|1.||Towner, Rheal A: 7 articles (10/2015 - 04/2010)|
|2.||Floyd, Robert A: 6 articles (09/2013 - 04/2010)|
|3.||Smith, Nataliya: 4 articles (10/2015 - 03/2013)|
|4.||Saunders, Debra: 4 articles (10/2015 - 07/2011)|
|5.||He, Ting: 4 articles (01/2015 - 04/2010)|
|6.||Lerner, Megan: 3 articles (10/2015 - 04/2010)|
|7.||Mamedova, Nadezda: 2 articles (10/2015 - 01/2015)|
|8.||Coutinho de Souza, Patricia: 2 articles (10/2015 - 01/2015)|
|9.||Meek, Bill: 2 articles (10/2015 - 01/2015)|
|10.||Njoku, Charity: 2 articles (10/2015 - 01/2015)|
01/01/2015 - "In a responsive cohort of treated animals, OKN-007 was able to significantly decrease tumor volumes (p<0.0001), increase survival (p<0.001), and increase diffusion (p<0.01) and perfusion rates (p<0.05). "
01/01/2015 - "OKN-007 was found to significantly decrease tumor volumes (p<0.05) and increase animal survival (p<0.05) in all OKN-007-treated mice compared to untreated animals. "
01/01/2015 - "Regarding treatment response, OKN-007 was also able to significantly decrease tumor volumes (P < 0.01) and increase survival (P < 0.001) in treated animals. "
03/01/2013 - "Furthermore, in vivo experiments verified that OKN-007 repressed tumor growth significantly. "
03/01/2013 - "To investigate the antitumor effect of OKN-007 in HCC, we treated Huh7 cells, which express high levels of SULF2, with OKN-007 and found that it significantly promoted tumor cell apoptosis and inhibited cell proliferation, viability, and migration. "
10/01/2015 - "Here, we report on the ability of an anticancer nitrone compound, OKN-007 [Oklahoma Nitrone 007; a disulfonyl derivative of α-phenyl-tert-butyl nitrone (PBN)] to decrease free radical levels in F98 rat gliomas using combined molecular magnetic resonance imaging (mMRI) and immunospin-trapping (IST) methodologies. "
10/01/2015 - "OKN-007 decreases free radical levels in a preclinical F98 rat glioma model."
03/01/2013 - "OKN-007 may be considered as a promising therapeutic addition or alternative for the treatment of aggressive human gliomas."
03/01/2013 - "U87 glioma volumes were found to significantly decrease (P < .05) after OKN-007 treatment, compared with untreated animals. "
07/15/2011 - "Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy."
|4.||Brain Neoplasms (Brain Tumor)
|5.||Glioblastoma (Glioblastoma Multiforme)
01/01/2015 - "Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts."
09/01/2013 - "The potential use of OKN-007 in combination with neurotropic compounds such as the lanthionine ketamine esters is discussed for glioblastoma multiforme as well as for various other indications leading to dementia, such as aging, septic shock, and malaria infections. "
|1.||disufenton sodium (NXY 059)
|2.||Caspase 3 (Caspase-3)
|3.||Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)
|4.||Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
|5.||Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)
|1.||Heterologous Transplantation (Xenotransplantation)