Peroxisomal Biogenesis Factor 2

A multi-pass transmembrane protein that contains a C-terminal RING finger domain. It localizes to the PEROXISOME membrane and is essential for peroxisome biogenesis. Mutations in the PEX2 gene are associated with ZELLWEGER SYNDROME and INFANTILE REFSUM DISEASE.

Also Known As:

PMP35; Peroxin-2; Peroxisomal Membrane Protein 35; Peroxisome Assembly Factor-1; Peroxisome Biogenesis Factor 2; Peroxin 2; Peroxisome Assembly Factor 1

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Peroxins: 50
      - Peroxisomal Biogenesis Factor 2: 4
        human PEX2 protein
        mouse PEX2 protein
        rat Pex2 protein
  - Membrane Proteins: 10078
    - Peroxisomal Biogenesis Factor 2: 4

Related Diseases

1.	Zellweger Syndrome (Zellweger's Syndrome) 01/01/1998 - "A novel mutation, R125X in peroxisome assembly factor-1 responsible for Zellweger syndrome." 03/01/1994 - "Assignment of the human peroxisome assembly factor-1 gene (PXMP3) responsible for Zellweger syndrome to chromosome 8q21.1 by fluorescence in situ hybridization." 03/01/1997 - "1. A human peroxisome assembly factor-1 (PAF-1) complementary DNA has been cloned that restores the morphological and biochemical abnormalities (including defective peroxisome assembly) in fibroblasts from a patient with group F Zellweger syndrome. "
2.	Cardiomegaly (Heart Hypertrophy) 09/01/1999 - "Interestingly, PAF-1 (peroxisome assembly factor-1), a C(3)HC(4)-type ZFP (RING domain-containing ZFP) showing a downregulated expression pattern in normal tissues was found to be upregulated in hypertrophic adult heart, suggesting a possible role for this fetal gene in the pathogenesis of cardiac hypertrophy. "

Related Drugs and Biologics

1.	Complementary DNA (cDNA)