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Lactic Acidosis

Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as DIABETES MELLITUS; LEUKEMIA; or LIVER FAILURE.
Also Known As:
Acidosis, Lactic
Networked: 3887 relevant articles (135 outcomes, 208 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hypoglycemia (Reactive Hypoglycemia)
2. Renal Insufficiency (Renal Failure)
3. Neoplasms (Cancer)
4. Stroke (Strokes)
5. Acidosis

Experts

1. Stacpoole, Peter W: 13 articles (01/2020 - 04/2003)
2. Sperl, Wolfgang: 12 articles (09/2018 - 10/2005)
3. Prokisch, Holger: 12 articles (01/2018 - 08/2011)
4. Haack, Tobias B: 11 articles (01/2018 - 08/2011)
5. Zeviani, Massimo: 11 articles (01/2018 - 01/2002)
6. Protti, Alessandro: 10 articles (01/2021 - 01/2010)
7. Taylor, Robert W: 10 articles (01/2020 - 10/2002)
8. Mayr, Johannes A: 10 articles (09/2018 - 03/2007)
9. Meitinger, Thomas: 10 articles (01/2018 - 02/2012)
10. Lalau, Jean-Daniel: 9 articles (12/2020 - 09/2010)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lactic Acidosis:
1. Metformin (Glucophage)FDA LinkGeneric
2. Lactic Acid (Lactate)FDA LinkGeneric
3. Thiamine (Aneurin)FDA Link
4. Glucose (Dextrose)FDA LinkGeneric
5. Oxygen (Dioxygen)IBA
11/01/2007 - "Peak oxygen uptake and lactic acidosis threshold improved significantly in the supervised groups, but differences among groups did not achieve significance. "
02/01/2018 - "Some investigators have sought to capitalize on this mechanism with promising results, as evidenced by microcirculatory vasodilation, improvements in regional blood flow and oxygen delivery, and reductions in lactic acidosis, organ failure, and mortality. "
01/01/2021 - "In particular, a sufficiently large (at a given work intensity) decrease in OXPHOS activity leads to slowing of the primary phase II of the oxygen uptake (V̇o2) on-kinetics, decrease in maximal V̇o2 (V̇o2max), appearance of the slow component of the V̇o2 on-kinetics, exercise intolerance, and lactic acidosis at relatively low power outputs encountered in experimental studies in patients with MM. Thus, the "Pi double-threshold" mechanism of muscle fatigue is able to account, at least semiquantitatively, for various kinetic effects of inborn OXPHOS deficiencies of the skeletal muscle bioenergetic system. "
11/01/2010 - "This mechanism is also supported in some studies by a critically low oxygen uptake that was not associated with lactic acidosis."
07/01/2000 - "Results of a progressively increasing CPX can be used to: 1) design an exercise prescription for aerobic training in HIV+ individuals; 2) identify and refer patients with subtle abnormalities of gas exchange for further diagnostic studies to exclude early infectious complications: and 3) evaluate the improvements in maximal oxygen uptake, lactic acidosis threshold, and gas exchange kinetics as result from an aerobic exercise training program. "
6. NucleosidesIBA
7. Phenformin (Fenformin)IBA
8. Insulin (Novolin)FDA Link
9. AcidsIBA
10. Sodium Bicarbonate (Baking Soda)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Renal Dialysis (Hemodialysis)
3. Drug Therapy (Chemotherapy)
4. Resuscitation
5. Continuous Renal Replacement Therapy