actinin; alpha-Actinin; Actinins, alpha-
Networked: 240 relevant articles (2 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Putterman, Chaim: 9 articles (07/2015 - 03/2002)
2. Youinou, Pierre: 7 articles (07/2015 - 08/2006)
3. Renaudineau, Yves: 6 articles (07/2015 - 08/2006)
4. Kao, Hung-Ying: 4 articles (01/2015 - 01/2011)
5. Tsuda, Hitoshi: 3 articles (01/2014 - 12/2007)
6. Honda, Kazufumi: 3 articles (01/2014 - 12/2007)
7. Yamada, Tesshi: 3 articles (01/2014 - 12/2007)
8. Zachou, Kalliopi: 3 articles (05/2011 - 11/2006)
9. Schulz, Richard: 3 articles (10/2010 - 10/2007)
10. Fürst, Dieter O: 3 articles (09/2010 - 01/2003)

Related Diseases

1. Wounds and Injuries (Trauma)
2. Cardiomegaly (Heart Hypertrophy)
10/01/2004 - "Calcineurin, which binds to the Z-disc in cardiomyocytes via alpha-actinin, promotes cardiac hypertrophy in response to numerous pathologic stimuli. "
04/01/2006 - "Assessment of the effects of triflusal in pressure overload-induced cardiac hypertrophy by aortic banding resulted in a significant reduction in the ratio of heart weight to body weight and in a reduction of the mRNA levels of the cardiac hypertrophy markers ANF and alpha-actinin compared with untreated banded rats. "
04/19/2002 - "Recently, we described two novel striated muscle-specific proteins, calsarcin-1 and calsarcin-2, that bind alpha-actinin on the Z-disc and serve as intracellular binding proteins for calcineurin, a calcium/calmodulin-dependent phosphatase shown to be integral in cardiac hypertrophy as well as skeletal muscle differentiation and fiber-type specification. "
02/01/1999 - "It was found that: (1) the amount and distribution of alpha-actinin and myomesin remained unchanged at both the compensated hypertrophy and the congestive heart failure stages; (2) loss of titin was associated with myocyte lengthening in heart failure; (3) desmin protein and filaments in LV myocytes increased progressively with mechanical overload cardiac hypertrophy and subsequent heart failure; (4) a newly developed and validated quantitative confocal microscopic approach disclosed that the microtubule density in isolated LV myocytes increased by 21% at 4 weeks and by 48% 6 months after aortic constriction; (5) at the heart failure stage, microtubule density in LV myocytes showed a statistically significant inverse correlation to the LV maximum +dP/dt and a direct correlation to LV myocyte lengthening; (6) the increased microtubule density in LV myocytes in this model was not due to an increase in total tubulin; and (7) microtubule density in left atrial and right ventricular myocytes also increased when they underwent hypertrophy secondary to left heart failure. "
3. Body Weight (Weight, Body)
4. Lupus Nephritis
5. Systemic Lupus Erythematosus (Libman-Sacks Disease)

Related Drugs and Biologics

1. Messenger RNA (mRNA)
2. Atrial Natriuretic Factor (ANF)
3. Gold Colloid (Colloidal Gold)
4. triflusal
5. Antibodies
6. Proteins (Proteins, Gene)
7. Myosins (Myosin)
8. Vinculin
9. Talin
10. Desmin

Related Therapies and Procedures

1. Ligation
2. Cardiac Resynchronization Therapy
3. Surgical Instruments (Clip)