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S-(2,3-bis(palmitoyloxy)propyl)cysteine

binds and activates dendritic cells via interactinos with Toll like receptor 2 (TLR2); structure in first source

Also Known As:

Pam2Cys; dipalmitoyl-S-glyceryl cysteine

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Lipopeptides: 626
  - S-(2,3-bis(palmitoyloxy)propyl)cysteine: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Lipopeptides: 626
    - S-(2,3-bis(palmitoyloxy)propyl)cysteine: 5

Experts

1.	Jackson, David C: 3 articles (12/2018 - 07/2010)
2.	Zeng, Weiguang: 3 articles (12/2018 - 07/2010)
3.	Brown, Lorena E: 2 articles (09/2012 - 07/2010)
4.	Abkallo, Hussein M: 1 article (12/2018)
5.	Arakura, Yuka: 1 article (12/2018)
6.	Chua, Brendon: 1 article (12/2018)
7.	Culleton, Richard: 1 article (12/2018)
8.	Ernest, Medard: 1 article (12/2018)
9.	Haraga, Yohei: 1 article (12/2018)
10.	Hunja, Carol: 1 article (12/2018)

Related Diseases

1.	Human Influenza (Influenza) 09/04/2012 - "Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice." 07/01/2010 - "A conserved 15 amino-acid residue sequence of the ectodomain of the M2 protein of influenza A virus (M2e) induces a strong antibody (Ab) response when incorporated into a synthetic lipopeptide vaccine candidate containing a T-helper epitope from influenza A hemagglutinin and the dendritic cell-targeting lipid moiety S-[2,3-bis(palmitoyloxy)propyl]cysteine (Pam2Cys). "
2.	Infections 12/01/2018 - "Finally, PEG-Pam2Cys can reduce the numbers of mosquitoes that are infected, and the intensity of their infection, following blood feeding on gametocytaemic mice. " 09/04/2012 - "Pam2Cys treatment also reduced weight loss and lethality associated with virulent influenza virus infection in a Toll-like receptor-2-dependent manner. " 10/08/2022 - "No effect on virus infection nor the modulation of surface markers' expression (MHC I, MHC II DR, CD14, CD16, and CD163) were observed when Mag-Pam2Cys_P48 treated moMΦ were infected using a multiplicity of infection (MOI) of 1. Mag-Pam2Cys_P48 treated moMΦ released higher levels of IL-1α, IL-1β, IL-1Ra, and IL-18 in response to infection with NH/P68 ASFV compared to 26544/OG10-infected and mock-infected controls. "
3.	Weight Loss (Weight Reduction) 09/04/2012 - "Pam2Cys treatment also reduced weight loss and lethality associated with virulent influenza virus infection in a Toll-like receptor-2-dependent manner. "
4.	Virus Diseases (Viral Diseases) 10/08/2022 - "No effect on virus infection nor the modulation of surface markers' expression (MHC I, MHC II DR, CD14, CD16, and CD163) were observed when Mag-Pam2Cys_P48 treated moMΦ were infected using a multiplicity of infection (MOI) of 1. Mag-Pam2Cys_P48 treated moMΦ released higher levels of IL-1α, IL-1β, IL-1Ra, and IL-18 in response to infection with NH/P68 ASFV compared to 26544/OG10-infected and mock-infected controls. "
5.	Malaria 12/01/2018 - "The activity of PEG-Pam2Cys against the hepatocytic stages, erythrocytic stages and gametocytes of the rodent malaria parasite Plasmodium yoelii was investigated in laboratory mice. " 12/01/2018 - "We show that administration of PEG-Pam2Cys, a soluble form of the TLR2 agonist S-[2,3-bis(palmitoyloxy)propyl] cysteine (Pam2Cys), significantly and dramatically reduces the numbers of malaria parasites that grow in the livers of mice following subsequent challenge with sporozoites. "

Related Drugs and Biologics

1.	Lipopeptides
2.	Cysteine (L-Cysteine)
3.	Interleukin 1 Receptor Antagonist Protein (Anakinra)
4.	Interleukin-18 (Interleukin 18)
5.	Vaccines
6.	Proteins (Proteins, Gene)
7.	Lipids
8.	Hemagglutinins (Hemagglutinin)
9.	Epitopes
10.	Amino Acids

Related Therapies and Procedures

1.	Intranasal Administration