Congenital Abnormalities (Deformity)

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9308 relevant articles (370 outcomes, 564 trials/studies) found for this Disease

Description: Malformations of organs or body parts during development in utero.

Also Known As:

Deformity; Birth Defects; Deformities; Birth Defect; Congenital Defect; Defects, Congenital; Congenital Abnormality; Abnormalities, Congenital; Defect, Congenital; Congenital Defects; Abnormality, Congenital; Defect, Birth; Defects, Birth

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Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Hallux Valgus (Bunion)
3.	Flatfoot (Flat Feet)
4.	Neural Tube Defects (Exencephaly)
5.	Cerebral Palsy (Spastic Diplegia)
947 Diseases and 3685 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Experts

1.	Czeizel, A E: 8 articles (01/2008 - 11/2000)
2.	Bridwell, Keith H: 7 articles (09/2008 - 09/2003)
3.	Sørensen, H T: 7 articles (01/2008 - 03/2001)
4.	Czeizel, Andrew E: 6 articles (02/2008 - 01/2003)
5.	Olsen, J: 6 articles (01/2008 - 03/2001)
6.	Lenke, Lawrence G: 5 articles (11/2007 - 09/2003)
7.	Rockenbauer, M: 5 articles (07/2004 - 03/2001)
8.	Tsuchiya, Hiroyuki: 4 articles (10/2008 - 09/2002)
9.	Tomita, Katsuro: 4 articles (10/2008 - 09/2002)
10.	Sakurakichi, Keisuke: 4 articles (10/2008 - 09/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital Abnormalities:

1.	CosmeticsIBA 07/01/2001 - "However, there was no spontaneous improvement in the deformity in older patients; most of the NOP patients continued to show a cosmetic deformity and 26.7% had psychological problems" 12/01/1989 - "By combining early detection and modern management techniques, significant untreated curvature of the spine can be eliminated, and functional and cosmetic deformity can be avoided." 05/01/1983 - "Surgical treatment can produce good results, but equally satisfactory function with minimal residual cosmetic deformity may be achieved by nonsurgical measures." 06/01/1979 - "Repair is recommended for patients in late adolescence due to the cosmetic nature of the procedure, the apparent lack of an associated postural deformity and the good results of operation in this age group." 08/01/1978 - "This technique, while effective in maintaining the line in situ, is fraught with hazards of chronic erosion at both exits sites, with significant cosmetic deformity, necessitated by the taped external line and, in the pediatric age group, with frequent harassment by peers and siblings pulling the exposed line" Get all the results and reference details, order at left...
2.	Folic Acid (Vitamin M)FDA LinkGeneric 06/15/2005 - "Based upon suggestive evidence that periconceptional folic acid supplementation is effective in preventing a significant proportion of the aforementioned birth defects, genetic variation in the folate biosynthetic pathways may influence the infant's susceptibility to these birth defects" 11/01/2000 - "Furthermore, it would require changes to the previous recommendations since a multivitamin containing a physiological dose of folic acid (0.5 to 0.8mg) seems to be more effective in reducing the occurrence of the first NTD and other congenital abnormalities than folic acid alone" 01/01/2008 - "CONCLUSION: The results indicate that the risk of congenital abnormalities in children exposed in utero to CBZ, PB, PHT, and PRI is reduced but not eliminated by folic acid supplementation at 5-12 weeks from LMP" 04/01/1989 - "Supplementation of the deficient serum with folic acid improved growth and greatly reduced the occurrence of deformities" 11/01/2007 - "OBJECTIVES: This study had two purposes: first, to determine the knowledge, attitudes, and practices related to folic acid and birth defects among a convenience sample of postpartum Honduran women; and second, to identify food consumption patterns in this population and determine high-consumption staples for potential folic acid fortification" Get all the results and reference details, order at left...
3.	daminozide (Alar)IBA 07/01/2007 - "CONCLUSION: This personal technique of nasal alar suturing during bimaxillary surgery appears to be effective in avoiding unaesthetic deformities of the nasal base as well as providing good facial harmony." 11/01/2006 - "RESULTS: The postoperative results showed a significant statistical improvement in the following tip deformities: underprojected tip (P<.001), poorly defined tip (P<.001), alar retraction (P<.001), alar pinch (P<.001), overrotated tip (P<.001), and tip ptosis (P<.01)" 10/01/2001 - "Good results were obtained in 29 patients where alar-columellar web deformities were either absent or minimal and a satisfactory symmetry of the nostrils was achieved" 11/01/2007 - "The authors of this study describe a case of nasal alar deformity with a secondary deficiency of cartilage, treated with a advancement flap" 11/01/2007 - "The authors of this study describe a case of nasal alar deformity with a congenital deficiency of cartilage treated with a rotation flap" Get all the results and reference details, order at left...
4.	PlasticsIBA 11/01/2001 - "This study presents a practical classification that permits the plastic surgeon to critically evaluate which is the best option to correct abdominal deformities considering specific areas of myoaponeurotic weakness." 09/01/2001 - "This study presents a practical classification that permits the plastic surgeon to critically evaluate which is the best option to correct abdominal deformities considering specific skin and subcutaneous deformities." 06/01/1997 - "Spontaneous resolution of deformities after excision of facial skin lesions has been known and used for a long time by plastic surgeons" 07/01/1960 - "Surgical-psychiatric study of patients seeking plastic (cosmetic) surgery: ninety-eight consecutive patients with minimal deformity." 10/01/2008 - "Only when the radiograph was reviewed was a subtle plastic bowing deformity of the ulna seen" Get all the results and reference details, order at left...
5.	FlexorIBA 02/01/2006 - "The authors have found the flexor muscle slide the best treatment option for mild and moderate deformity" 11/01/2008 - "In one patient flexor pulley reconstruction was necessary in order to correct a bowstring deformity" 10/01/2008 - "A case of congenital flexion deformity of the long, ring, and little fingers with an aberrant origin of the flexor digitorum profundus is described" 10/01/2008 - "Congenital flexion deformity of the long, ring, and little fingers with an aberrant origin of the flexor digitorum profundus: case report." 09/01/2008 - "The deformities were corrected by lengthening the flexor hallucis longus and the flexor digitorum longus" Get all the results and reference details, order at left...
6.	Vitamin D FDA LinkGeneric 01/01/1982 - "Previously recommended treatment programs of high doses of vitamin D have effected some roentgenographic improvement in the rachitic lesions, but no related increase in height or severity of deformities has been associated with significant complications resulting from vitamin D toxicity" 10/01/1980 - "Treatment from early childhood with oral phosphate and vitamin D improved the rate of growth and controlled the progression of bowleg deformity" 10/01/1988 - "Histomorphometry and vitamin D metabolism of valgus-varus deformity in broiler chickens." 08/01/1984 - "If vitamin D requirements are not met during the physiological growth spurt, permanent pelvic deformity may result" 02/21/1976 - "A case of cervical deformity of lambs following dosage with vitamin D was investigated" Get all the results and reference details, order at left...
7.	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 05/01/2001 - "In such a population, increased folate intake may offer minimal protection against birth defects, whereas vitamin B12 administration should be considered" 06/01/2008 - "Starting pregnancy with an inadequate vitamin B12 status may increase risk of birth defects such as NTD, and may contribute to preterm delivery, although this needs further evaluation" 06/01/2008 - "CONCLUSION: The MTHFR 677C > T polymorphism in conjunction with reduced folate- and/or cobalamin status may increase the risk of complex birth defects." 06/01/2008 - "Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects." 01/01/2003 - "Folate, vitamin B12 and birth defects." Get all the results and reference details, order at left...
8.	Carbon MonoxideIBA 07/01/1997 - "More than half (56%) of the women who had fertility-conserving surgery and who have been in remission at least 2 years have become pregnant since the completion of EMA/CO, with 112 live births, including three infants with congenital abnormalities" 04/01/1998 - "56% of women who have been in remission for at least 2 years and had fertility conserving surgery have achieved pregnancy since completing EMA/CO and there have been 112 live births including 3 babies with congenital abnormalities" 06/01/2008 - "CONCLUSIONS: Delivery rates at co-located hospitals were high for mothers of infants with these correctable birth defects" 06/01/2008 - "OBJECTIVES: To determine the percentage of liveborn infants with selected antenatally identifiable and correctable birth defects who were delivered at hospitals with co-located paediatric surgical units (co-located hospitals)" 06/01/2008 - "Birth at hospitals with co-located paediatric units for infants with correctable birth defects." Get all the results and reference details, order at left...
9.	VitaminsIBA 05/01/1995 - "To study the relation of maternal periconceptional vitamin use to the risk of a congenital urinary tract anomaly (CUTA), we conducted a case-control study using the Washington State Birth Defect Registry" 11/01/2007 - "Birth defects were most often attributed to drug and alcohol use (20.6%) and lack of vitamin intake (18.1%), but 23.0% related defects to mystical, mythical, or religious causes" 07/01/2005 - "We compared women who used multivitamins three or more times per week with women who were not exposed to vitamins/cereals/supplements during the periconceptional period (3 months before pregnancy through the first trimester), adjusting for maternal age, education, race/ethnicity, first degree family history of a major birth defect, pre-pregnancy maternal body mass index, gravidity, and first trimester alcohol use and cigarette smoking" 09/01/2004 - "Optimizing vitamin status in the periconceptional period may reduce the rate of birth defects." 07/01/2004 - "Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines." Get all the results and reference details, order at left...
10.	Thalidomide (Thalomid)FDA Link 09/01/2005 - "Though several studies have been done on congenital malformations in India since the early 1960s, coinciding with the thalidomide tragedy in the West, no uniform methods are available for the surveillance of birth defects" 01/01/1977 - "In 1968 a study was made of the spinal changes in 32 children with multiple congenital abnormalities due to thalidomide" 07/01/2007 - "Thalidomide was first introduced in the 1950s, and its widespread use led to thousands of birth defects through the 1960s; it was quickly withdrawn from the market" 05/01/2007 - "Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway." 08/01/2006 - "Despite causing birth defects thalidomide is being used therapeutically to treat a number of diseases" Get all the results and reference details, order at left...
1287 Drugs and Important Bio-Agents and 4266 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

Therapies and Procedures

1.	Osteotomy 01/01/2005 - "CONCLUSIONS: Lamella and complex osteotomies of orbital rim and wall were proved to be save and effective for correction of most deformities of the orbital and periorbital region." 09/01/2003 - "CONCLUSIONS: Lamella and complex osteotomies of orbital rim and wall are proved to be safe and effective to correct most deformities of orbital and periorbital region and various kinds of orbital malposition." 01/01/1979 - "High tibial osteotomy is most effective in osteoarthritic knees with varus deformity, when correction is made to a femoro-tibial angle (standing) of 170 degrees (10 degrees valgus)." 05/01/1977 - "Our findings show that in excavatum deformities the best results were obtained by removing all deformed cartilage, mobilizing the sternum, using an anterior osteotomy, and stabilizing the chest with a metal strut (which was removed after one year)" 09/01/2008 - "Significant advances have been made in the contemporary management of thoracolumbar spinal deformities, including improved segmental bony fixation, techniques for osteotomy, and mechanically powerful reduction maneuvers, which now allow the spinal surgeon to correct severe, complex, and rigid spinal deformities" Get all the results and reference details, order at left...
2.	Arthrodesis 01/01/2005 - "Arthrodesis using an intramedullary nail with fins was effective for the treatment of severe deformity of the hind foot" 08/01/2003 - "SUMMARY OF BACKGROUND DATA: Combined anterior and posterior arthrodesis of the spine is useful in the management of fixed deformity involving the coronal and sagittal planes" 07/01/2005 - "Various studies have reported on the efficacy of anterior correction as opposed to posterior alone, whereas others have advocated a sequential, combined approach to diminish the degree of deformity and achieve solid arthrodesis" 09/15/2004 - "SUMMARY OF BACKGROUND DATA: The use of spinal instrumentation has been shown to improve curve correction and arthrodesis rates in spinal deformity surgery" 04/01/2000 - "The safety and efficacy of Isola-Galveston instrumentation and arthrodesis in the treatment of neuromuscular spinal deformities." Get all the results and reference details, order at left...
3.	Arthroplasty 08/01/2005 - "Total knee arthroplasty in ankylosed knees can achieve correction of deformity with a significant gain in range of motion and marked improvement in quality of life." 11/01/1998 - "A painful arthritic knee with severe valgus deformity may be treated successfully with total knee arthroplasty using several techniques: constrained implant with lateral release, nonconstrained implant with lateral release and a thick tibial insert, or nonconstrained implant with lateral release and medial reconstruction" 07/01/1981 - "MP joint arthroplasties performed in 33 joints gave fair results in 16 joints with fixed deformities and good results in 17 joints with passively correctable deformities" 11/01/2006 - "The stepwise algorithmic approach to treating fixed flexion deformity presented in this study in primary total knee arthroplasty is safe and effective." 11/01/2004 - "CONCLUSION: The implementation of dynamic spinal stabilization systems for fusionless correction of spinal deformity, dynamic posterior stabilization and total disc arthroplasty necessitates improved understanding with regard to spinal kinematics, patterns and mechanisms of histologic osseointegration and the neurohistopathologic response to particulate wear debris" Get all the results and reference details, order at left...
4.	Transplants (Transplant) 01/01/2006 - "CONCLUSIONS: Eyelid- and conjunctiva-sparing orbital exenteration with temporalis transfer and dermis-fat graft is a useful technique that minimizes the usual deformity and achieves good results" 01/01/1990 - "Autogenous grafts have been used successfully to treat the superior sulcus deformity, extruding implant, and the contracting socket" 10/01/1997 - "The iliac wedge graft was more effective for reduction of the deformity and initial stabilization" 01/01/1988 - "The result is (1) greater tip projection with fewer tip grafts, (2) improved correction of tip convexity, (3) fewer supratip deformities, and (4) fewer Weir excisions" 03/01/2006 - "BACKGROUND: Dorsal nasal contour can be improved by using fragmented or crushed cartilage grafts wrapped with fascia in patients with dorsal nasal deformities" Get all the results and reference details, order at left...
5.	Rhinoplasty 09/01/2005 - "A diagnosis of an aesthetic smiling deformity, which is functional rather than anatomic, is essential for provision of the best treatment in rhinoplasty" 03/01/1998 - "Aesthetic diagnosis of the smiling deformity, which is functional rather than anatomical, is essential to provide the best treatment in rhinoplasty" 09/01/2005 - "The authors' data showed that for the difficult bilateral cleft nasal deformity with significant tip flattening, the double-arch tip rhinoplasty provides improved nasal tip projection." 12/01/2006 - "PURPOSE: This study was undertaken to evaluate the efficacy of closed reduction of nasal fractures and determine the incidence of the need for post-traumatic septo-rhinoplasty in the management of residual nasal deformities" 01/01/1998 - "Correction of nasal tip deformities, especially bulbous tip deformities, has improved greatly with the advancement of open-approach rhinoplasty" Get all the results and reference details, order at left...
352 Therapies and Procedures and 5600 more articles analyzed in the Full Patient-Physician Summary Report, order at left...

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