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N- (3- (5- (4- bromo- 2- fluorophenylamino)- 3- cyclopropyl- 8- methyl- 2,4,7- trioxo- 3,4,7,8- tetrahydro- 2H- pyrido(2,3- d)pyrimidin- 1- yl)phenyl)methanesulfonamide

a protein kinase inhibitor and antineoplastic agent; structure in first source

Also Known As:

JTP 70902; JTP-70902; JTP70902

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - N-(3-(5-(4-bromo-2-fluorophenylamino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido(2,3-d)pyrimidin-1-yl)phenyl)methanesulfonamide: 2
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - N-(3-(5-(4-bromo-2-fluorophenylamino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido(2,3-d)pyrimidin-1-yl)phenyl)methanesulfonamide: 2
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - N-(3-(5-(4-bromo-2-fluorophenylamino)-3-cyclopropyl-8-methyl-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido(2,3-d)pyrimidin-1-yl)phenyl)methanesulfonamide: 2

Experts

1.	Sakai, Toshiyuki: 2 articles (08/2010 - 11/2007)
2.	Sowa, Yoshihiro: 2 articles (08/2010 - 11/2007)
3.	Horie, Naoyuki: 1 article (08/2010)
4.	Koto, Kazutaka: 1 article (08/2010)
5.	Kubo, Toshikazu: 1 article (08/2010)
6.	Matsui, Taka-Aki: 1 article (08/2010)
7.	Murata, Hiroaki: 1 article (08/2010)
8.	Sakabe, Tomoya: 1 article (08/2010)
9.	Tsuji, Yoshiro: 1 article (08/2010)
10.	Abe, Hiroyuki: 1 article (11/2007)

Related Diseases

1.	Fibrosarcoma 08/01/2010 - "Our results showed that JTP-70902 inhibits cell growth and induces cell cycle arrest in human Ras mutant fibrosarcoma cells. " 08/01/2010 - "In this study, we investigated the antitumor activity of JTP-70902, a novel specific MEK inhibitor, against human fibrosarcoma cells in which the ERK pathway is constitutively activated. "
2.	Neoplasms (Cancer) 11/01/2007 - "JTP-70902 suppressed the growth of most colorectal and some other cancer cell lines in vitro, and showed antitumor activity in an HT-29 xenograft model. " 08/01/2010 - "These results indicate that JTP-70902 might be an attractive compound for molecular-targeting chemotherapy for malignant soft tissue tumors with the activation of the Ras-MEK-ERK pathway."
3.	Colonic Neoplasms (Colon Cancer) 11/01/2007 - "Here we report the discovery of a novel pyrido-pyrimidine derivative, JTP-70902, which exhibits p15(INK4b)-inducing activity in p16(INK4a)-inactivated human colon cancer HT-29 cells. "

Related Drugs and Biologics

1.	Mitogen-Activated Protein Kinase Kinases (MEKs)
2.	pyrimidine

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)