Septic Abortion

Any type of abortion, induced or spontaneous, that is associated with infection of the UTERUS and its appendages. It is characterized by FEVER, uterine tenderness, and foul discharge.

Also Known As:

Networked: 168 relevant articles (9 outcomes, 6 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Abscess
2.	Uterine Perforation
3.	Infections
4.	Disseminated Intravascular Coagulation
5.	Abruptio Placentae (Placental Abruption)

Experts

1.	Jim, Belinda: 2 articles (12/2019 - 03/2018)
2.	Savaris, Ricardo F: 2 articles (11/2013 - 04/2011)
3.	Aisemberg, J: 2 articles (06/2009 - 05/2007)
4.	Billi, S: 2 articles (06/2009 - 05/2007)
5.	Franchi, A M: 2 articles (06/2009 - 05/2007)
6.	Ribeiro, M L: 2 articles (06/2009 - 05/2007)
7.	Gurung, Geeta: 2 articles (04/2009 - 02/2004)
8.	Pradhan, Neelam: 2 articles (04/2009 - 02/2004)
9.	Rana, Ashma: 2 articles (04/2009 - 02/2004)
10.	Kessel, E: 2 articles (12/2003 - 10/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Septic Abortion:

1.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/1977 - "Aggressive management that included early uterine evacuation and broad-spectrum antibiotics effective against both aerobic and anaerobic bacteria was the key to reduced morbidity and mortality rates in treatment of septic abortion. " 04/01/2011 - "We sought to investigate whether oral antibiotics are necessary, after 48 hours of clinical improvement, in uncomplicated septic abortion. " 04/01/2011 - "Are antibiotics necessary after 48 hours of improvement in infected/septic abortions? " 09/01/2023 - "Septic abortion requires prompt procedural management, intravenous antibiotics, and intravenous fluids. " 01/01/2021 - "Here, we identify an uncommon pathogen associated with septic abortion and highlight the importance of broad empiric and subsequent culture-guided antibiotic choice to ensure coverage."
2.	Amikacin (A.M.K)FDA LinkGeneric 11/01/1976 - "Amikacin for treatment of septic abortions: summary." 01/01/1976 - "Efficacy of amikacin in septic abortion: serum and urine antibiotic concentrations." 01/01/1976 - "Amikacin, 500 mg intramuscularly every twelve hours, was used concomitantly with uterine curettage and fluid and electrolyte restoration in thirty septic abortion patients. "
3.	Cefoxitin (Cefoxitin Sodium)FDA LinkGeneric 03/01/1986 - "It appears that cefoxitin was successful as a single agent in the treatment of septic abortion. " 03/01/1986 - "Cefoxitin: single agent treatment of septic abortion." 03/01/1986 - "An uncontrolled clinical trail was carried out to assess the efficacy of cefoxitin as the sole antimicrobial agent in the treatment of 22 cases of septic abortion in Lagos, Nigeria. " 03/01/1986 - " These findings suggest that cefoxitin can be used as a single antimicrobial agent in the treatment of septic abortion and may offer advantages over the use of a combination of antimicrobials." 03/01/1986 - "Using strict diagnostic criteria, a clinical trial of cefoxitin as the only antimicrobial agent in the treatment of twenty-five cases of septic abortion was carried out. "
4.	Anti-Infective Agents (Microbicides)IBA 03/01/1986 - "An uncontrolled clinical trail was carried out to assess the efficacy of cefoxitin as the sole antimicrobial agent in the treatment of 22 cases of septic abortion in Lagos, Nigeria. " 03/01/1986 - " These findings suggest that cefoxitin can be used as a single antimicrobial agent in the treatment of septic abortion and may offer advantages over the use of a combination of antimicrobials." 03/01/1986 - "Using strict diagnostic criteria, a clinical trial of cefoxitin as the only antimicrobial agent in the treatment of twenty-five cases of septic abortion was carried out. "
5.	LipopolysaccharidesIBA 01/01/2010 - "Maternal infections are a cause of abort in humans, but the mechanisms are not clear, so we have developed a murine model to study the mechanism of septic abortion by inducing embryonic resorption (ER) with lipopolysaccharide (LPS). "
6.	Fibrinogen (Factor I)FDA Link 10/01/1992 - "We present a study of fibrinogen levels in 133 patients who were prone to develop disseminated intravascular coagulation as a result of an underlying complication of pregnancy such as abruptio placentae, pregnancy-induced hypertension, missed abortion, septic abortion, intrauterine fetal death, vesicular mole and amniotic fluid embolism. "
7.	Heparin (Liquaemin)FDA LinkGeneric 01/01/1980 - "While in obstetrics heparin treatment of coagulopathy, generally, has been abandoned-prophylactic use of heparin has worked well, particularly in cases of septic abortion. " 01/01/1980 - "[Use of heparin in cases of septic abortion (author's transl)]." 01/01/1978 - "The generally accepted value of prophylactic medication of heparin in cases of septic abortion is not diminished by these casuistic observations. " 01/01/1978 - "Report on 62 cases of septic abortion with prophylactic use of heparin. " 01/01/1978 - "[Experiences with the preventive use of heparin in septic abortion]."
8.	Dacarbazine (DIC)FDA LinkGeneric 12/01/2001 - "This scenario of coagulation activation probably describes the principal events underlying emerging acute DIC states under pathophysiological conditions such as abruptio placentae, septic abortion, amniotic fluid embolization, and pregnancy toxemia. " 10/01/2001 - "Nevertheless, severe complications are possible in the case of septic abortion, including septicaemia, septic shock, DIC, renal insufficiency. " 02/01/2008 - "Clinical spectrum of pregnancy related ARF showed APH in 6 (14%) cases, PPH in 9 (24%) cases, septic abortion and puerperal sepsis and DIC in 13 (31%) cases, IUD in 6 (14%) and preeclampsia / eclampsia in 5 (12%) cases. " 02/01/1995 - " About 33% of septic abortion cases presented with generalized peritonitis, septicemia, septic shock, acute renal failure, or disseminated intravascular coagulation (DIC). " 12/01/1987 - "The effect of a serine proteinase inhibitor on DIC in septic abortion."
9.	Clindamycin (Cleocin)FDA LinkGeneric 11/01/2013 - "To compare the rates of cure of septic abortion and pelvic inflammatory disease using a daily dose of clindamycin with gentamicin versus divided doses, we conducted a retrospective cohort study, where the electronic records of 661 patients who used clindamycin 1 × , 3 × or 4 ×/day (groups 1, 3 and 4, respectively) between September 2002 and August 2010 were analysed. " 01/01/1991 - "Clindamycin (alone or with an aminoglycoside) has been used successfully in posthysterectomy vaginal cuff infections and, with an aminoglycoside, in septic abortions. " 07/01/2016 - "We found no strong evidence that intravenous clindamycin alone was better than penicillin plus chloramphenicol for treating women with septic abortion. " 01/01/1985 - " Among 30 febrile patients with diagnoses of septic abortion, 14 were treated with penicillin/gentamycin and 16 with clindamycin/gentamycin. " 01/01/1985 - " Although the combination of penicillin and gentamycin has given excellent results, the high incidence of Bacteroides fragilis and other anerobics in septic abortion prompted a comparison of penicillin and gentamycin with clindamycin and gentamycin at the Hospital Santo Tomas in Panama City, Panama, beginning in May 1984. "
10.	EnzymesIBA 04/01/2009 - "Direct cause was led by infections (n=23, 27.7%): 15 septic abortions (two [2.4%] spontaneous and 13 [15.6%] induced; seven of these occurred in 1997-2001); along with seven (8.6%) cases of puerperal sepsis; a case of antenatal septic shock; and a case of hemolysis, elevated liver enzyme levels, and low platelet count syndrome. " 12/01/2019 - "Septic abortion, hyperemesis gravidarum, and hemorrhage have become less prevalent with access to healthcare but are being displaced by thrombotic microangiopathies, such as preeclampsia, hemolysis, elevated liver enzymes, low platelets syndrome, thrombotic thrombocytopenic purpura, and pregnancy-associated hemolytic-uremic syndromes, as well as acute fatty liver of pregnancy. " 11/01/1969 - "[Tetracycline-enzymes in septic abortion]." 10/01/2009 - "Postpartum haemorrhage was present in 14 (23.33%), postpartum haemorrhage and disseminated intravascular coagulation (DIC) in 11 (18.33%), eclampsia-preeclampsia in 8 (13.33%), antepartum haemorrhage in 8 (13.33%), antepartum haemorrhage with DIC in 6 (10%), DIC alone in 4 (6.66%), obstructed labour in 3 (5%), septic abortion in 3 (3.33%), HELLP (haemolysis elevated liver enzyme and low platelet) in 2 (3.33%), urinary tract infection with sepsis in 1 (1.66%) and puerperal sepsis in 1 (1.66%). " 10/01/2015 - "Obstetrical DIC has been associated with a series of pregnancy complications including the following: (1) acute peripartum hemorrhage (uterine atony, cervical and vaginal lacerations, and uterine rupture); (2) placental abruption; (3) preeclampsia/eclampsia/hemolysis, elevated liver enzymes, and low platelet count syndrome; (4) retained stillbirth; (5) septic abortion and intrauterine infection; (6) amniotic fluid embolism; and (7) acute fatty liver of pregnancy. "

Therapies and Procedures

1.	Therapeutics 10/01/2001 - "Advances in diagnostic techniques and therapy and the institution of both legislative measures and Centres for the protection of mother-infant health are major factors to which the reduced incidence of septic abortion in should probably be ascribed in Western Countries, where it reaches approximately 10%. " 12/01/1951 - "Further studies with ultraviolet blood irradiation therapy (Knott technic) in septic abortions." 01/01/1968 - "[Clinical aspects and therapy of septic abortions]." 01/01/1971 - "[Modern therapy of endotoxic shock in septic abortion]." 07/01/1996 - "Acute renal failure occurred in association with antepartum hemorrhage in 15, postpartum hemorrhage in 10, intrauterine death of fetus in 11, preeclampsia or eclampsia in 9, and septic abortions or puerperal sepsis in 7. Thirty-six patients required dialysis therapy because of moderate to severe azotemia. "
2.	Contraception (Birth Control) 12/01/1995 - " In many parts of China, abortion is used as a method of birth control, and thousands of women die each year from septic abortions. " 02/01/1995 - " No septic abortion case had used contraception. " 06/01/1979 - " Preventive contraception would alleviate most of the potential dangers of septic abortion." 01/01/1974 - " In the question period the speakers recommended no particular precautions for cases of medical abortion, oral contraception, nulliparas, normal caesarean sections, but in cases of septic abortion, very young nulliparas or complicated caesarean section, careful judgement in needed when inserting IUDs." 08/04/1994 - " Primary prevention of septic abortion encompasses the provision of effective contraception, provision of safe and legal abortion in cases of contraceptive failure, and appropriate medical management of abortion. "
3.	Legal Abortion (Legal Abortions) 07/01/1981 - "Singapore's liberal abortion laws have led to a marked decrease in morbidity and mortality from septic abortion; motality from legal abortion is very low. " 01/01/1985 - " As legal abortions became widely available, the numbers of women treated for septic abortion complications in emergency rooms and hospitals decreased markedly. " 02/01/1973 - "The effect of legal abortion on the rate of septic abortion at a large county hospital." 08/04/1994 - " Primary prevention of septic abortion encompasses the provision of effective contraception, provision of safe and legal abortion in cases of contraceptive failure, and appropriate medical management of abortion. " 04/01/1988 - "These include better antenatal and intrapartum care, contraception for women who want no more pregnancies, legal abortion to terminate unwanted pregnancies, and uterine aspiration and antibiotics for treatment of septic abortion. "
4.	Hysterectomy 02/01/1979 - " The author cites 3 clinical studies, including a total abdominal hysterectomy, a septic abortion, and an IUD perforation, which responded to this treatment." 09/17/2018 - "[Septic abortion with massive coagulopathy and subsequent acute hysterectomy]." 04/01/2015 - "Initiation of a second-trimester termination procedure with lethal fetal injection resulted in subsequent septic abortion necessitating abdominal hysterectomy. " 03/01/2001 - "Complication of pregnancy still accounted for a high percentage of hysterectomy (11%) Most were ante-partum and post partum haemorrhages as well as septic abortion in young women Ten of the specimens were normal both grossly and microscopically. " 09/17/1988 - "It is concluded that ovaries which appear normal at hysterectomy for septic abortion should be conserved."
5.	Curettage 11/01/1964 - "[Clinical and bacteriological study of uterine curettage in septic abortion as the provoking agent of bacteremia]." 10/01/1997 - "In the expectant group, complications included missed abortion, septic abortion, and incomplete abortion requiring emergency curettage, with one patient requiring a transfusion. " 04/01/1992 - "The American Heart Association does not recommend prophylactic antibiotics for patients undergoing dilation and curettage (D & C) except in the case of septic abortion or the presence of prosthetic valves. " 01/01/1976 - "Amikacin, 500 mg intramuscularly every twelve hours, was used concomitantly with uterine curettage and fluid and electrolyte restoration in thirty septic abortion patients. "