Acetyl-CoA Hydrolase

An enzyme that catalyzes reversibly the hydrolysis of acetyl-CoA to yield CoA and acetate. The enzyme is involved in the oxidation of fatty acids. EC 3.1.2.1.

Also Known As:

Acetyl CoA Acylase; Acetyl CoA Deacylase; Acetyl CoA Hydrolase; Acylase, Acetyl-CoA; Deacylase, Acetyl-CoA; Hydrolase, Acetyl-CoA; Acetyl Coenzyme A Hydrolase; Acetyl-CoA Acylase; Acetyl-CoA Deacylase; Acetyl-CoA hydrolase

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Thiolester Hydrolases
        Acetyl-CoA Hydrolase: 4
        C elegans ACER-1 protein
        human ACOT12 protein
        mouse Acot12 protein

Related Diseases

1.	Starvation 08/01/1974 - "Hepatic acetyl-CoA hydrolase activity is increased by starvation in rats and sheep and during the suckling period in young rats. " 10/15/1985 - "Significant increase in the activity of an acetyl-CoA hydrolase (ATP-stimulated, ADP-inhibited enzyme) in the supernatant fraction of rat liver was observed after 44-68 h of starvation (about 2-fold), and in the early stage of diabetes (about 1.6-fold), but not in the chronic stage of diabetes. "
2.	Hymenolepiasis 01/01/1991 - "[The activity of acetyl COA hydrolase (AACo) and aminotransferases AspAT and AlAt in the course of experimental hymenolepiasis]."
3.	Body Weight (Weight, Body) 03/16/1995 - "Rats treated with sulfur-substituted fatty acids, i.e., 3-thiadicarboxylic acid (400 mg/day per kg body weight), showed a significant increase in acetyl-CoA hydrolase activity where the peroxisomal and cytosolic hydrolases were increased 3.9- and 2.7-fold, respectively, compared to palmitic acid treated rats. "

Related Drugs and Biologics

1.	Palmitic Acid (Hexadecanoic Acid)
2.	Sulfur
3.	Hydrolases
4.	Fatty Acids (Saturated Fatty Acids)
5.	Enzymes
6.	Transaminases (Aminotransferases)
7.	Adenosine Triphosphate (ATP)
8.	Adenosine Diphosphate (ADP)
9.	1,10-bis(carboxymethylthiodecane)