Lactic Acidosis

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2097 relevant articles (66 outcomes, 102 trials/studies) found for this Disease

Description: Acidosis caused by accumulation of lactic acid more rapidly than it can be metabolized. It may occur spontaneously or in association with diseases such as diabetes mellitus, leukemia, or liver failure.

Also Known As:

Acidosis, Lactic

Relationship Network

Disease Context: Research Results

Nutritional and Metabolic Diseases

Metabolic Diseases: 1264

Acid-Base Imbalance: 63

Acidosis: 8945

Lactic Acidosis: 2097

Related Diseases

1.	Hypoglycemia (Reactive Hypoglycemia)
2.	Stroke (Strokes)
3.	Mitochondrial Myopathies (Mitochondrial Myopathy)
4.	Shock
5.	Pancreatitis
362 Diseases and 1113 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Stacpoole, Peter W: 3 articles (05/2008 - 04/2003)
2.	Ichai, C: 3 articles (10/2006 - 05/2003)
3.	Greyber, E: 3 articles (01/2006 - 01/2002)
4.	Salpeter, E: 3 articles (01/2006 - 01/2002)
5.	Salpeter, S: 3 articles (01/2006 - 01/2002)
6.	Pasternak, G: 3 articles (01/2006 - 01/2002)
7.	Brivet, Michèle: 3 articles (04/2005 - 04/2003)
8.	Almirall, Jaume: 2 articles (07/2008 - 06/2002)
9.	Runge, S: 2 articles (07/2008 - 01/2008)
10.	Valenstein, Edward: 2 articles (05/2008 - 05/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lactic Acidosis:

1.	Dichloroacetate (Dichloroacetic Acid)IBA 01/01/1988 - "Sodium dichloroacetate (NaDCA) has been used successfully to treat clinical and experimentally-induced lactic acidosis" 05/01/2006 - "OBJECTIVE: Open-label studies indicate that oral dichloroacetate (DCA) may be effective in treating patients with congenital lactic acidosis" 08/18/1983 - "We conclude that dichloroacetate is a safe and effective adjunct in the treatment of patients with lactic acidosis, although the ultimate prognosis may depend on the underlying disease." 01/01/1990 - "Reduction in spinal cord postischemic lactic acidosis and functional improvement with dichloroacetate." 04/01/1986 - "Although dichloroacetate (DCA) ameliorates type B lactic acidosis, its effectiveness in type A hypoxic lactic acidosis is uncertain on both theoretical and experimental grounds" Get all the results and reference details, order at left...
2.	Lactic Acid FDA LinkGeneric 08/01/1999 - "The present study was designed to investigate the efficacy of control of lactic acidosis by immunisation against lactic acid-producing bacteria, Streptococcus bovis and Lactobacillus" 10/01/2006 - "Hemofiltration was titrated upward until lactic acidosis resolved, through clearance of lactate or interruption of excess cytokine-driven activity; maximum prescription was 2000 mL/h ultrafiltrate production plus 2500 mL/h dialysate flow" 02/01/1983 - "The D-lactic acidosis was cleared using antibiotic therapy, suggesting that D-lactate is produced from fermentation of ingested carbohydrate by colonic bacteria" 01/01/2004 - "SIGNIFICANCE AND IMPACT OF THE STUDY: Streptococcus bovis is considered a key lactic acid producing bacterium from the gastrointestinal tract of ruminants, and has been implicated as a causative agent of lactic acidosis" 06/01/2002 - "This study evaluated the reliability and validity of the lactate minimum test (LMT), an incremental test given after lactic acidosis was induced by sprint exercise" Get all the results and reference details, order at left...
3.	Metformin (Glucophage)FDA LinkGeneric 09/01/2005 - "OBJECTIVE: In this report of a near-fatal metformin ingestion successfully treated with alkalinization and high-volume hemofiltration, we discuss the management of severe lactic acidosis and demonstrate that early aggressive intervention resulted in a positive outcome" 03/01/2000 - "In France, Information given to physicians, pharmacists and patients on the risk of lactic acidosis where Glucophage is implicated must be improved, and on the interest of the metformin plasma level in this case" 11/01/2008 - "RESULTS: Among the study population of 50,048 type 2 diabetic subjects, six cases of lactic acidosis during current use of oral antidiabetes drugs were identified, yielding a crude incidence rate of 3.3 cases per 100,000 person-years among metformin users and 4.8 cases per 100,000 person-years among users of sulfonylureas" 07/01/2008 - "Prevalence of risk determinants for metformin-associated lactic acidosis and metformin utilization in the study of health in pomerania." 04/21/2008 - "Metformin and lactic acidosis in an Australian community setting: the Fremantle Diabetes Study." Get all the results and reference details, order at left...
4.	Phenformin (Fenformin)IBA 04/01/1998 - "Efficacy of continuous venovenous haemofiltration (CVVH) in the treatment of severe phenformin-induced lactic acidosis." 12/01/1983 - "The results may help to explain lactic acidosis in patients given phenformin in the absence of other predisposing factors." 09/01/1979 - "Detailed hemodynamic and metabolic studies were performed during the course of phenformin related lactic acidosis in two patients" 02/01/2008 - "Two of the patients presented with potentially fatal phenformin-induced lactic acidosis" 04/01/2006 - "Phenformin-induced lactic acidosis in an older diabetic patient: a recurrent drama (phenformin and lactic acidosis)." Get all the results and reference details, order at left...
5.	Glucose (Dextrose)FDA LinkGeneric 06/01/2002 - "Recent studies provide evidence of direct consumption of glucose by the tumour cells, leading to lactic acidosis" 03/12/1999 - "Plasma glucose concentration was altered in individual animals to study a range of intraischemic cerebral lactic acidosis" 09/01/1998 - "Plasma glucose concentrations were elevated in order to study animals with severe cerebral lactic acidosis" 01/01/1978 - "Studies on fibroblasts from patients with lactic acidosis of different causes showed secondary metabolic changes in pathways of glucose metabolism" 09/01/2002 - "Thus, continuous parenteral infusion of glucose solution at an early stage after exposure may be an effective clinical therapy for the prevention of hypoglycaemia and metabolic lactic acidosis caused by MCA." Get all the results and reference details, order at left...
6.	OxygenIBA 11/01/2007 - "Peak oxygen uptake and lactic acidosis threshold improved significantly in the supervised groups, but differences among groups did not achieve significance" 02/01/2007 - "At a target pressure of 40 mmHg, the initial blood pressure response to oxygen is the same, but it gradually decreases as the animal develops a lactic acidosis" 12/16/2006 - "Lymphoreticular malignancies should be considered for cases of lactic acidosis with sufficient oxygen supply, particularly when hypoglycaemia is also present" 03/01/2006 - "The commonest metabolic complications (lactic acidosis and hypoglycaemia) arise from increased host anaerobic metabolism probably due to a mismatch between tissue oxygen supply and requirement" 10/01/2004 - "It is likely that lactic acidosis markedly increased oxygen availability, which when associated with the slow linear increase of Q(.), may account for the V(.)O(2) slow component" Get all the results and reference details, order at left...
7.	Sodium Bicarbonate (Baking Soda)FDA LinkGeneric 12/01/1991 - "Sodium bicarbonate has been thought to be effective for hypoxic lactic acidosis, but recently its adverse reactions have been pointed out" 09/01/2000 - "Sodium bicarbonate controversy in lactic acidosis." 01/01/2000 - "Sodium bicarbonate for the treatment of lactic acidosis." 03/01/1999 - "Immediately after surgery, she developed severe lactic acidosis, which required correction with sodium bicarbonate solution and ventilatory support for 36 hours" 01/01/1994 - "Rationale for the use of sodium bicarbonate in a patient with lactic acidosis due to a poor cardiac output." Get all the results and reference details, order at left...
8.	Thiamine (Aneurin)FDA Link 02/01/1997 - "Thiamine replenishment at intravenous doses of 100 mg every 12 h resolved lactic acidosis and improved the clinical condition in 3 patients" 01/01/1991 - "In both patients, the lactic acidosis improved immediately, and it disappeared following the second dose of thiamine" 08/01/2005 - "Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies." 05/10/2008 - "Severe lactic acidosis due to deficit of thiamine]" 08/01/2005 - "Although the clinical features of thiamine-responsive congenital lactic acidosis are heterogeneous and clinical responses to thiamine administration vary, we emphasize the importance of early diagnosis and initiation of thiamine therapy before the occurrence of permanent brain damage" Get all the results and reference details, order at left...
9.	Insulin (Novolin)FDA Link 08/01/1990 - "In two young female diabetics treated with insulin lactic acidosis developed" 08/01/1990 - "Benign lactic acidosis in 2 female diabetics treated with insulin]" 03/01/1977 - "The present report describes a patient with insulin-dependent diabetes who developed simultaneously lactic acidosis and ketoacidosis following insulin deprivation" 01/01/1975 - "For the lactic acidosis which results, insulin administration may thus constitute specific therapy" 01/01/2008 - "CONCLUSIONS: Type B lactic acidosis is a phenomenon that may occur in the pediatric population in conjunction with insulin-resistant hyperglycemia" Get all the results and reference details, order at left...
10.	CreatinineIBA 05/15/2003 - "According to these results, monitoring of creatinine clearance, especially in patients with a low nadir CD4+ T lymphocyte count, could lead to modifications in antiretroviral therapy in order to diminish the risk of occurrence of lactic acidosis." 06/01/1996 - "Risk factors for lactic acidosis include renal serum creatinine > 1.5 mg/dL and cardiovascular, pulmonary, and hepatic disease" 04/07/1981 - "Lactic acidosis may occur even in the presence of almost normal serum creatinine concentrations." 07/01/1979 - "Fourteen of the patients had a normal serum creatinine concentration either before or after the development of lactic acidosis" 05/01/1975 - "All patients with combined lactic acidosis and ketoacidosis excreted 2-HB in the urine, in amounts up to 2.3 mmol/mmol creatinine" Get all the results and reference details, order at left...
567 Drugs and Important Bio-Agents and 1983 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Renal Dialysis (Hemodialysis) 09/01/1996 - "After hemodialysis and clearance of toxic metabolites, severe lactic acidosis persisted with multiorgan failure" 09/01/1978 - "The efficacy of hemodialysis in the treatment of biguanide-induced lactic acidosis is difficult to evaluate" 01/01/1991 - "DCA can safely and effectively be given to hemodialysis patients who may require the drug for treatment of lactic acidosis." 01/01/1980 - "In an observation with very severe evolution, various ischemic localizations inducing amputation, two intestinal resections and an hemodialysis for lactic acidosis were noted" 12/01/1996 - "Patients recovered from renal failure and lactic acidosis without hemodialysis" Get all the results and reference details, order at left...
2.	Resuscitation 01/01/2006 - "RESULTS: All resuscitation strategies restored blood pressure, but clearance of lactic acidosis was impeded following DL-LR resuscitation" 10/05/2005 - "There is increasing recognition, however, of a group of acidotic patients who have a large anion gap that is not explained by either keto- or lactic acidosis nor, in most cases, is inappropriate fluid resuscitation or ingestion of exogenous agents the cause" 11/01/1999 - "In the prospective study, patients with two consecutive LA levels greater than 2.5 mmol/L underwent invasive monitoring and vigorous resuscitation to correct their lactic acidosis" 11/01/1991 - "INTERVENTIONS AND MAIN RESULTS: All patients underwent invasive hemodynamic monitoring followed by volume resuscitation and inotropic support to reverse flow-dependent oxygen consumption and lactic acidosis" 12/01/1982 - "Certain aspects of these cases, such as delayed entrance into the medical care system and exercise-induced lactic acidosis, make successful resuscitation difficult" Get all the results and reference details, order at left...
3.	Drug Therapy (Chemotherapy) 05/01/1983 - "Chemotherapy against the neoplastic disease is the only effective treatment of this type of lactic acidosis." 12/16/2006 - "Tumour reduction with chemotherapy can reduce the lactic acidosis." 11/01/2006 - "Rescue chemotherapy was administered but the patient died soon after with severe lactic acidosis" 06/01/2003 - "The authors describe a 7-year-old boy with ALL presenting with severe lactic acidosis and renal tubular dysfunction, both of which were refractory to conventional management and resolved rapidly with appropriate chemotherapy." 10/01/1994 - "Resolution of the lactic acidosis and bilateral renal enlargement occurred with initiation of chemotherapy and recurred with each subsequent relapse." Get all the results and reference details, order at left...
4.	Cardiopulmonary Resuscitation (CPR) 12/01/1987 - "Lactic acidosis during closed-chest CPR in dogs." 11/01/1985 - "The progression of acidemia was remarkably slow; arterial blood pH remained normal for more than 16 min. Even though there was significant lactic acidosis, concurrent respiratory alkalosis during CPR accounted for the greatly delayed onset of acidemia" 02/01/1993 - "Acid-base changes occurring during cardiac arrest and subsequent CPR are related to a complex low-perfusion state characterized clinically by venous and tissue hypercarbic and metabolic (lactic) acidosis" 11/01/1986 - "Accordingly, increased venous PCO2 rather than metabolic acidosis due to lactic acidosis predominates during the initial 8 min of cardiopulmonary resuscitation" 05/01/1989 - "Our results during CPR demonstrate a) a significant discrepancy between arterial and mixed venous blood gases but also a large and significant discrepancy between mixed venous and myocardial venous blood gases, b) significant anaerobic systemic and myocardial metabolism, and c) that mixed venous and myocardial venous acidosis is possibly a result of lactic acidosis." Get all the results and reference details, order at left...
5.	Combination Drug Therapy (Combination Chemotherapy) 01/01/1978 - "The third patient responded successfully to the early initiation of combination chemotherapy with achievement of a clinical remission and correction of the lactic acidosis" 12/01/1998 - "Fluid restriction improved SIADH, and combination chemotherapy for SCLC improved the lactic acidosis although the tumor size did not change." Get all the results and reference details, order at left...
61 Therapies and Procedures and 241 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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