|1.||Salaspuro, Mikko: 18 articles (06/2015 - 01/2002)|
|2.||Yokoyama, Akira: 13 articles (01/2010 - 03/2003)|
|3.||Seitz, Helmut K: 11 articles (01/2015 - 07/2005)|
|4.||Ren, Jun: 11 articles (01/2014 - 03/2002)|
|5.||Salaspuro, M: 10 articles (08/2013 - 04/2000)|
|6.||Yokoyama, Tetsuji: 9 articles (01/2010 - 09/2003)|
|7.||Szmitkowski, Maciej: 8 articles (06/2015 - 11/2003)|
|8.||Tuma, Dean J: 8 articles (03/2015 - 02/2002)|
|9.||Thiele, Geoffrey M: 8 articles (03/2015 - 02/2002)|
|10.||Smith, David: 8 articles (03/2013 - 01/2003)|
|1.||Alcoholism (Alcohol Abuse)
01/01/2008 - "These subjects display high levels of blood acetaldehyde when consuming alcohol, a condition that exerts a 66 to 99% protection against alcohol abuse and alcoholism. "
06/01/2014 - "To our knowledge, this is the first report to demonstrate the association of ADH1B*2 allele with blood EtOH and acetaldehyde levels in humans, and these results suggest that higher blood EtOH and acetaldehyde concentrations in ADH1B*2/*2 may constitute the mechanism of protection against alcoholism by ADH1B*2/*2."
08/01/2009 - "The partial protection against alcoholism has been ascribed to the faster elimination of acetaldehyde by residual hepatic ALDH2 activity and the lower accumulation in circulation in nonalcoholic heterozygotes. "
10/01/2007 - "In spite of the well documented psychoactivity of acetaldehyde, the precise role of this compound in alcohol abuse remains a matter of intense debate among scientists devoted to the study of alcoholism. "
07/01/2006 - "Future studies are needed to assess alcohol outcome expectancies at different phases of alcohol dependence and to evaluate the concurrent relationships of blood levels of acetaldehyde with physiological and psychological outcomes among persons with alcoholism who have different ALDH genotypes."
09/01/1991 - "This study is the first to report the occurrence of facial flushing and raised blood acetaldehyde concentration among Japanese alcoholics."
01/01/1986 - "Questionnaire study of Japanese volunteers indicated that ALDH-I deficient individuals showed flushing, palpitation and other uncomfortable somatic signs, due to reduced metabolism of acetaldehyde, much more frequently than ALDH-I positive ones. "
04/01/2015 - "Acetaldehyde produces the vasodilatation in the "Asian flushing syndrome". "
01/01/2015 - "The Glu504Lys single nucleotide polymorphism (SNP) of ALDH2 gene, which is found in approximately 40% of the East Asian populations, causes defect in the enzyme activity of ALDH2, leading to alterations in acetaldehyde metabolism and alcohol-induced "flushing" syndrome. "
12/01/2014 - "Findings indicate that ALDH2*2, rather than ADH1B2*2, is a causal variant allele for the accumulation of blood acetaldehyde and the resultant facial flushing during low alcohol consumption."
03/01/2008 - "The role of acetaldehyde in mediating effects of alcohol on expression of endogenous opioid system genes in a neuroblastoma cell line."
08/28/2006 - "In this study, we investigated the protective effects of adiponectin on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. "
02/03/2006 - "In this study, we investigated the protective effects of rosiglitazone on acetaldehyde-induced apoptosis in human neuroblastoma SH-SY5Y cells and attempted to examine its mechanism. "
03/01/2011 - "We recently reported that ethanol and acetaldehyde, the first product of ethanol metabolism, affect transcription of opioid system genes in human SH-SY5Y neuroblastoma cells. "
08/28/2006 - "Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity."
01/01/2010 - "Direct administration of acetate increased nociceptive behaviors suggesting that acetate, not acetaldehyde, accumulation results in hangover-like hypersensitivity in our model. "
12/01/2006 - "However possible allergic reaction to acetaldehyde could not be excluded."
10/01/2004 - "When retesting 9 of these 18 patients only an allergic reaction to acetaldehyde was confirmed. "
01/01/1999 - "These results indicate that acetaldehyde may contribute to the development of various hypersensitivity reactions by directly increasing histamine release from mast cells."
10/01/1992 - "Hypersensitivity to acetaldehyde-protein adducts."
|5.||Esophageal Neoplasms (Esophageal Cancer)
05/01/2011 - "Literature studies discussed suggest an additional role of the acetaldehyde burst on the paradoxical (hormesis) protection of the ADH1B*2 polymorphism against esophageal cancers in alcoholics."
01/01/2006 - "In this study, this process is further characterized and the effect of acetaldehyde examined to elucidate the possible mechanisms behind the epidemiological evidence that the incidence of esophageal cancer is higher in alcoholics. "
07/01/2005 - "In conclusion, the present study revealed a significant gene-environment interaction between alcohol drinking and the ALDH2 polymorphism regarding esophageal cancer risk among a general population in Japan, providing concrete evidence of a role for acetaldehyde in neoplastic development. "
01/01/2015 - "Thus, IARC recently categorized alcohol-drinking-related acetaldehyde to Group 1 for head and neck and esophageal cancers. "
01/01/2013 - "Our hypothesis is that alcohol and acetaldehyde are produced during the fermentation process and that their carcinogenic potential contributes to the high incidence of esophageal cancer. "
|1.||Ethanol (Ethyl Alcohol)
|3.||Alcohol Dehydrogenase (Alcohol Dehydrogenase (NAD+))
|5.||Biological Markers (Surrogate Marker)
|8.||acetaldehyde dehydrogenase (aldehyde dehydrogenase (NAD(P)+))