|1.||Duodenal Ulcer (Curling's Ulcer)
|3.||Peptic Ulcer (Peptic Ulcers)
|1.||Varro, Andrea: 5 articles (01/2015 - 11/2007)|
|2.||Iijima, Katsunori: 4 articles (07/2015 - 11/2010)|
|3.||Koike, Tomoyuki: 4 articles (07/2015 - 11/2010)|
|4.||Shimosegawa, Tooru: 4 articles (07/2015 - 11/2010)|
|5.||Pritchard, D Mark: 4 articles (01/2015 - 01/2009)|
|6.||Ware, Joseph A: 4 articles (11/2014 - 11/2013)|
|7.||Zavros, Yana: 4 articles (12/2010 - 01/2002)|
|8.||Merchant, Juanita L: 4 articles (12/2010 - 01/2002)|
|9.||Samuelson, Linda C: 4 articles (03/2007 - 01/2002)|
|10.||Hammond, Charles E: 3 articles (08/2015 - 04/2007)|
|1.||Dipyridamole (Persantine)FDA LinkGeneric
09/15/2012 - "Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria."
04/15/2012 - "Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria."
01/01/2013 - "The aim of this study was to develop new dipyridamole (DP) salts with pH-independent solubility for improving oral bioavailability under hypochlorhydria. "
06/01/1987 - "2. Since low gastric acid secretion is a stimulus for gastrin release in mature animals the present study examined whether the relative hypochlorhydria in the sheep fetus was sustaining the hypergastrinaemia. "
01/01/2013 - "Failure of netazepide to increase serum gastrin further is consistent with achlorhydria. "
11/01/2010 - "Gastrin-stimulated acid output was assessed by endoscopic gastrin test and hypochlorhydria was defined as 0.6 mEq/10 min or lower. "
07/01/2007 - "Furthermore, vtg-2J/vtg-2J mice showed gastric achlorhydria associated with elevation of their serum gastrin levels. "
07/01/2006 - "Independently of gastrin, achlorhydria is associated with gastric bacterial overgrowth and intestinal gene expression patterns and is associated with predisposition to disease. "
|3.||Cimetidine (Biomet)FDA LinkGeneric
02/01/2003 - "These numbers show a trend suggesting that cimetidine-induced hypochlorhydria increases shedding of viable H. "
02/01/2003 - "Five of the 16 patients gave positive cultures with at least one stool from both normal pH and cimetidine-induced hypochlorhydria. "
02/01/2003 - "Helicobacter pylori in cathartic stools of subjects with and without cimetidine-induced hypochlorhydria."
03/01/1985 - "Only when the dose of cimetidine infusion was doubled to 100 mg/h and administered with a constant infusion of antacid was sustained achlorhydria achieved in each patient."
08/01/1981 - "Cimetidine-induced hypochlorhydria allows bacterial proliferation in the stomach; 75 per cent of aspirates from 44 fasting patients taking cimetidine 1 g daily were found to contain bacteria 2--4 h after the last dose. "
|4.||Pepsinogen A (Pepsinogen)IBA
01/01/2014 - "After checking the correlation between gastric acid secretion and serum pepsinogen, the receiver operating characteristics analyses were employed for determining the most suitable cutoff points of serum pepsinogen for the gastric acid secretion status (i.e., hypochlorhydria, profound hypochlorhydria, and hyperchlorhydria). "
01/01/1991 - "In relatives with achlorhydria and low serum pepsinogen I levels the incidence of malignancy did not significantly differ from that in controls of similar age and sex distribution. "
09/06/1957 - "Uropepsinogen excretion in patients with pernicious anaemia and in subjects with simple achlorhydria."
09/01/1994 - "The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that is, patients with achlorhydria--and 22 with healed duodenal ulcer and normal chlorhydria were studied. "
11/01/1989 - "These results show that achlorhydria is frequently associated with hypergastrinemia and low pepsinogen I serum levels in patients with cirrhosis and gastric vascular ectasias and suggest that this disturbance is not secondary to a morphologic abnormality of the gastric mucosa."
|5.||Hydrochloric Acid (Hydrogen Chloride)FDA Link
12/01/1992 - "In reduced or absent stomach acid secretion a constellation of gastrointestinal symptoms has been consistently observed and reported by clinicians in the past, and treatment of the hypochlorhydria with hydrochloric acid or its substitutes has often been observed to be effective in reducing these symptoms."
07/01/2014 - "Hypochlorhydria refers to suppression of hydrochloric acid secretion by the stomach. "
08/01/1991 - "In achlorhydria is can be used for determination of a residual capacity of the stomach to secrete the hydrochloric acid in failure of humoral stimulators."
04/02/1979 - "[Hydrochloric acid treatment of achlorhydria]."
01/01/1973 - "Gastric emptying in patients with achlorhydria or hyposecretion of hydrochloric acid."
05/01/1988 - "Secretin test and achlorhydria."
04/01/1988 - "False-positive secretin-KABI provocation test associated with achlorhydria."
07/01/1987 - "Thus, the intravenous secretin test may be positive in patients with achlorhydria-related hypergastrinemia. "
07/01/1987 - "Positive intravenous secretin test in patients with achlorhydria-related hypergastrinemia."
08/01/1986 - "Diagnosis of achlorhydria by plasma secretin determination--a tubeless approach."
|7.||Anti-Bacterial Agents (Antibiotics)IBA
04/01/1997 - "pylori and extreme hypochlorhydria has a deleterious effect on the organism, the most likely mechanism by which antisecretory drugs as a class provide this effect is by improving the efficacy of the antibiotics themselves. "
10/01/2001 - "Significant risk factors for HUS were age <15 years or >65 years (odds ratio [OR], 4.4; 95% confidence interval [CI], 1.3-14.4), hypochlorhydria (OR, 6.7; 95% CI, 1.9-24.0), and coincidental antibiotics (OR, 4.7; 95% CI 1.4-16.5). "
11/10/1998 - "Some special risk groups for which the risks could be quantified are (1) persons with underlying diseases, such as neoplasms or diabetes mellitus (1200 cases/100,000 pyar); (2) persons with achlorhydria or who excessively use antacids (1100 cases/100,000 pyar); (3) persons who have recently been treated with antibiotics that disturb the normal gut flora (1700 cases/100,000 pyar); (4) nurses (900 cases/100,000 pyar); (5) caterers (900 cases/100,000 pyar); (6) slaughterline personnel (1800 cases/100,000 pyar). "
01/01/2002 - "When omeprazole-treated mice were treated with antibiotics alone, elevated plasma gastrin levels returned to baseline and D cell numbers returned to resting levels despite persistent hypochlorhydria. "
|8.||Interleukin-1beta (Interleukin 1 beta)IBA
05/01/2007 - "IL-1 beta is a potent proinflammatory cytokine which causes a partial clearance of the organism as well as hypochlorhydria. "
09/01/2005 - "Interleukin-1beta (IL-1beta) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylori infection. "
07/01/2002 - "Interleukin 1beta polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan."
|10.||Proton Pumps (Proton Pump)IBA
06/01/2013 - "This study aimed to investigate the effects of a combination of a dairy product fermented by lactobacilli (DFL) and galactooligosaccharides (GOS) on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor (PPI). "
12/05/2011 - "This study showed that exposures from F2 were not meaningfully different in the presence of proton pump inhibitor (PPI) as compared to non-PPI, thus confirming that the F2 formulation was successful in overcoming the achlorhydria effect. "
11/01/2011 - "The purpose of the present study is to investigate the effects of hypochlorhydria induced by proton pump inhibitor (PPI) administration and intake of a dairy product fermented by lactobacilli (DFL) on bone metabolism in growing rats. "
11/01/2013 - "In this patient, we believe proton pump inhibitor (PPI) use caused hypochlorhydria and coexistence H. "
06/01/2013 - "A combination of a dairy product fermented by lactobacilli and galactooligosaccharides shows additive effects on mineral balances in growing rats with hypochlorhydria induced by a proton pump inhibitor."
07/01/1991 - "A controlled randomized study and a subsequent prospective therapeutic trial have demonstrated the efficacy of an intensive therapy comprising hourly intravenous injections of 100 mg of cimetidine along with a continuous nasogastric infusion of a liquid antacid at the rate of 0.5 ml per minute in achieving achlorhydria and controlling bleeding in patients with bleeding peptic ulcer. "
03/01/1994 - "Patients with achlorhydria, hypertrophic gastropathy, or after total gastrectomy fell into an aberrant category. "
10/01/1957 - "[Factors responsible for achlorhydria after subtotal gastrectomy]."
08/01/1957 - "[Factors responsible for achlorhydria after subtotal gastrectomy]."
07/01/1957 - "[Factors responsible for achlorhydria after subtotal gastrectomy]."
01/01/1951 - "[Post-gastrectomy achlorhydria]."
|3.||Proximal Gastric Vagotomy
10/01/1975 - "Ulcus duodenum and ulcus pepticum jejuni post-operativum are the domain of vagotomy, whereas in ulcus ventriculi in most cases is resected according to Billroth I. In old patients or severe concomitant diseases vagotomies--even in hypochlorhydria--yield as satisfying results as excision of ulcer and segment resections. "
05/01/1992 - "In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlohydria: anti-acid treatment, vagotomy... "
01/01/1975 - "Hypergastrinaemia associated with hypo-achlorhydria occurs in atrophic gastritis without extensive antral lesion and after vagotomy. "
01/01/1993 - "In our patients with pernicious anemia, as a result of hypo or achlorhydria, serum gastrin increase was higher than in any other cause of hypochlorhydria: anti-acid treatment, vagotomy ... "
02/01/1989 - "Basal serum gastrin (mean +/- SEM) was progressively higher for each group; normal (42 +/- 3 pg/ml), duodenal ulcer (53 +/- 4 pg/ml), vagotomy (226 +/- 54 pg/ml), hypochlorhydria (346 +/- 92 pg/ml), achlorhydria (844 +/- 100 pg/ml). "
12/07/1979 - "33 transplant candidates of groups I (hypochlorhydria, no ulcer) and II (normochlorhydria, no ulcer) were treated by medical prophylaxis alone. "
08/01/1963 - "ZOLLINGER-ELLISON SYNDROME: SURGICAL REMOVAL OF PARIETAL CELL MASS WITH PRESERVATION OF ANTRUM AND PYLORUS, ILEOCOLONIC TRANSPLANT AND RESULTANT ACHLORHYDRIA."