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NVP-BSK805

Protein Kinase Inhibitors, JAK2 inhibitor; structure in first source

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - NVP-BSK805: 4

Experts

1.	Hou, Qiang: 1 article (01/2020)
2.	Hu, Zhaoyang: 1 article (01/2020)
3.	Hua, Yuhui: 1 article (01/2020)
4.	Jiang, Zhenzhen: 1 article (01/2020)
5.	Li, Ying: 1 article (01/2020)
6.	Wang, Weijia: 1 article (01/2020)
7.	Wu, Hongjin: 1 article (01/2020)
8.	Wu, Shixiu: 1 article (01/2020)
9.	Yang, Ling: 1 article (01/2020)
10.	Yue, Jing: 1 article (01/2020)

Related Diseases

1.	Polycythemia (Erythrocytosis) 01/01/2018 - "To test this, C57BL/6J chow-fed mice received either chronic intraperitoneal (ip) or repeated intracerebroventricular (icv) administration of the selective Jak2 inhibitor NVP-BSK805, which was proven efficacious in treating polycythemia in rodents. " 07/01/2010 - "Furthermore, NVP-BSK805 potently suppressed recombinant human erythropoietin-induced polycythemia and extramedullary erythropoiesis in mice and rats." 07/01/2010 - "Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805."
2.	Neoplasms (Cancer) 01/01/2020 - "After treatment with NVP-BSK805, ESCC cells showed decreased clonogenic survival and delayed tumor growth in vivo. " 01/01/2017 - "The JAK2 inhibitors CEP-33779 and NVP-BSK805 have high P-gp inhibitory activity and sensitize drug-resistant cancer cells to vincristine."
3.	Hyperphagia (Overeating) 01/01/2018 - "Consequently, acute icv administration of NVP-BSK805 at higher dose induced hyperphagia and body weight gain. "
4.	Body Weight (Weight, Body) 01/01/2018 - "Consequently, acute icv administration of NVP-BSK805 at higher dose induced hyperphagia and body weight gain. " 01/01/2018 - "Accordingly, acute icv administration of NVP-BSK805 prevented the ability of leptin to decrease food intake and body weight by impeding STAT3 phosphorylation within the hypothalamus. "
5.	Esophageal Squamous Cell Carcinoma 01/01/2020 - "NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo."

Related Drugs and Biologics

1.	Leptin
2.	Vincristine (Oncovin)
3.	Quinoxalines
4.	Phosphotransferases (Kinase)
5.	Erythropoietin
6.	CEP 33779

Related Therapies and Procedures

1.	Aftercare (After-Treatment)