Aconitate Hydratase (Aconitase)

An enzyme that catalyzes the reversible hydration of cis-aconitate to yield citrate or isocitrate. It is one of the citric acid cycle enzymes. EC 4.2.1.3.

Also Known As:

Aconitase; Citrate Hydrolyase; Citrate Hydro Lyase; Hydratase, Aconitate; Hydro-Lyase, Citrate; Hydro-Lyase, Isocitrate; Hydrolyase, Citrate; Isocitrate Hydro Lyase; Citrate Hydro-Lyase; Isocitrate Hydro-Lyase; Citrate(isocitrate) hydro-lyase

Networked: 286 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Lyases: 637
    - Carbon-Oxygen Lyases
      - Hydro-Lyases: 266
        Aconitate Hydratase: 286
        Iron Regulatory Protein 2: 46
        Iron Regulatory Protein 1: 41
        bacteria RpfA protein
        human ACO2 protein
        Legionella pneumophila ACN protein
        mouse aconitase 2
        Plasmodium falciparum IRPa protein
        S pombe Aco2 protein

Experts

1.	Popova, T N: 14 articles (03/2019 - 08/2002)
2.	Juang, Horng-Heng: 9 articles (01/2013 - 03/2004)
3.	Matasova, L V: 6 articles (12/2012 - 08/2002)
4.	Popov, S S: 5 articles (05/2015 - 12/2005)
5.	Tsui, Ke-Hung: 5 articles (01/2013 - 06/2005)
6.	Agarkov, A A: 4 articles (05/2015 - 10/2009)
7.	Pashkov, A N: 4 articles (05/2015 - 12/2005)
8.	Chang, Phei-Lang: 4 articles (01/2013 - 02/2006)
9.	Semenikhina, A V: 4 articles (12/2012 - 12/2005)
10.	Zhang, Wei: 3 articles (12/2021 - 10/2014)

Related Diseases

1.	Obesity 01/01/2017 - "Our results revealed that high fat diet intake promoted obesity, marked decrease in fractional shortening, and cardiomyocyte contractile capacity with dampened intracellular Ca2+ release and clearance, elevated ROS generation and oxidative stress as measured by aconitase activity, the effects of which were significantly attenuated by TLR4 knockout. " 06/30/2015 - "Using in vitro strategies, mass spectrometric analyses, and an in vivo mouse model of obesity, we found a significant acetylation-dependent activation of aconitase. " 10/31/2018 - "This network included aconitate hydratase 2 (ACO2), and dihydrolipoyl dehydrogenase (DLD), in which acetylation was significantly increased by obesity. " 08/01/2010 - "Our objective in this study was to determine whether a mitochondria-targeted vitamin E derivative (MitoVit E) would decrease oxidative stress and associated obesity by preventing a previously proposed aconitase inhibition cascade. "
2.	Hypoxia (Hypoxemia) 02/12/1999 - "Hypoxia also decreased cytosolic aconitase activity. " 01/01/2013 - "Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells." 01/01/2020 - "However, hypoxia-acclimated fish exhibited little to no oxidative damage (as reflected by lipid peroxidation and aconitase activity), in association with improvements in scavenging capacity and catalase activity in muscle. " 01/01/2020 - "The amount of inactivation of mitochondrial aconitase during hypoxia was also dependent upon AOX amount, perhaps through its effects on NO amount, and this influenced carbon flow under hypoxia. " 11/01/2010 - "In synaptosomes from young animals, chronic hypoxia induced a decrease in mitochondrial aconitase activity and GSH levels and an increase in CuZnSOD activity and GSSG levels. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2019 - "Reduced aconitase activity directly suppresses the TCA cycle, resulting in mitochondrial dysfunction, which may lead to symptoms similar to those observed in mitochondrial diseases." 01/01/2018 - "Mitochondrial aconitase is very sensitive to oxidative inactivation and can aggregate and accumulate in the mitochondrial matrix causing mitochondrial dysfunction. " 10/19/2022 - "Umbilical cord-derived MSCs of ELBW infants who later died or developed moderate/severe BPD had lower oxygen consumption and aconitase activity but higher extracellular acidification-indicative of mitochondrial dysfunction and increased oxidant stress-when compared to MSCs from infants who survived with no/mild BPD. " 01/01/2021 - "ACONITASE 3 is part of theANAC017 transcription factor-dependent mitochondrial dysfunction response." 04/01/2013 - "Disturbances in mitochondrial enzyme complexes (I-IV) and decrements in TCA enzymes (ICDH, SDH, and aconitase) were noted in discrete brain regions upon F exposure, suggesting mitochondrial dysfunction. "
4.	Neoplasms (Cancer) 12/01/2020 - "A significant fraction of these neoplasms harbor deletions on the locus 9p21, targeting the tumor suppressor CDKN2A but also deleting the aconitase 1 (ACO1) gene, a neighboring housekeeping gene involved in cytoplasm and mitochondrial metabolism. " 07/01/1988 - "Moreover, the specific activities of aconitate hydratase in both cytoplasm and mitochondria decrease when the tumor progresses in the peritoneum of BALB/C mice, as well as the percentage of aconitate hydratase activity in the presence of oxalacetate as the inhibitor. " 09/01/1986 - "Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. " 07/01/1988 - "Characterization of aconitate hydratase from mitochondria and cytoplasm of ascites tumor cells." 07/01/1988 - "Since aconitate hydratase is not a key enzyme, these unexpected data are of interest in the study of cancer biochemistry."
5.	Carcinoma (Carcinomatosis) 01/01/2011 - "p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells." 03/01/2004 - "Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells." 01/01/2013 - "Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells." 05/01/2006 - "To investigate the possible role of manganese in the regulation of mitochondrial aconitase (mACON) activity human prostate carcinoma cell line PC-3 cells. " 02/01/2006 - "Zinc blocks gene expression of mitochondrial aconitase in human prostatic carcinoma cells."

Related Drugs and Biologics

1.	S-Nitrosothiols
2.	Nitrites
3.	Enzymes
4.	Proteins (Proteins, Gene)
5.	Iron
6.	Succinate Dehydrogenase (Fumarate Reductase)
7.	Superoxides (Superoxide)
8.	Free Radicals
9.	Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))
10.	Fumarate Hydratase (Fumarase)

Related Therapies and Procedures

1.	Therapeutics
2.	Ligation
3.	Fluid Therapy (Oral Rehydration Therapy)
4.	Aftercare (After-Treatment)