|1.||Acquired Immunodeficiency Syndrome (AIDS)
|3.||Kaposi Sarcoma (Kaposi's Sarcoma)
|4.||HIV Infections (HIV Infection)
|1.||Jacobson, Lisa P: 57 articles (10/2015 - 08/2002)|
|2.||Hogg, Robert S: 41 articles (04/2015 - 07/2002)|
|3.||Jabs, Douglas A: 36 articles (04/2015 - 01/2002)|
|4.||Detels, Roger: 36 articles (03/2015 - 04/2002)|
|5.||Margolick, Joseph B: 35 articles (10/2015 - 04/2002)|
|6.||Dezube, Bruce J: 34 articles (04/2014 - 01/2002)|
|7.||De Clercq, Erik: 33 articles (06/2015 - 07/2002)|
|8.||Haas, David W: 32 articles (12/2015 - 06/2003)|
|9.||Costagliola, Dominique: 32 articles (12/2015 - 05/2002)|
|10.||Montaner, Julio S G: 32 articles (05/2015 - 08/2002)|
|1.||Zidovudine (Retrovir)FDA LinkGeneric
07/01/1987 - "However, its in vitro chemotherapeutic index is higher than that of 3'-azido-2',3'-dideoxythymidine, a drug which has recently proven effective in the treatment of acquired immunodeficiency syndrome. "
01/01/1997 - " Following the release of the results of the AIDS Clinical Trials Group (ACTG) 076 study, the routine use of zidovudine (AZT) among HIV-infected pregnant women in the US and Europe has resulted in a significant reduction in the rate of mother-to-child vertical HIV transmission. "
05/01/1996 - "Randomized study of the tolerance and efficacy of high- versus low-dose zidovudine in human immunodeficiency virus-infected children with mild to moderate symptoms (AIDS Clinical Trials Group 128). "
01/01/1995 - "Following results showing zidovudine to be significantly more effective than placebo in delaying the progression to AIDS in HIV-infected patients with CD4+ counts < 500 cells/microliters, further analysis of data from this trial showed that immediate zidovudine significantly delayed the time to reach a CD4+ count of 500 cells/microliters in patients with > 500 cells/microliters compared with deferred therapy. "
07/01/1993 - "A significantly greater proportion of individuals who had never received treatment with zidovudine developed AIDS compared with individuals who had (P = 0.04). "
|2.||Ganciclovir (Cytovene)FDA LinkGeneric
01/01/2014 - "We present the case of a 31-year-old man with AIDS and diagnosis of PEL, in whom sustained and complete remission of the tumour was achieved with adjunctive ganciclovir therapy. "
12/01/1989 - "This study supports the conclusions of previous uncontrolled studies that ganciclovir is beneficial in the treatment of patients with acquired immunodeficiency syndrome and cytomegalovirus retinopathy. "
08/01/2000 - "The BIE results for the ganciclovir prophylaxis arm, in contrast, showed a significant reduction of 27% in hospital cost among hospital users, and 44% among the total sample of AIDS patients. "
07/01/1987 - "By reducing or delaying visual loss, ganciclovir appears to be useful in the management of CMV retinopathy in patients with AIDS."
04/01/1987 - "In addition, the prognosis for survival of AIDS patients being treated with ganciclovir is improved when compared with that of untreated patients."
|3.||Fluconazole (Zonal)FDA LinkGeneric
07/01/1994 - "High-dose fluconazole appears safe and effective for cryptococcal disease in AIDS patients."
02/01/1996 - "Improved standardization of fluconazole susceptibility testing has resulted in demonstrable correlations between yeast resistance in vitro and in vivo for this agent in the AIDS setting. "
06/01/1991 - "Safety and efficacy of fluconazole treatment for Candida oesophagitis in AIDS."
09/01/2008 - "This study was designed to investigate the: existence of OPC, species distribution fluconazole susceptibility profile of yeast cells isolated from oral specimens of HIV/AIDS patients from Lagos Nigeria, between Oct. "
10/01/2002 - "This study provides important baseline data as the isolates were collected prior to fluconazole being made freely available to HIV/AIDS patients attending government health clinics."
04/01/2015 - "Recent aids from public and private funding, tiered vaccine pricing and the transfer of vaccine technology have helped in introducing these vaccines where they are most needed."
10/06/2006 - "Derivation of simian-tropic HIV-1 (stHIV-1) has important implications for understanding primate lentivirus zoonosis and should allow the development of improved animal models for studies of AIDS and the evaluation of vaccines and treatments."
06/01/1990 - "This reagent and accompanying methods provide valuable assays for monitoring the efficacy of vaccines for SIV as a model for human AIDS."
02/20/2008 - "Using background data that live vaccines against several viral pathogens are effective in inducing life-long protection against disease, we undertook studies in macaques to determine the duration of protection that two live SHIV vaccines could induce against AIDS. "
01/01/2000 - "However, since the reports about effective treatment of AIDS and hope of development of vaccines, the biomedical paradigm has become a leading principle in many HIV/AIDS prevention programmes. "
|5.||Protease Inhibitors (Protease Inhibitor)IBA
07/01/2004 - "Although new treatments have significantly improved the physical health of those living with HIV/AIDS, no evidence was found that these treatments significantly improved psychological health for women, regardless of history of protease inhibitor use."
02/01/2002 - "Protease inhibitor combination therapies have significantly improved the health of many people with HIV/AIDS. "
09/01/1997 - "The safety and efficacy of two successive sessions of WBHT (4 days apart) was evaluated in 30 patients with AIDS (not on protease inhibitors), randomized to: 1) untreated controls, 2) low temperature WBHT for 1 hour at 40 degrees C and repeated 96 hours later, and 3) high temperature WBHT for 1 hour at 42 degrees C and repeated 96 hours later. "
10/01/2008 - "Therefore, the incomplete suppression of HIV in treatment-experienced AIDS patients will continue to drive the search for more effective therapeutic agents that exhibit efficacy against the mutants raised by the earlier generation of protease inhibitors. "
09/01/1997 - "Double protease inhibitor combinations may be effective in some AIDS patients who do not respond to or who are intolerant of routines with a single protease inhibitor, according to an in vitro study at Harvard. "
|6.||Itraconazole (Sporanox)FDA LinkGeneric
06/01/1997 - "Itraconazole cyclodextrin solution achieves higher serum itraconazole and hydroxy-itraconazole concentrations than the capsule formulation in AIDS patients, and this is associated with improved efficacy."
10/01/1999 - "Itraconazole solution can be effective in AIDS patients with C. "
07/01/2015 - "A computerised literature search was carried out using the PubMed, EMbase, Ovid, Web of Science, Science Direct and CNKI (China National Knowledge Infrastructure) databases to collect relevant articles (from their establishment date to August 2014) using the following keywords: Itraconaz or Sporanox, HIV, AIDS, Penicillium marneffei (PSM), and Treatment. "
02/01/2014 - "This paper presents a 35-year-old Brazilian male AIDS patient who developed pulmonary PCM successfully treated with itraconazole. "
04/01/2001 - "DNA fingerprinting of serial Candida albicans isolates obtained during itraconazole prophylaxis in patients with AIDS."
01/01/1985 - "We conclude that levels of antibody to sperm antigens are not significantly greater in homosexual men and antisperm antibody levels do not correlate with the diagnosis of AIDS."
03/16/1984 - "Patients with AIDS also had a significant reduction in their primary antibody response to the protein antigens. "
07/23/2009 - "This is the first demonstration that an IN defective SIV-based lentiviral vector provides effective immunization, thus paving the way for the construction of IN defective vectors expressing SIV antigen(s) and test their efficacy against a SIV virus challenge in the NHP model of AIDS."
01/01/2012 - "Based on the partial efficacy of the HIV/AIDS Thai trial (RV144) with a canarypox vector prime and protein boost, attenuated poxvirus recombinants expressing HIV-1 antigens are increasingly sought as vaccine candidates against HIV/AIDS. "
01/01/1988 - "HLA antigen frequencies in HIV-1 seropositive disease-free individuals and patients with AIDS."
06/15/1993 - "Transscleral iontophoresis of foscarnet may provide an effective and safe technique for local treatment of cytomegalovirus retinopathy in patients with acquired immunodeficiency syndrome."
03/24/1994 - "Efficacy of intravitreal foscarnet in a patient with AIDS."
08/01/1999 - "In the study, 20 patients with advanced stages of AIDS were treated with foscarnet 1% cream five times a day for a mean duration of 34.5 days. "
05/27/1999 - "Crystals in glomerular capillary lumens have also been observed in patients with acquired immunodeficiency syndrome who were treated with foscarnet for cytomegalovirus disease. "
11/01/1998 - "The genetic characterization of a foscarnet-resistant strain of varicella-zoster virus (VZV) that was isolated from a patient with AIDS is reported. "
|9.||Trimethoprim-Sulfamethoxazole Combination (Co-Trimoxazole)FDA LinkGeneric
01/01/2011 - "The provision of cotrimoxazole as a prophylaxis is an inexpensive and highly efficacious preventative intervention in HIV infected individuals, reducing both morbidity and mortality among adults and children with HIV/AIDS, yet evidence suggests that it has not been quickly or evenly scaled-up in resource poor settings. "
03/30/2008 - "The intervention remained cost-effective in all sensitivity analyses including routine haematological and CD4% monitoring, varying starting age, AIDS status, cotrimoxazole formulation, efficacy duration and discount rates. "
01/01/2014 - "Improved survival with co-trimoxazole prophylaxis among people living with HIV/AIDS who initiated antiretroviral treatment in Henan Province, China."
01/01/2014 - "The objective of the study was to evaluate the use of cotrimoxazole as preventive therapy in people living with HIV/AIDS in Boru Meda Hospital, Northeast Ethiopia. "
02/01/2006 - "The objective of this study was to assess the impact of medicines information on adherence to chronic co-trimoxazole therapy in low-literate HIV/AIDS patients. "
|10.||Doxorubicin (Adriamycin)FDA LinkGeneric
05/01/1994 - "A cooperative action of both mechanisms may explain the high efficacy of liposomal doxorubicin in the treatment of AIDS-KS."
08/01/2002 - "By contrast, a significant phenotype modification is detected in PBMCs from AIDS/KS patients after challenge with the liposomal formulation of the anthracycline doxorubicin (L-DOX) with the higher expression reached 24 hours after the end of the drug infusion. "
05/01/1999 - "In summary, our findings show that doxorubicin mediates, at least in part, its AIDS-KS cellular cytotoxic effects by a redox related mechanism, and provides a biochemical rationale for doxorubicin's clinical efficacy in AIDS-KS treatment."
05/01/1999 - "Although doxorubicin's mechanism of action against AIDS-KS is unknown, we hypothesized that doxorubicin's ability to undergo redox cycling is associated with its clinical efficacy. "
01/01/1996 - "Eighteen patients with AIDS-KS diagnosed by examination of biopsy specimens were randomly assigned to receive either standard doxorubicin or PEG-liposomal doxorubicin. "
|1.||Highly Active Antiretroviral Therapy (HAART)
09/01/2014 - "Since the introduction in 1996 of highly active anti-retroviral therapy (HAART), the landscape of malignancies associated to HIV/AIDS has changed in a significant manner as a direct result of significant improvement in the morbidity, mortality and life expectancy of HIV infected patients. "
06/01/2012 - "Although highly active anti-retroviral therapy (HAART) has obviously prohibited the progress of AIDS, a yearly increasing problems of human immunodeficiency virus (HIV) drug resistance have arousing more attention, affecting the clinical efficacy of HAART, and even resulting in treatment failure. "
01/01/2010 - "Highly active antiretroviral therapy (HAART) has dramatically improved health outcomes among people living with HIV/AIDS. "
06/01/2009 - "Although highly active antiretroviral therapy (HAART) has been extremely effective in lowering AIDS incidence among patients infected with HIV, certain drugs included in HAART can cause serious mitochondrial toxicities. "
06/19/2007 - "HAART has decreased the incidence of AIDS and death among HIV-infected individuals dramatically. "
05/01/1989 - "This study suggests that although condom availability has improved in the past year, the opportunity exists at most California public universities to increase the distribution of condoms and improve associated AIDS-related health education efforts. "
09/01/1998 - "Women who were not married, who worried about both pregnancy and AIDS, who had ever had an STD, who were confident they could refuse a sexual encounter in the absence of a condom and who made family planning decisions jointly with their partner were the most likely to use dual methods rather than a single method (odds ratios, 2.0-3.5); those who considered the condom only somewhat effective in preventing AIDS or who shared economic decision-making with their partner were the least likely to use dual methods rather than a single method (0.5-0.6). "
08/01/1992 - "When used properly, condoms are highly effective in preventing both pregnancy and the spread of HIV and AIDS, the public health community has therefore strongly promoted condom use for disease prevention. "
12/01/1990 - " From experience like these, the author provides the following conclusions and suggestions: 1) people without access to social services often fail to receive AIDS education; 2) many people speak only their native language, so the conventional approach of using English -- Nigeria's official language -- proves ineffective; 3) educational forums that allow people to raise questions are the most effective; 4) the provision of additional services can help attract people in public places; 5) besides discussing the importance of condom use in AIDS prevention and family planning, a demonstration of correct condom use often makes the talks more interesting; 6) condom accessibility and acceptability can be improved by using clubs and associations as forums for AIDS education; and 7) transferring some of the responsibility of AIDS education to the members of these clubs and associations can help spread the message."
05/01/1989 - " Although condom availability has improved in the past year, opportunities exist at most California public universities to increase the distribution of condoms and improve associated AIDS-related health education efforts."
|3.||Drug Therapy (Chemotherapy)
01/01/1996 - " Chemotherapy also effectively treated endemic African KS (partial or complete remission: 81% vs. 38% for AIDS-related KS). "
11/01/2008 - "This review highlights the significant potential that novel drug delivery systems have for the future effective treatment of HIV/AIDS patients on ARV drug therapy."
11/01/2008 - "This review highlights the significant potential that nanoparticles have for the future effective treatment of HIV/AIDS patients on ARV drug therapy."
01/01/2006 - "Among patients with systemic, AIDS-related NHL, there has been decreased high-grade histology, increased use of chemotherapy, and improved survival."
01/01/1995 - "The addition of chemotherapy to brain irradiation prolongs survival in some patients with AIDS-related disease, but median survival is not significantly improved."
03/01/2005 - "Although initiation of potent antiretroviral therapy (ART) has significantly improved immune perturbations in individuals with AIDS, it is unclear which factors are most important in determining the degree of immune reconstitution. "
08/01/2012 - "Fifteen years after recognition of the AIDS epidemic, the development of potent antiretroviral therapy (ART) resulted in a significant reduction in HIV-related morbidity and mortality for persons in resource-rich regions of the world. "
08/01/2012 - "Adherence to antiretroviral therapy (ART) has markedly improved HIV disease management, and significantly reduced HIV/AIDS-associated morbidity and mortality. "
01/01/2015 - "Although the last decade has seen a reduction in AIDS-related mortality worldwide, largely due to improved access to effective antiretroviral therapy (ART), AIDS remains a significant contributor to adolescent mortality in sub-Saharan Africa. "
01/01/2010 - "Currently there is no vaccine or cure for AIDS still Anti Retroviral Therapy (ART) is successful. "
11/01/1997 - "It was shown that Candida albicans bound in significantly greater numbers to epithelial cells obtained from AIDS patients than to those from healthy individuals or transplant patients, and that the adherence capacity varied among the strains tested."
09/01/2008 - "The new definition will be helpful in promoting better communication among transplant professionals and aids in comparing clinical studies of diagnostic techniques to identify DGF and thus may facilitate clinical trials of interventions for the treatment of DGF."
06/01/2013 - "The panelists' consensus was that a carefully designed skin graft transplant pilot experiment, in major histocompatibility complex (MHC) disparate male Mauritian cynomolgus macaques (MCM; Macaca fascicularis), would be useful for initially evaluating if alloimmunization results in an effective or even a partially effective safe AIDS vaccine. "
10/01/2010 - "Because impulse magnitude is mostly governed by the press-fit characteristics of the recipient site, this study aids in the definition of optimal insertion conditions for osteochondral grafts."
06/20/2002 - "Twelve patients were enrolled in this study, 10 with the acquired immunodeficiency syndrome and 2 who had received organ transplants. "