1- (3,4- dihydro- 6,7- dimethoxy- 2(1H)- isoquinolinyl)- 3,3- dimethyl- 2- ((4- pyridinylmethyl)amino)- 1- butanone

a hypocretin receptor 2 antagonist

Also Known As:

(2S)-1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone hydrochloride; TCS OX2 29; TCSOX229

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone: 9
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-((4-pyridinylmethyl)amino)-1-butanone: 9

Experts

1.	Haghparast, Abbas: 3 articles (01/2021 - 01/2016)
2.	Karimi-Haghighi, Saeideh: 1 article (01/2021)
3.	Zargarani, Afsaneh: 1 article (01/2021)
4.	Alizadeh, Amir-Mohammad: 1 article (05/2019)
5.	Fazli-Tabaei, Soheila: 1 article (05/2019)
6.	Rezaee, Laleh: 1 article (05/2019)
7.	Salehi, Sakineh: 1 article (05/2019)
8.	Asadi, Saeedeh: 1 article (01/2018)
9.	Fereidoni, Masoud: 1 article (01/2018)
10.	Kordijaz, Elham: 1 article (01/2018)

Related Diseases

1.	Seizures (Absence Seizure) 01/01/2018 - "The purpose of this study was to evaluate the effect of Orx2 receptor antagonist (TCS OX2 29) on seizures and anxiety of PTZ-kindled rats. " 01/01/2018 - "Our results revealed that similar to valproate, administration of 7 µg/rat of TCS OX2 29 increased the latency period and decreased the duration time of 3rd and 4th stages of epileptiform seizures. " 02/01/2014 - "Our results revealed that treatment with SB334867 or TCS OX2 29 significantly prolonged the latency and reduced the duration of seizures, while also lowering the mortality rate in sleep-deprived rats exposed to pentylenetetrazol. "
2.	Pain (Aches) 12/01/2022 - "Neither SB334768 nor TCS OX2 29 alone affects pain-related behaviors in formalin tests. " 05/01/2019 - "Also, intrathecal administration of TCS OX2 29 alone (without stimulation of the LH) had no significant effect on formalin induced pain-related behaviors. " 01/01/2016 - "The findings showed that TCS OX2 29 administration dose dependently blocked carbachol-induced antinociception during both phases of formalin-induced pain. " 01/01/2016 - "Carbachol attenuated formalin-induced biphasic pain responses and SB-334867 or TCS OX2 29 administration dose-dependently antagonized the LH-induced analgesia during both phases. "
3.	Acute Pain 01/01/2021 - "Infusion of SB334867 or TCS OX2 29 in the CA1 impaired the analgesic consequences following chemical stimulation of the LH in acute pain. "
4.	Ganglion Cysts (Ganglion) 10/01/2015 - "Using whole-cell patch-clamp recordings in rat retinal slices, we demonstrated that orexin-A increased L-type-like barium currents (IBa,L) in ganglion cells (GCs), and the effect was blocked by the selective OX1R antagonist SB334867, but not by the OX2R antagonist TCS OX2 29. "
5.	Apnea 08/15/2014 - "Outcome was apnea rate/h during sleep-wake states at baseline and with an intracerebroventricular administration of vehicle, 4 nMol of agonist OB(DL), and 4 nMol of an antagonist, TCS OX2 29. "

Related Drugs and Biologics

1.	Formaldehyde (Formol)
2.	Carbachol (Carbastat)
3.	Valproic Acid (Depakote)
4.	Retinaldehyde (Retinal)
5.	Pentylenetetrazole (Metrazol)
6.	Barium
7.	Analgesics (Analgesic Drugs)
8.	Orexins
9.	1- (2- methylbenzoxazol- 6- yl)- 3- (1,5)naphthyridin- 4- yl urea

Related Therapies and Procedures

1.	Analgesia