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Aconitate Hydratase (Aconitase)

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.
Also Known As:
Aconitase; Citrate Hydrolyase; Citrate Hydro Lyase; Hydratase, Aconitate; Hydro-Lyase, Citrate; Hydro-Lyase, Isocitrate; Hydrolyase, Citrate; Isocitrate Hydro Lyase; Citrate Hydro-Lyase; Isocitrate Hydro-Lyase; Citrate(isocitrate) hydro-lyase
Networked: 182 relevant articles (0 outcomes, 9 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Popova, T N: 11 articles (07/2014 - 08/2002)
2. Juang, Horng-Heng: 9 articles (01/2013 - 03/2004)
3. Tsui, Ke-Hung: 5 articles (01/2013 - 06/2005)
4. Matasova, L V: 5 articles (12/2012 - 08/2002)
5. Agarkov, A A: 4 articles (05/2015 - 10/2009)
6. Chang, Phei-Lang: 4 articles (01/2013 - 02/2006)
7. Szweda, Luke I: 3 articles (06/2015 - 04/2005)
8. Popov, S S: 3 articles (05/2015 - 08/2007)
9. Zweier, Jay L: 3 articles (01/2014 - 02/2006)
10. Feng, Tsui-Hsia: 3 articles (01/2013 - 06/2005)

Related Diseases

1. Neoplasms (Cancer)
2. Carcinoma (Carcinomatosis)
3. Seizures (Seizure)
01/01/2006 - "That a relative deficiency in GSH precedes later changes in the activities of complex I and aconitase in vulnerable hippocampal sub-regions, occurring within a clinically relevant therapeutic time window, suggests that strategies to boost GSH levels and/or otherwise reduce oxidative stress following seizures, deserve further study, both in terms of preventing the biochemical consequences of SE and the neuronal dysfunction and clinical consequences."
03/01/2004 - "Before the age at which spontaneous seizures appear in a subset of the mice, Sod2(-/+) mice demonstrated increased susceptibility to behavioral seizures, mitochondrial aconitase inactivation, and neurodegeneration induced by the administration of kainate. "
01/01/2003 - "Kainate-induced seizures resulted in increased mitochondrial aconitase inactivation and 8-OHdG formation in adult (postnatal day 30 or more), but not in immature rats (postnatal days 12 and 21). "
06/01/2004 - "The data demonstrate that inhibition of aconitase in astrocytes lowers the doses of both kainic acid and pilocarpine that will cause behavioral seizures and may increase neuronal vulnerability to seizures."
03/01/2004 - "We demonstrate here that a subset of mice with partial deficiency of the mitochondrial superoxide dismutase (Sod2(-/+)) show increased incidence of spontaneous and handling-induced seizures that correlates with chronic mitochondrial oxidative stress (increased aconitase inactivation and 8-hydroxy-2'-deoxyguanosine formation in mitochondria) and diminished mitochondrial oxygen utilization. "
4. Muscular Diseases (Myopathy)
5. Adenocarcinoma

Related Drugs and Biologics

1. Superoxides (Superoxide)
2. Succinate Dehydrogenase (Fumarate Reductase)
3. Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
4. Fumarate Hydratase (Fumarase)
5. Oxidoreductases
6. DNA (Deoxyribonucleic Acid)
7. L-Lactate Dehydrogenase (Lactate Dehydrogenase)
8. Guanidine (Guanidine Nitrate)
9. Vitamin E
10. Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)

Related Therapies and Procedures

1. Ligation
2. Fluid Therapy (Oral Rehydration Therapy)
3. Aftercare (After-Treatment)