|4.||Psoriasis (Pustulosis Palmaris et Plantaris)
|5.||Rosacea (Acne Rosacea)
|1.||Zouboulis, Christos C: 46 articles (11/2015 - 03/2002)|
|2.||Del Rosso, James Q: 44 articles (06/2015 - 08/2002)|
|3.||Feldman, Steven R: 36 articles (11/2015 - 10/2003)|
|4.||Gold, Michael H: 27 articles (12/2015 - 07/2002)|
|5.||Leyden, James J: 27 articles (06/2014 - 01/2002)|
|6.||Thiboutot, Diane: 27 articles (05/2014 - 05/2002)|
|7.||Thiboutot, Diane M: 26 articles (06/2015 - 01/2003)|
|8.||Zouboulis, C C: 21 articles (07/2015 - 03/2000)|
|9.||Shalita, Alan R: 20 articles (12/2012 - 05/2003)|
|10.||Cunliffe, W J: 19 articles (05/2007 - 05/2000)|
|1.||Isotretinoin (Accutane)FDA LinkGeneric
10/01/2015 - "Isotretinoin is known to be the most effective treatment of severe and persistent acne. "
07/01/2015 - "Isotretinoin is the strongest, most effective oral treatment for patients with severe acne vulgaris, with remission rates of 89% and higher. "
01/01/2014 - "In the 1970s, the onset of isotretinoin dramatically improved acne management. "
12/01/2013 - "Isotretinoin is the most effective treatment for acne. "
04/01/2013 - "Isotretinoin has been the most effective and long-lasting drug for the treatment of severe acne for more than 30 years and can achieve long-term remission in 70-80 % of patients after a single course. "
|2.||Benzoyl PeroxideFDA LinkGeneric
07/01/1979 - "The results of an open clinical trial of 200 patients in Singapore show that benzoyl peroxide, in a stable gel formulation, both in 2.5% and 5% strengths, was highly efficacious in the topical treatment of acne vulgaris without concomitant systemic therapy. "
07/01/2009 - "Benzoyl peroxide has a proven track record of safety and efficacy for the treatment of acne. "
07/01/2000 - "Despite many functions beneficial in acne therapy, benzoyl peroxide does not possess sebosuppressive capabilities. "
12/01/2015 - "Over-the-counter acne treatments have assumed more importance for the dermatologist as access and affordability of prescription acne medications has decreased.<br /> This research evaluated the efficacy of a three step acne treatment regimen containing stabilized botanical anti-inflammatory ingredients as compared to a currently marketed acne regimen.<br /> 80 female/male subjects 12+ years with mild to moderate acne (at least 10 inflammatory and 10 non-inflammatory lesions) were enrolled for 12 weeks and randomized to use the study botanical anti-inflammatory acne regimen or the traditional benzoyl peroxide comparator. "
01/01/1980 - "The results of our study have shown that this new, higher concentration formulation of benzoyl peroxide is effective in reducing the lesions of acne and is relatively nonirritating."
|3.||adapalene (Differin)FDA LinkGeneric
05/01/2008 - "Adapalene gel 0.1% was found to be a highly effective and safe drug in the treatment of mild-to-moderate infantile acne."
08/01/2007 - "A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies."
06/01/2013 - "More subjects using adapalene-BPO reported that their acne had no effect on their quality of life, and parents noted that their child's acne significantly improved. "
08/01/2012 - "Overall, patients with mild to moderate acne treated with adapalene-BPO gel showed significant improvement in disease severity and quality of life. "
08/01/2011 - "In conclusion, the fixed-dose adapalene-BPO combination gel provides synergistic and significantly greater efficacy than its monotherapies in the treatment of acne vulgaris."
|4.||Tretinoin (Retinoic Acid)FDA LinkGeneric
04/01/2014 - "While tretinoin has demonstrated proven efficacy in the treatment of acne lesions, it also is associated with the potential for skin irritation. "
05/01/2006 - "The therapeutic efficacy of the tretinoin products Tretin-X (Triax Pharmaceuticals, Cranford, NJ) and Retin-A (Johnson & Johnson, New Brunswick, NJ) in the treatment of acne vulgaris was compared in four bioequivalence studies. "
02/01/1998 - "Topical tretinoin is effective treatment for both acne and photoaging. "
10/01/1986 - "It was reported in 1969 that topical tretinoin was effective in acne vulgaris, principally by preventing and dislodging comedones. "
07/01/2004 - "Improved efficacy and tolerability of retinoic acid in acne vulgaris: a new topical formulation with cyclodextrin complex psi."
02/01/2011 - "There was a significant reduction in the number of inflammatory acne lesions after PDT, compared to baseline (p<0.05). "
03/01/2010 - "PDT with the treatment regimen employed here may be beneficial for a subgroup of patients with inflammatory acne."
01/01/2007 - "MAL-PDT using IPL and MAL in Asians did not lead to significant improvement of moderate inflammatory acne compared with the control group. "
04/01/2006 - "PDT appeared to be an effective treatment for inflammatory acne vulgaris with no significant differences in the response rate between ALA-PDT and MAL-PDT. "
12/01/2005 - "ALA-PDT with red light was found to be effective in the reduction of the number of inflamed lesions in patients with mild-to-moderate acne vulgaris, with no significant short-term adverse effects."
|6.||Clindamycin (Cleocin)FDA LinkGeneric
10/01/2009 - "In our pilot clinical study, we have compared the efficacy of TauBr cream with clindamycin gel, one of the most common topical agents used in the treatment of acne. "
08/01/1981 - "Also, more patients who were receiving clindamycin thought their acne improved by week 8 (with significantly higher change-in-acne scores) than did the patients receiving placebo. "
01/01/2010 - "The efficacy of clindamycin in acne treatment has been shown to be sustained for more than 3 decades. "
08/01/1981 - "These results substantiate the clinical impression that topical clindamycin is effective treatment for acne."
08/01/2009 - "Clindamycin-BP 2.5% aqueous gel is an effective and safe once-daily treatment for moderate or severe acne."
|7.||Anti-Bacterial Agents (Antibiotics)IBA
01/01/1981 - "Modern therapy for acne includes various topical agents highly effective against noninflammatory lesions, and oral or topical antibiotics effective against the inflammatory lesions. "
07/01/2011 - "Propionibacterium acnes plays an important role in the development of acne, and inflammatory lesions are improved by antibiotics. "
09/01/2008 - "Although topical therapies alone can be very effective for milder acne, there are often cases for which oral antibiotics are needed to control disease. "
09/01/2014 - "Both antibiotics and oral contraceptive pills (OCPs) have been found to be effective in managing acne vulgaris. "
03/01/2013 - "Systemic antibiotics are an effective treatment for acne vulgaris. "
09/01/2008 - "Topical retinoids are highly effective in the treatment of both comedonal and inflammatory lesions of acne and are a vital part of almost any acne regimen. "
01/01/2008 - "The broad anti-acne activity and safety profile of topical retinoids justifies their use as first-line treatment in most types of non-inflammatory and inflammatory acne. "
02/01/2005 - "Despite published data showing the efficacy of topical retinoids in treating inflammatory acne, in clinical practice topical retinoids tend to be used most commonly for noninflammatory acne. "
01/01/2003 - "When added to antibacterial therapy, topical retinoids demonstrate faster and significantly greater reduction of inflammatory acne lesions and comedones than antibacterials alone."
09/01/2007 - "Topical retinoids normalize desquamation, reduce comedogenesis and may enhance the penetration of other topicals providing more effective treatment of acne. "
|9.||Minocycline (Cyclops)FDA LinkGeneric
10/01/2006 - "For a long time, minocycline has been recognized as highly efficacious for the treatment of acne vulgaris but with use-limiting acute vestibular adverse events (AVAEs). "
01/01/1985 - "Once again Minocin treatment resulted in a highly significant improvement trend (p less than 0.0001) in the severity of acne. "
01/01/2012 - "Minocycline is an effective treatment for moderate to moderately-severe inflammatory acne vulgaris, but there is still no evidence that it is superior to other commonly-used therapies. "
01/01/2010 - "Formerly, minocycline was thought to have a superior efficacy in the treatment of inflammatory acne, especially with respect to antibacterial-resistant Propionibacterium acnes. "
09/01/2003 - "Minocycline is an effective treatment of acne vulgaris, especially for inflammatory forms. "
|10.||Erythromycin (Erycette)FDA LinkGeneric
08/01/2005 - "There is a gradual decrease in the efficacy of topical erythromycin in clinical trials of therapeutic intervention for acne, which is probably related to the development of antibiotic-resistant propionibacteria."
01/01/2012 - "Efficacy of intense pulsed light combined with topical erythromycin solution 2% versus topical erythromycin solution 2% alone in the treatment of persistent facial erythematous acne macules."
09/01/2001 - "All but two infants with moderate acne responded well to oral (paediatric) erythromycin 125 mg twice daily and topical therapy. "
05/01/1982 - "The efficacy of a topical preparation containing erythromycin in the treatment of acne."
08/01/2005 - "Analysis of clinical studies investigating the effect of topical erythromycin in acne patients indicates a significant decrease in the effect of this antibiotic on inflammatory and noninflammatory lesion count over time (r = -2.140, P = 0.001 and r = -2.032, P = 0.001, respectively). "
01/01/2011 - "Many laser and light-based treatments have shown excellent clinical results in the reduction of inflammatory acne lesions and improved acne severity. "
01/01/2015 - "Significant improvement in acne was seen in both the combined (laser and peel) and chemical peel alone treatment arms (P < .0005 and P = .001). "
04/01/2012 - "This laser treatment was rapid and effective for treating not only the inflammatory but also the noninflammatory acne lesions when compared with the control side. "
12/01/2006 - "All patients had a reduction in the inflammatory acne lesion count on the laser-treated side, which was statistically significantly greater on the laser-treated side compared with the side treated physically (p=0.039, Wilcoxon signed ranks test). "
07/01/2006 - "Significant improvement in acne lesion counts were noted after the first treatment and was maintained 12 months after the third treatment, indicating significant long-term clinical remission after laser treatment."
|2.||Photochemotherapy (Photodynamic Therapy)
01/01/2007 - "Photodynamic therapy with 5-aminolevulinic acid and recently methyl aminolevulinate has been shown to be a safe and effective modality for the treatment of acne vulgaris. "
11/01/2005 - "Cystic acne improved by photodynamic therapy with short-contact 5-aminolevulinic acid and sequential combination of intense pulsed light and blue light activation."
10/01/2013 - "Short-term clinical effects of photodynamic therapy with topical 5-aminolevulinic acid for facial acne conglobata: an open, prospective, parallel-arm trial."
01/01/2009 - "This controlled study investigated single low-dose red light photodynamic therapy and methyl-aminolevulinate (MAL) for treatment of moderate to severe facial acne in 19 patients. "
06/01/2007 - "More and more clinical trials are showing the effectiveness of 5-aminolevulinic acid and photodynamic therapy in the treatment of moderate to severe inflammatory acne vulgaris."
11/01/2009 - "To date, reports on the safe and effective treatment of severe inflammatory facial acne with the low-fluence 1064 nm Nd:YAG laser are limited.The"
12/01/2011 - "532-nm KTP laser treatment may be an alternative method in selected acne vulgaris patients. "
12/01/2011 - "To evaluate the efficacy and safety of 532-nm KTP laser and compare the effects of once and twice weekly applications in the treatment of mild to moderate acne vulgaris. "
12/01/2011 - "Evaluation of 532-nm KTP laser treatment efficacy on acne vulgaris with once and twice weekly applications."
11/01/2009 - " authors report a case of treatment for severe inflammatory acne in a pregnant Asian female (Fitzpatrick skin type IV) with the low fluence 1064 nm Nd-YAG laser.These"
04/01/2009 - "Use of multiple passes of a 1,450-nm diode laser with lower fluence and shorter dynamic cooling device retains its therapeutic efficacy with substantial reduction of PIH for moderate acne."
07/01/2006 - "The 1450-nm diode laser has been known to thermally alter sebaceous glands and has been found to be effective for the treatment of inflammatory facial acne. "
02/01/2004 - "The 1450-nm diode laser has been found to damage sebaceous glands selectively and to be effective for the treatment of inflammatory acne on the back. "
02/01/2009 - "This study aimed to evaluate the clinical efficacy of low-energy, double-pass, 1450 nm diode laser treatment in the treatment of acne in Asian patients. "
08/01/2008 - "The 1,450-nm diode laser has been shown to improve acne in a study setting. "
|5.||Phototherapy (Light Therapy)
11/01/2002 - "The purpose of this study was to investigate the efficacy of phototherapy with a newly-developed high-intensity, enhanced, narrow-band, blue light source in patients with mild to moderate acne. "
05/01/2013 - "This LED phototherapy was safe and effective for treating not only inflammatory but also noninflammatory acne lesions, with good compliance. "
06/01/2003 - "The data show more than an 80% response to 420 nm acne phototherapy with a significant reduction of 59-67% of inflammatory acne lesions after only eight treatments of 8-15 minutes. "
10/01/2007 - "Red light phototherapy alone is effective for acne vulgaris: randomized, single-blinded clinical trial."
02/01/2007 - "Targeted blue light phototherapy with MultiClear is effective for the treatment of inflammatory acne lesions. "