|1.||Igarashi, Kazuei: 26 articles (10/2015 - 05/2003)|
|2.||Kashiwagi, Keiko: 22 articles (10/2015 - 05/2003)|
|3.||Shi, Riyi: 19 articles (06/2014 - 12/2003)|
|4.||Bhatnagar, Aruni: 16 articles (08/2015 - 08/2003)|
|5.||Yoshida, Madoka: 13 articles (10/2015 - 01/2009)|
|6.||Saiki, Ryotaro: 12 articles (10/2015 - 10/2009)|
|7.||Conklin, Daniel J: 11 articles (08/2015 - 04/2009)|
|8.||Uchida, Koji: 11 articles (11/2012 - 12/2002)|
|9.||Srivastava, Sanjay: 10 articles (08/2015 - 08/2003)|
|10.||Burcham, Philip C: 10 articles (02/2015 - 10/2003)|
12/01/2008 - "The present study investigated the protective effects of PYC on acrolein-induced oxidative cell toxicity in cultured SH-SY5Y neuroblastoma cells. "
01/01/2010 - "In this study, the molecular basis of acrolein-induced cytotoxicity in human neuroblastoma SH-SY5Y cells and the modulating effects of REO were examined. "
01/01/2015 - "igniarius were then used to prevent acrolein toxicity in a mouse neuroblastoma (Neuro-2a) cell line. "
09/01/2013 - "Human neuroblastoma cells SK-N-SH were treated with acrolein. "
01/01/2010 - "Thus, our findings demonstrate that BM can protect human neuroblastoma cells against H2O2 and acrolein through different mechanisms involved in the pathophysiology of AD and could have a therapeutic application in the prevention of AD."
06/01/1993 - "The present study was designed to evaluate the effects of HBO on acute acrolein-induced hemorrhagic cystitis in a rat model. "
01/01/2013 - "Taken together, these results suggest that an IL-6-regulated iNOS/NO signaling pathway participates in the acrolein-triggered detrusor contraction inhibition and hemorrhagic cystitis. "
01/01/2013 - "Both the iNOS inhibitor and IL-6-neutralizing antibody effectively reversed the increased iNOS expression, decreased PKC phosphorylation, increased bladder weight, and hemorrhagic cystitis in rats 24 h after acrolein treatment. "
10/01/2011 - "Acrolein (1 mM, 400 µL) was instilled into bladders of female Wistar rats to induce cystitis. "
04/01/2008 - "Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis."
|3.||Macular Degeneration (Age-Related Maculopathy)
04/01/2011 - "Acrolein, a toxic, reactive aldehyde formed metabolically and environmentally, has been implicated in the damage to and dysfunction of the retinal pigment epithelium (RPE) that accompanies age-related macular degeneration (AMD). "
12/01/2007 - "In the present study, we investigated the protective effects of HTS on acrolein-induced toxicity in human retinal pigment epithelial cell line, ARPE-19, a cellular model of smoking- and age-related macular degeneration. "
11/01/2013 - "Since acrolein challenge of ARPE-19 cells has been used as a model of smoking and age-related macular degeneration (AMD), we concluded that the curcumin analog, C3, may be a more promising drug candidate for its potential application for the prevention and treatment of eye diseases, such as AMD."
11/01/2010 - "Studies in this laboratory have previously shown that hydroxytyrosol, the major antioxidant polyphenol in olives, protects ARPE-19 human retinal pigment epithelial cells from oxidative damage induced by acrolein, an environmental toxin and endogenous end product of lipid oxidation, that occurs at increased levels in age-related macular degeneration lesions. "
01/01/2007 - "To understand better the cell and molecular basis for the epidemiologic association between cigarette smoke, oxidant injury, and age-associated macular degeneration, the authors examined the effects of acrolein, a major toxicant in cigarette smoke, on oxidative mitochondrial damage in retinal pigment epithelial (RPE) cells and the reduction of this damage by lipoic acid. "
|4.||Chronic Kidney Failure (Chronic Renal Failure)
09/01/2007 - "We confirm that free serum acrolein levels are higher in chronic renal failure patients and demonstrate that they are partially removed by HD. "
11/01/2006 - "Acrolein levels were enhanced in plasma of patients with chronic renal failure. "
05/23/2003 - "Our results indicate that the level of acrolein is well correlated with the degree of seriousness of chronic renal failure."
04/01/2003 - "The levels of free and protein-conjugated acrolein were also increased in plasma of patients with chronic renal failure. "
09/01/2007 - "We confirm that acrolein levels are higher in ESRD and show for the first time, data supporting that acrolein is partially removed by hemodialysis. "
01/25/2013 - "Thus, the mechanism of cell toxicity by acrolein was studied using mouse mammary carcinoma FM3A cells. "
05/01/2010 - "Lipid peroxidation product acrolein as a predictive biomarker of prostate carcinoma relapse after radical surgery."
06/01/2006 - "However, in advanced Dukes B and C carcinomas acrolein was hardly noticed, although, its protein adducts were found abundant in non-malignant colon epithelium of these patients. "
05/01/2010 - "Therefore, identifying predictive markers of tumour recurrence is very important, so this study evaluated the presence of lipid peroxidation product acrolein in primary prostate carcinomas, assuming that acrolein could be involved in prostate carcinogenesis as was recently shown for colon cancer. "
02/03/2012 - "The IC(50) of acrolein in mouse mammary carcinoma FM3A cells and in neuroblastoma Neuro2a cells was 2.6 and 4.2μM, respectively, but in acrolein toxicity-decreasing FM3A (FM3A-ATD) cells and Neuro2a (Neuro2a-ATD) cells, it was 7.6 and 8.4μM, respectively. "
|1.||Glutathione (Reduced Glutathione)
|4.||Interleukin-6 (Interleukin 6)
|7.||Aldehyde Reductase (Aldose Reductase)
|8.||Messenger RNA (mRNA)
|9.||Cytochrome P-450 Enzyme System (Cytochrome P450)
|2.||Renal Dialysis (Hemodialysis)
|3.||Drug Therapy (Chemotherapy)