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DFG peptide

Also Known As:

Asp-Phe-Gly; aspartyl-phenylalanyl-glycine

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - DFG peptide: 4

Experts

1.	Fu, Yu: 1 article (03/2017)
2.	Li, Zhonghuang: 1 article (03/2017)
3.	Wan, Shanhe: 1 article (03/2017)
4.	Wang, Guangfa: 1 article (03/2017)
5.	Wang, Yuanyuan: 1 article (03/2017)
6.	Wu, Xiaoyun: 1 article (03/2017)
7.	Zhang, Jiajie: 1 article (03/2017)
8.	Anuppalle, Mrudhula: 1 article (12/2013)
9.	Huh, Tae-Lin: 1 article (12/2013)
10.	Maddirevula, Sateesh: 1 article (12/2013)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2006 - "The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly (DFG) motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the specificity of the cancer drug imatinib, which is used to treat CML. " 10/01/2009 - "The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the specificity of the cancer drug imatinib, which is used to treat chronic myelogenous leukemia. "
2.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 10/01/2009 - "The recognition of an inactive conformation of Abl, in which a catalytically important Asp-Phe-Gly motif is flipped by approximately 180 degrees with respect to the active conformation, underlies the specificity of the cancer drug imatinib, which is used to treat chronic myelogenous leukemia. "
3.	Sarcoma (Soft Tissue Sarcoma) 03/29/2017 - "With the aim of discovering RAF inhibitors that bind to DFG-out inactive conformation created by the movement of Asp-Phe-Gly (DFG), we conducted structure-based drug design using the X-ray cocrystal structures of BRAF (v-raf murine sarcoma viral oncogene homolog B1), starting from bisarylurea derivative based on 1H-pyrazolo[3,4-d]pyrimidine scaffold 1a. "
4.	Hypoxia (Hypoxemia) 12/01/2013 - "Tribless family proteins are pseudokinases that lack DFG (Asp-Phe-Gly) motif in the functional kinase domain, regulating Akt and BMP pathways, insulin metabolism, hypoxia, and ubiquitination. "

Related Drugs and Biologics

1.	Imatinib Mesylate (Gleevec)
2.	Proteins (Proteins, Gene)
3.	Phosphotransferases (Kinase)
4.	Insulin (Novolin)
5.	pyrimidine