human tumor-cells apoptosis factor

a hormone-peptide (MW about 6.8 kDa) with anti-cancer activity; cDNA of this protein is expressed mainly in the thymus and partially in the colon and in the frontal lobe of brain

Also Known As:

tumor-cells apoptosis factor, human; Nerofe; TCApF, human

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - human tumor-cells apoptosis factor: 2

Experts

1.	Braitbard, Ori: 1 article (01/2010)
2.	Devary, Orly: 1 article (01/2010)
3.	Devary, Yoram: 1 article (01/2010)
4.	Friedman, Zeev Y: 1 article (01/2010)
5.	Kass, Gideon: 1 article (01/2010)
6.	Ohana, Joel: 1 article (01/2010)
7.	Rubinstein, Ariel M: 1 article (01/2010)
8.	Sandler, Uziel: 1 article (01/2010)

Related Diseases

Neoplasms (Cancer)

01/01/2023 - "It was observed that the combination of Nerofe and DOX downregulated KRAS signaling via miR217 upregulation, resulting in enhanced apoptosis of tumor cells. "
01/01/2010 - "We report the isolation of a novel Tumor-Cells Apoptosis Factor (Nerofe). "
01/01/2023 - "Transformation of immunosuppressive mtKRAS tumors into immunostimulatory tumors by Nerofe and Doxorubicin."
01/01/2010 - "NEROFE--a novel human hormone-peptide with anti-cancer activity."
01/01/2023 - "In addition, the combination of Nerofe and DOX also resulted in activation of the immune system against tumor cells, manifested by an increase in the immunostimulatory cytokines IL-2 and IFN-γ as well as the recruitment of NK cells and M1 macrophages to the tumor site."

Related Drugs and Biologics

1.	Peptide Hormones (Polypeptide Hormones)
2.	Cytokines
3.	Interleukin-2 (IL2)
4.	Doxorubicin (Adriamycin)