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Acrolein (Aqualin)

Also Known As:
Aqualin; 2-Propenal; Acraldehyde; Acrylaldehyde; Acrylic Aldehyde; Allyl Aldehyde; Ethylene Aldehyde; 2 Propenal; Aldehyde, Acrylic; Aldehyde, Allyl; Aldehyde, Ethylene
Networked: 428 relevant articles (13 outcomes, 59 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Igarashi, Kazuei: 26 articles (10/2015 - 05/2003)
2. Kashiwagi, Keiko: 22 articles (10/2015 - 05/2003)
3. Shi, Riyi: 19 articles (06/2014 - 12/2003)
4. Bhatnagar, Aruni: 16 articles (08/2015 - 08/2003)
5. Yoshida, Madoka: 13 articles (10/2015 - 01/2009)
6. Saiki, Ryotaro: 12 articles (10/2015 - 10/2009)
7. Conklin, Daniel J: 11 articles (08/2015 - 04/2009)
8. Uchida, Koji: 11 articles (11/2012 - 12/2002)
9. Srivastava, Sanjay: 10 articles (08/2015 - 08/2003)
10. Burcham, Philip C: 10 articles (02/2015 - 10/2003)

Related Diseases

1. Neuroblastoma
2. Cystitis
3. Macular Degeneration (Age-Related Maculopathy)
04/01/2011 - "Acrolein, a toxic, reactive aldehyde formed metabolically and environmentally, has been implicated in the damage to and dysfunction of the retinal pigment epithelium (RPE) that accompanies age-related macular degeneration (AMD). "
12/01/2007 - "In the present study, we investigated the protective effects of HTS on acrolein-induced toxicity in human retinal pigment epithelial cell line, ARPE-19, a cellular model of smoking- and age-related macular degeneration. "
11/01/2013 - "Since acrolein challenge of ARPE-19 cells has been used as a model of smoking and age-related macular degeneration (AMD), we concluded that the curcumin analog, C3, may be a more promising drug candidate for its potential application for the prevention and treatment of eye diseases, such as AMD."
11/01/2010 - "Studies in this laboratory have previously shown that hydroxytyrosol, the major antioxidant polyphenol in olives, protects ARPE-19 human retinal pigment epithelial cells from oxidative damage induced by acrolein, an environmental toxin and endogenous end product of lipid oxidation, that occurs at increased levels in age-related macular degeneration lesions. "
01/01/2007 - "To understand better the cell and molecular basis for the epidemiologic association between cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retinal pigment epithelial (RPE) cells and the reduction of this damage by lipoic acid. "
4. Chronic Kidney Failure (Chronic Renal Failure)
5. Carcinoma (Carcinomatosis)

Related Drugs and Biologics

1. Glutathione (Reduced Glutathione)
2. Cyclophosphamide (Cytoxan)
3. Retinaldehyde (Retinal)
4. Interleukin-6 (Interleukin 6)
5. Vitamin E
6. Transferases
7. Aldehyde Reductase (Aldose Reductase)
8. Messenger RNA (mRNA)
9. Cytochrome P-450 Enzyme System (Cytochrome P450)
10. Cysteine (L-Cysteine)

Related Therapies and Procedures

1. Intravesical Administration
2. Renal Dialysis (Hemodialysis)
3. Drug Therapy (Chemotherapy)
4. Catheters
5. Transplants (Transplant)