Acriflavine

3,6-Diamino-10-methylacridinium chloride mixt. with 3,6-acridinediamine. Fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication.

Also Known As:

Networked: 114 relevant articles (11 outcomes, 15 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Semenza, Gregg L: 4 articles (01/2017 - 10/2009)
2.	Bulle, Ashenafi: 3 articles (01/2020 - 02/2017)
3.	Dekervel, Jeroen: 3 articles (01/2020 - 02/2017)
4.	Van Cutsem, Eric: 3 articles (01/2020 - 02/2017)
5.	Verslype, Chris: 3 articles (01/2020 - 02/2017)
6.	van Pelt, Jos: 3 articles (01/2020 - 02/2017)
7.	Eftekhar, Ebrahim: 2 articles (04/2022 - 06/2018)
8.	Zargar, Parisa: 2 articles (04/2022 - 06/2018)
9.	Brem, Henry: 2 articles (01/2022 - 11/2017)
10.	Mangraviti, Antonella: 2 articles (01/2022 - 11/2017)

Related Diseases

1.	Rhinoscleroma 07/01/1981 - "Local acriflavine: a new therapy for rhinoscleroma." 04/01/1988 - "Shaer et al. (1981) reported that local application of 2 per cent acriflavine solution over an eight-week period was an effective and safe remedy for rhinoscleroma. " 07/01/1981 - "Local acriflavine solution, in a concentration of 2 per cent, has been shown to be an effective and safe remedy for rhinoscleroma."
2.	Neoplasms (Cancer) 02/01/2017 - "We wanted to study the effect of acriflavine on EMT in different human cancer models. " 07/12/2023 - "The mechanism determining the selective uptake of acriflavine and ACF : DOX complexes towards non-cancer and cancer cells should be better understood in the future, as it may be of key importance in the design of complexes with toxic anti-cancer drugs." 05/02/2023 - "Retraction for Lee et al., Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization." 08/01/2020 - "After acriflavine application, there was a clear difference between cancer and normal mucosa in the uniformity of nuclear size and shape. " 01/01/2020 - "The antibacterial drug acriflavine (ACF) has been shown to have anti-cancer activities in cell lines. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "While various agents have emerged as potential MCL‑1 blockers, the present study presented acriflavine (ACF) as a novel MCL‑1 inhibitor in triple‑negative breast cancer (TNBC). " 01/01/2014 - "HIF-1 Dimerization Inhibitor Acriflavine Enhances Antitumor Activity of Sunitinib in Breast Cancer Model." 07/01/2012 - "We investigated the effect of two chemically and mechanistically distinct HIF inhibitors, digoxin and acriflavine, on breast cancer metastatic niche formation. " 09/01/1985 - "A DNA image cytometry method, implemented on the LEYTAS image processing system, has been applied to acriflavine-Feulgen-stained breast cancer cytology specimens. " 11/15/2018 - "Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer."
4.	Wounds and Injuries (Trauma) 12/01/2009 - "The aim of this study is to investigate clinically the ability of honcrivine (honey plus acriflavine 0.1%) to chemically debride various wounds in routine clinical practice. " 02/04/1928 - "THE FIXATION OF ANTISEPTICS BY DRESSINGS AND TISSUES: ITS IMPORTANCE IN WOUND TREATMENT, WITH SPECIAL REFERENCE TO ACRIFLAVINE." 03/01/1919 - "ACRIFLAVINE EMULSION AS A WOUND DRESSING." 07/07/1917 - "ACRIFLAVINE PASTE AS A DRESSING FOR INFECTED WOUNDS." 07/01/2014 - "Cationic biological dyes such as methylene blue, crystal violet and acriflavine were effective in local wound therapy and today provide a sound basis for light-activated antimicrobial therapeutics. "
5.	Brain Neoplasms (Brain Tumor) 11/02/2017 - "Here we describe the efficacy of a HIF-1α inhibitor, Acriflavine, and demonstrate its potency against brain cancer. " 11/02/2017 - "HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy." 01/01/2018 - "This study describes potential advantages of CSM imaging of fresh human brain tumor tissues labeled with acriflavine (AF), acridine orange (AO), cresyl violet (CV), methylene blue (MB), and indocyanine green (ICG) within the neurosurgical operating room facility. "

Related Drugs and Biologics

1.	Solutions
2.	Methylene Blue (Methylthioninium Chloride)
3.	Periodic Acid
4.	Hematoxylin (Haematoxylon)
5.	Eosine Yellowish-(YS) (Eosin)
6.	Gentian Violet (Violet, Crystal)
7.	Nanocapsules
8.	Lipids
9.	Coloring Agents (Dyes)
10.	Anti-Bacterial Agents (Antibiotics)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Topical Administration
4.	Catheters
5.	Drug Therapy (Chemotherapy)