Acetazolamide (Diamox)
One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Also Known As:
Diamox; Acetadiazol; Acetazolam; Acetazolamide Sodium, (Sterile); Acetazolamide, Monosodium Salt; Ak-Zol; Apo-Acetazolamide; Diacarb; Diuramide; Défiltran; Edemox; Glauconox; Glaupax; Huma-Zolamide; Ak Zol; AkZol; Apo Acetazolamide; ApoAcetazolamide; Huma Zolamide; HumaZolamide; Acetamide, N-(5-(aminosulfonyl)-1,3,4-thiadiazol-2-yl)-
Networked: 2665
relevant articles (249 outcomes,
339 trials/studies)
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Drug Context: Research Results
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Related Diseases
1. | Altitude Sickness (Mountain Sickness)
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2. | Pseudotumor Cerebri (Idiopathic Intracranial Hypertension)
03/01/2018
- " And, although the treatment tools have not changed in several years, important evidence for efficacy for acetazolamide finally came to light in recent years in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). " 02/01/2011
- " In the future, results from the ongoing multicenter, double-blind, placebo-controlled Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) will provide important data regarding the efficacy of acetazolamide and the utility of diet and exercise." 03/01/2016
- " The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) showed that acetazolamide provided a modest, significant improvement in mean deviation (MD). " 02/13/2018
- " The Idiopathic Intracranial Hypertension Treatment Trial found improvement in visual fields, optical coherence tomography, Frisen grade, and quality of life with acetazolamide compared to placebo in adult patients, and these findings have been translated to the pediatric population. " 01/01/2024
- " Despite its use as the first-line treatment, data on acetazolamide's effectiveness and safety in pediatric idiopathic intracranial hypertension is sparse. "
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3. | Headache (Headaches)
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4. | Papilledema
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5. | Hypoxia (Hypoxemia)
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