|1.||Marchal, Juan A: 4 articles (09/2011 - 01/2005)|
|2.||Gallo, Miguel A: 3 articles (09/2011 - 02/2005)|
|3.||Aránega, Antonia: 3 articles (09/2011 - 01/2005)|
|4.||Espinosa, Antonio: 3 articles (12/2007 - 01/2005)|
|5.||Rodríguez-Serrano, Fernando: 2 articles (09/2011 - 12/2007)|
|6.||Caba, Octavio: 2 articles (09/2011 - 12/2007)|
|7.||Campos, Joaquín M: 2 articles (09/2011 - 12/2007)|
|8.||Boulaiz, Houria: 2 articles (09/2011 - 01/2005)|
|9.||Aiello, Stefania: 2 articles (02/2005 - 01/2005)|
|10.||Campos, Joaquín: 2 articles (02/2005 - 01/2005)|
|1.||Autistic Disorder (Autism)
10/01/2004 - "By comparison, the 18:1n-9 and 20:4n-6 values were significantly lower in patients with regressive autism compared to controls while 22:5n-3, total n-3 and total dimethyl acetals were significantly lower in both regressive autism and ASP groups compared to controls. "
04/01/2009 - "These results are consistent with the only other study to measure dimethyl acetals in children with autism, and suggest that the function of peroxisomes and the enzymes of the peroxisome involved with fatty acid metabolism may be affected in autism."
05/29/2003 - "Accordingly, the acyclic acetals 6-8 may be efficient prodrugs of ECyd, that are effectively reduced under physiological conditions releasing ECyd in acidic tumor tissues."
12/01/2000 - "From a classic approach in cancer chemotherapy towards differentiation therapy: acyclic and cyclic seven-membered 5-fluorouracil O,N-acetals."
01/01/1978 - "Following the lead given by Albert Szent-Györgyi's bioelectronic theory of cancer, work was continued in two major directions: (i) designing new electrophilic molecules, related to methylglyoxal, and (ii) using L-ascorbic acid as a (non-toxic) carrier for methylglyoxal and its derivatives in the form of its acetals. "
05/11/2014 - "Dextran modified with pendant acetals is used to load doxorubicin (DOX) and a near-infrared-emissive conjugated polymer (BTTPF), and this aims to provide selective drug release at therapeutic targets including tumors. "
03/01/1980 - "Fourteen phosphorylated acetals and aldehydes were synthesized for testing in vitro as inhibitors or substrates of aldehyde oxidase, an enzyme involved in the conversion of aldophosphamide to inactive carboxyphosphamide, and for concurrent in vivo administration with cyclophosphamide to mice bearing L1210 ascites tumor cells. "
|3.||Breast Neoplasms (Breast Cancer)
02/01/2005 - "We prepared a series of bioisosteric benzannelated seven-membered 5-FU O,N-acetals to test them against the MCF-7 human breast cancer cell line. "
12/01/2007 - "Antiproliferative activity, cell-cycle dysregulation, and cellular differentiation: salicyl- and catechol-derived acyclic 5-fluorouracil O,N-acetals against breast cancer cells."
01/01/2005 - "Taking 1-[(2-oxepanyl)]-5-fluorouracil previously prepared by us, we committed ourselves to increase the lipophilicity of this upper cyclohomologue of Ftorafur and prepared a series of bioisosteric benzannelated seven-membered 5-FU O,N-acetals to test them against the MCF-7 human breast cancer cell line. "
|4.||Dehydration (Water Stress)
02/19/2010 - "It has been widely accepted that both the protection of carbonyls and the deprotection of acetals and ketals involve the participation of a water molecule: formation of acetals and ketals is a dehydration process, whereas the deprotection is often referred to as hydrolysis, which, as implied by its name, always requires the presence of water. "
01/05/2007 - "A highly efficient BF3.OEt2-catalyzed formal dehydration C-C coupling reaction between readily available alpha-EWG ketene-(S,S)-acetals and various alcohols via direct substitution of the hydroxy group in alcohols has been developed. "
|1.||Drug Therapy (Chemotherapy)