|4.||Hypotension (Low Blood Pressure)
|1.||Wagner, Carsten A: 27 articles (05/2015 - 03/2002)|
|2.||Curthoys, Norman P: 17 articles (09/2014 - 01/2002)|
|3.||Mitch, William E: 15 articles (09/2014 - 01/2002)|
|4.||Xiong, Zhi-Gang: 15 articles (02/2012 - 07/2003)|
|5.||Weiner, I David: 13 articles (10/2015 - 02/2006)|
|6.||Kraut, Jeffrey A: 13 articles (06/2015 - 06/2005)|
|7.||McBride, B W: 13 articles (10/2012 - 12/2002)|
|8.||Bushinsky, David A: 13 articles (08/2012 - 10/2002)|
|9.||Handlogten, Mary E: 12 articles (10/2015 - 02/2006)|
|10.||Simon, Roger P: 12 articles (02/2011 - 07/2003)|
|1.||Lactic AcidFDA LinkGeneric
10/01/2000 - "Over the time scale of 24 hours, lactate derived from continuous dialysis circuits is efficiently cleared from the blood of most patients with multi-organ failure, but with less effect on systemic acidosis than is produced by equivalent amounts of bicarbonate."
06/01/1995 - "Response to daily training was most clearly reflected in altered lactate levels and heart rate; recovery improved with increased training which enhanced aerobic capacity and decreased metabolic acidosis."
10/01/2010 - "Comparing the two indicators of acidosis using method of "Gold standard" confirmed the higher sensitivity of lactate values above 6.7 mmol/l compared to pH < 7.00 in relation to very low values of Apgar at 5 minutes. "
01/01/2004 - "Thus, avoiding cerebral anaerobic metabolism and acidosis is beneficial to control lactate and H(+), but no compound inhibiting mediators/mediator channels showed beneficial results in conducted clinical trials, despite successful experimental studies. "
01/01/2011 - "Bicarbonate fluids led to a more rapid fall in lactate and greater improvement in base excess during CRRT, but not overall control of acidosis."
06/01/1988 - "Recent in vitro studies have suggested that the presence of extracellular acidosis is protective against the development of oxygen-deprivation injury in several tissues. "
06/01/1995 - "Adjunctive hyperbaric oxygen (HBO) is another treatment modality that appears to be promising; oxygen in sufficient concentrations is fungicidal and decreases acidosis thereby increasing tissue survival. "
11/01/2001 - "Portal venous blood flow and gut oxygen delivery were improved, but no concomitant reduction in endotoxin-induced intestinal mucosal acidosis was observed. "
08/01/1999 - "While both ET(A+B)ra and ET(MIX)ra improved gut oxygen delivery only the latter attenuated the profound endotoxin-induced ileal mucosal acidosis. "
12/11/1993 - "Treatment with a small volume of the solution increased cardiac output, improved oxygen carriage, corrected acidosis and stimulated renal function. "
|3.||Sodium Bicarbonate (Baking Soda)FDA LinkGeneric
05/01/2012 - "Sodium bicarbonate infusion was effective in correcting the strong ion acidosis. "
05/01/1998 - "The application of a calculated buffering of acidosis with sodium bicarbonate showed a good outcome in selected cases. "
02/01/2004 - "Therapeutic efficacy of the sodium bicarbonate administration was also evaluated in cases with hyperchloremic acidosis. "
05/01/1993 - "Recent recommendations suggest that sodium bicarbonate may not be useful for the treatment of metabolic acidosis. "
08/01/2010 - "We investigated the efficacy of 8.4% sodium bicarbonate as an alternative method of lowering ICP without generating a metabolic acidosis. "
|4.||Glucose (Dextrose)FDA LinkGeneric
08/01/2010 - "These data may help determine the plasma glucose levels most effective for avoiding brain metabolic acidosis in patients after SAH. "
03/01/2015 - "Addition of glucose improved ion balance but led to metabolic acidosis. "
07/15/2008 - "This is associated with an increase in glucose oxidation, a decrease in acidosis, and an improvement in cardiac function and efficiency during and following ischaemia. "
06/01/2002 - "However, data accumulated over the last 60 years in animal and in vitro studies have provided considerable evidence that the kidney plays an important role in glucose homeostasis in conditions other than acidosis and prolonged fasting. "
05/15/1998 - "This traditional perception is based on methodologically inadequate net balance studies, which other than after a prolonged fast or during metabolic acidosis showed no significant net renal glucose release. "
10/01/2008 - "In addition, acidosis or variations in extracellular calcium have no influence on potency/efficacy of WS-12 for TRPM8. "
07/01/2008 - "As far as it was monitored in the studies, the calcium concentration of the diet did not have a significant impact on the degree of acidosis induced by AS. "
10/01/2006 - "Since acidosis reduces calcium binding to serum protein and actually increases iCa, the association between base deficit and iCa in this study requires further investigation."
09/01/2006 - "The present investigation therefore aimed to study the effects of chronic metabolic acidosis induced by 1.5% NH(4)Cl administration on the three components of duodenal calcium transport, namely, solvent drag-induced, transcellular active, and passive paracellular components, in rats using an in vitro Ussing chamber technique. "
05/15/2006 - "In this paper, we review the experimental findings concerning the effects of acidosis on the action potential and calcium handling in the cardiac ventricular myocyte, and we present a modelling study that establishes the contribution of the different effects to altered Ca2+ transients during acidosis. "
11/01/1978 - "Control of elevated serum potassium levels did not normalize urinary acid excretion, but systemic acidosis was improved. "
01/01/2011 - "The obvious evidence of metabolic acidosis in response to high protein diet in the subjects with high potassium intake and intensive resistance exercise were not shown in this study results. "
12/01/2009 - "Various studies have suggested that potassium depletion leads to acidosis and hypocitraturia. "
05/01/1982 - "Free-flow micropuncture studies revealed that the rate of fluid delivery to the distal tubule was 45% greater during acidosis compared with control and that potassium secretion increased in both the distal and collecting tubule. "
01/01/1967 - "Separated studies of effects of hypovolaemia, acidosis, and potassium loss."
|7.||Adenosine Triphosphate (ATP)IBA
08/01/1991 - "The ATP levels of the PEP-treated rats were significantly higher than those of the control rats, and also intracellular acidosis was improved during post-ischemic reperfusion. "
06/01/1996 - "Effects of preconditioning were unrelated to cytosolic [ATP], but were associated with reduced ischemic acidosis, and improved post-ischemic recovery of [Mg2+], [P(i)] and delta GATP. "
11/15/2010 - "The present study was performed to investigate the effect of acidosis on the efflux of ATP from skeletal muscle. "
06/17/2009 - "From these results, it seems likely that a decrease in ATP below the threshold of rigor cross-bridge formation (approximately 0.4 mM estimated indirectly in the this study), rather than elevation of [Na+]i or intracellular acidosis, inhibits the Mg2+ efflux, suggesting the absolute necessity of ATP for the Na+/Mg2+ exchange."
02/01/1997 - "Studies of skinned fibers suggest that the rate of ATP turnover in skeletal muscle is depressed by acidosis. "
09/01/2014 - "Metabolic acidosis, abnormal chest X-ray, arrhythmias, and elevated serum creatinine levels are useful prognostic factors for predicting GlySH mortality. There is no antidote and the mainstay of treatment for systemic toxicity is decontamination and aggressive supportive therapy. "
01/01/2014 - "Exposure to LPS temporarily increased pulmonary artery mean pressure and impeded renal function with elevated serum creatinine and acidosis compared to a control group over the 30-hour study period. "
11/01/2015 - "Oxalate:creatinine clearance ratios indicated enhanced net re-absorption of oxalate by the kidney during a metabolic acidosis, but this was not associated with any substantive changes to serum oxalate levels. "
06/01/2013 - "On the third day of hospitalization, creatinine level increased to 8.81 mg/dl and metabolic acidosis developed. "
09/01/2011 - "Two patients presenting aggressive disease (N+ and pT3a) died of tumour progression after 20 and 14 months, respectively, while the other two are alive after 56 and 36 months of follow-up with no evidence of disease, stable serum creatinine (2.29 and 1.6 mg/dl) and mild metabolic acidosis. "
|9.||Insulin (Novolin)FDA Link
01/01/2005 - "To study were included randomly selected 37 patients with diabetes type 1, average age 15.5+/-2.25 years, with a duration of diabetes of more than 5 years (av 9.64+/-1.95 years), treated with intensive insulin therapy (MDI and CSII), without metabolic acidosis pH - 7.35. "
08/01/2015 - "Our results clearly indicate a pH dependent coupling among enzyme conformation, assembly and stability and suggest that cellular acidosis can have a large effect on IDE oligomerization state, inducing an enzyme inactivation and an altered insulin degradation that could have an impact on insulin signaling. "
01/01/2014 - "Management principles include aggressive volume replacement, initiation of intravenous insulin therapy, correction of acidosis, correction of electrolyte abnormalities and management of precipitating factors, as well as monitoring of maternal-fetal response to treatment. "
01/01/2013 - "The HTG gradually resolved following intravenous fluids and insulin infusion with slower correction of the metabolic acidosis. "
07/01/2012 - "Fluid repletion and insulin administration are mainstays of DKA treatment and serve to restore normal hemodynamic status while decreasing the metabolic acidosis. "
|10.||Tromethamine (Trometamol)FDA Link
03/01/1997 - "THAM uncompletely buffered acidosis but significantly improved contractility and relaxation. "
01/01/1977 - "Compared with 0.9 percent NaCl, both THAM and NaHCO3 were equally effective in correcting metabolic acidosis (p less than 0.05). "
12/10/1982 - "Substituting TRIS buffer for bicarbonate in the infusion also eliminated acidosis, but neither concentrations of 1 M or 5 M buffer prevented the stomachs from ulceration (6 out of 6 with 1 M buffer and 5 out of 6 with 5 M buffer). "
11/01/1963 - "[THERAPEUTIC TRIAL OF A NEW BUFFER AGENT (THAM) IN METABOLIC ACIDOSIS OF RENAL ORIGIN]."
11/01/2013 - "The effect of acidosis was investigated by metabolically buffering the hypercapnic acidosis with tromethamine. "
02/01/1995 - "Although hypotensive resuscitation resulted in improved outcome, it was associated with significant acidosis. "
04/01/2014 - "Larger studies are needed to define the patient population most likely to benefit from aggressive resuscitation efforts during severe acidosis."
11/01/1969 - "[Basic study of resuscitation of the heart, with special reference to the effects of respiratory and metabolic acidosis on fine structures of the heart muscle]."
01/01/2015 - "During the resuscitation course, increased exposure to acidosis was associated with a higher complication rate. "
12/01/2013 - "Agents were tested at baseline and then with severe metabolic acidosis after 6 hours of resuscitation. "
|2.||Renal Dialysis (Hemodialysis)
04/01/2004 - "Early diagnosis and rapid correction of the metabolic acidosis using hemodialysis provides the possibility of a positive outcome even in severe cases. "
03/01/1999 - "Immediately after beginning ACA therapy, she developed a severe anion gap metabolic acidosis that briefly improved after hemodialysis. "
05/01/2010 - "This commentary reviews the principles of acid-base homeostasis in patients receiving intermittent hemodialysis and the studies that have addressed the adverse effects of metabolic acidosis in this patient population. "
12/01/2006 - "The objective of this study is to analyze the role of hemodialysis in acidosis correction in intensive care unit patients, with an emphasis on chloride levels in plasma and dialysate. "
06/01/2005 - "Interventional studies for metabolic acidosis have yielded inconsistent results in CRF and maintenance hemodialysis patients. "
|3.||Continuous Ambulatory Peritoneal Dialysis (CAPD)
05/01/1996 - "These results demonstrate that optimal correction of acidosis in CAPD is beneficial in terms of protein turnover."
01/01/1995 - "These results suggest that the optimized formulation is effective in improving nutritional parameters in CAPD patients while avoiding unwanted side-effects such as acidosis."
01/01/1993 - "A CAPD bicarbonate solution is effective in uremic acidosis correction, does not affect dialysis adequacy, is safe, and well tolerated."
10/01/1997 - "The aim of this study was to assess the possible benefits, in the nutritional state and morbidity, of improved correction of acidosis in the first year of treatment with continuous ambulatory peritoneal dialysis (CAPD). "
01/01/2005 - "Our study suggested that CAPD patients with better RRF were more susceptible to metabolic acidosis, which was characterized by normal anion gap and hyperchloremia. "
|4.||Artificial Respiration (Mechanical Ventilation)
01/01/2013 - "The aim of our study was to evaluate the effects of moderate and prolonged (72 hours of mechanical ventilation) hypercapnic acidosis on in vivo diaphragmatic function. "
04/01/1996 - "Side effects of NMV seem less severe than those induced by invasive MV. In conclusion in selected patients a trial of noninvasive mechanical ventilation, as an adjunct to medical therapy, should be instituted at an early stage of ARF episodes before severe acidosis ensures, to avoid ET intubation."
07/01/1995 - "Success with non-invasive mechanical ventilation was associated with less severely abnormal baseline clinical and functional parameters, and with less severe levels of acidosis assessed during an initial trial of non-invasive mechanical ventilation. "
11/01/2015 - "Criteria for clinical decompensation after IABP insertion and before LVAD included the need for more advanced temporary support, initiation of mechanical ventilation or dialysis, increase in vasopressors/inotropes, refractory ventricular arrhythmias, or worsening acidosis. "
10/01/2014 - "Being an ICU patient and requiring mechanical ventilation significantly increased the risk of lactic acidaemia or acidosis (OR=22.75, 95% CI 4.24-122.09; OR=32.67, 95% CI 5.83-183.19, respectively; P<0.001). "
|5.||Cardiopulmonary Resuscitation (CPR)
07/01/1984 - "Our results also suggest that the adequate treatment of metabolic acidosis, and improved ventilatory management with improved PO2 and optimization of PCO2, play a role in the better outcome of cardiopulmonary resuscitation."
03/01/2014 - "Metabolic acidosis and hyperlactatemia were evident in all samples in the study while an increased PvCO2 occurred in 88% of samples collected during CPR and in 61% of samples collected following ROSC. "
04/01/1990 - "These studies demonstrate marked but reversible acidosis predominantly as the result of myocardial CO2 production during CPR."
07/01/2014 - "More infants in the basal ganglia vs hippocampal group required delivery room cardiopulmonary resuscitation (P = 0.05), exhibited persistent severe acidosis, severe amplitude electroencephalography suppression, and encephalopathy at birth (P < 0.05). "
09/14/2010 - "CPR duration was not associated with mortality, whereas patients with metabolic acidosis and noncardiac structural or chromosomal anomalies had higher mortality."