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2- (2- (4- bromophenyl)- 6- methylpyrimidin- 4- yl)aminoethanol

a GPR119 agonist; structure in first source

Also Known As:

AS 1269574; AS-1269574; AS1269574

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-yl)aminoethanol: 2
- Alcohols: 595
  - Ethanol: 23169
    - Ethanolamines: 16
      - 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-yl)aminoethanol: 2
  - Amino Alcohols: 20
    - Ethanolamines: 16
      - 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-yl)aminoethanol: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 2-(2-(4-bromophenyl)-6-methylpyrimidin-4-yl)aminoethanol: 2

Experts

1.	Chepurny, Oleg G: 1 article (06/2016)
2.	Holz, George G: 1 article (06/2016)
3.	Leech, Colin A: 1 article (06/2016)
4.	Roe, Michael W: 1 article (06/2016)
5.	Matsui, Tetsuo: 1 article (09/2010)
6.	Ohishi, Takahide: 1 article (09/2010)
7.	Shibasaki, Masayuki: 1 article (09/2010)
8.	Yoshida, Shigeru: 1 article (09/2010)

Related Diseases

1.

Type 2 Diabetes Mellitus (MODY)

09/24/2010 - "Taken together, these results suggest that AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes."
06/01/2016 - "Because we find that AS1269574 also acts in a conventional GPR119-mediated manner to stimulate proglucagon gene promoter activity in the GLUTag intestinal L cell line, new findings reported here reveal the surprising capacity of AS1269574 to act as a dual agonist at two molecular targets (GPR119/TRPA1) important to the control of L-cell function and type 2 diabetes mellitus drug discovery research. "

Related Drugs and Biologics

1.	Proglucagon (Glucagon Precursors)