MK-8825

Also Known As:

2-((8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro(4.5)dec-9-yl)-N-((6S)-2'-oxo-1',2',5,7-tetrahydrospiro(cyclopenta(b)pyridine-6,3'-pyrrolo(2,3-b)pyridin)-3-yl)acetamide

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - MK-8825: 4
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - MK-8825: 4
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - MK-8825: 4

Experts

1.	Bolay, Hayrunnisa: 1 article (01/2019)
2.	Boran, H Evren: 1 article (01/2019)
3.	Dilekoz, Ergin: 1 article (01/2019)
4.	Edvinsson, Lars: 1 article (01/2019)
5.	Eftekhari, Sajedeh: 1 article (01/2019)
6.	Filiz, Aslı: 1 article (01/2019)
7.	Tepe, Nermin: 1 article (01/2019)
8.	Akerman, Simon: 1 article (09/2015)
9.	Pardi, Vanessa: 1 article (09/2015)
10.	Romero-Reyes, Marcela: 1 article (09/2015)

Related Diseases

1.	Facial Pain (Myofacial Pain) 09/01/2015 - "In mice pre-treated with MK-8825 there is a significant reduction in these spontaneous orofacial pain behaviors. " 09/01/2015 - "A potent and selective calcitonin gene-related peptide (CGRP) receptor antagonist, MK-8825, inhibits responses to nociceptive trigeminal activation: Role of CGRP in orofacial pain."
2.	Migraine Disorders (Migraine) 07/01/2014 - "These data suggest that MK-8825 may represent a potential therapeutic tool for the treatment of migraine." 02/01/2015 - "Whether this also occurs with MK-8825, a novel anti-migraine drug also acting through CGRP receptor blockade (but chemically unrelated to olcegepant) was tested in the present study, which also investigated possible anti-neuroinflammatory effects of this drug. " 07/01/2014 - "The aim of this article is to test the analgesic effect of the CGRP receptor antagonist MK-8825 in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia. "
3.	Pain (Aches) 01/01/2019 - "CGRP receptor antagonist MK-8825 dose dependently attenuated CSD-induced trigeminal nerve mediated pain response without altering CSD waves and accompanied rCBF response. " 01/01/2019 - "CGRP receptor antagonist MK-8825 attenuates cortical spreading depression induced pain behavior." 07/01/2014 - "The aim of this article is to test the analgesic effect of the CGRP receptor antagonist MK-8825 in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia. "
4.	Hyperalgesia 02/01/2015 - "Acute as well as repeated (for 4 days) administration of MK-8825 (30-100 mg/kg, i.p.) significantly reduced CCI-ION-induced mechanical allodynia but was ineffective in CCI-SN rats. " 02/01/2015 - "CGRP receptor blockade by MK-8825 alleviates allodynia in infraorbital nerve-ligated rats." 07/01/2014 - "The aim of this article is to test the analgesic effect of the CGRP receptor antagonist MK-8825 in two animal models of pain that may be relevant for migraine: the tail flick test and the formalin test performed during NTG-induced hyperalgesia. "
5.	Myalgia 09/01/2015 - "Here we used a small molecule, selective CGRP receptor antagonist, MK-8825, to dissect the role of CGRP in inducing spontaneous nociceptive facial grooming behaviors, neuronal activation in the trigeminal nucleus, and systemic release of pro-inflammatory cytokines, in a mouse model of acute orofacial masseteric muscle pain that we have developed, as a surrogate of acute TMD. "

Related Drugs and Biologics

1.	Calcitonin Gene-Related Peptide Receptors (Calcitonin-Gene Related Peptide Receptor)
2.	olcegepant
3.	Calcitonin Gene-Related Peptide Receptor Antagonists
4.	Cytokines
5.	Calcitonin Gene-Related Peptide
6.	Formaldehyde (Formol)
7.	Analgesics (Analgesic Drugs)