1- (2- hydroxy- 1- phenylethyl)- 3- (4- (pyridin- 4- yl)phenyl)urea

structure in first source

Also Known As:

AS 1892802; AS-1892802; AS1892802

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - 1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - 1-(2-hydroxy-1-phenylethyl)-3-(4-(pyridin-4-yl)phenyl)urea: 3

Experts

1.	Shimizu, Yasuaki: 3 articles (01/2011 - 01/2010)
2.	Takeshita, Nobuaki: 3 articles (01/2011 - 01/2010)
3.	Yoshimi, Eiji: 3 articles (01/2011 - 01/2010)
4.	Hatori, Chie: 2 articles (01/2011 - 09/2010)
5.	Kumakura, Fumiyo: 2 articles (01/2011 - 09/2010)
6.	Seki, Nobuo: 1 article (01/2011)
7.	Hamachi, Emi: 1 article (09/2010)
8.	Ishii, Noe: 1 article (09/2010)
9.	Iwashita, Akinori: 1 article (09/2010)
10.	Terasawa, Takeshi: 1 article (09/2010)

Related Diseases

1.	Pain (Aches) 01/01/2011 - "AS1892802 prevents cartilage damage induced by MIA and has analgesic effects in rat pain models, suggesting that AS1892802 may be clinically useful for the treatment of OA.[Supplementary Figure: available only at http://dx.doi.org/10.1254/jphs.10319FP]." 01/01/2011 - "The effects of AS1892802, a selective Rho-associated coiled coil kinase (ROCK) inhibitor, on knee cartilage damage and pain behavior were examined in a rat model of osteoarthritis (OA). " 09/01/2010 - "These results suggest that AS1892802 has an attractive analgesic profile for the treatment of severe osteoarthritis pain."
2.	Arthritis (Polyarthritis) 09/01/2010 - "Orally administered AS1892802 exhibited potent antinociceptive effect in both an adjuvant-induced arthritis (AIA) model (inflammatory arthritis model) and a monoiodoacetate-induced arthritis (MIA) model (noninflammatory arthritis model), with an ED(50) of 0.15 mg/kg (MIA model). " 09/01/2010 - "In this study, antinociceptive effects of AS1892802 [1-[(1S)-2-hydroxy-1-phenylethyl]-3-[4-(pyridin-4-yl)phenyl]urea], a novel and highly selective ROCK inhibitor, were investigated in two rat models of arthritis. " 09/01/2010 - "Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis." 01/01/2010 - "To assess the pharmacological profile of AS1892802, a novel and selective Rho kinase (ROCK) inhibitor, we examined the effects of repeated dosing with AS1892802 on models of monoiodoacetate-induced arthritis and streptozotocin-induced neuropathy. "
3.	Osteoarthritis 01/01/2011 - "The effects of AS1892802, a selective Rho-associated coiled coil kinase (ROCK) inhibitor, on knee cartilage damage and pain behavior were examined in a rat model of osteoarthritis (OA). " 09/01/2010 - "These results suggest that AS1892802 has an attractive analgesic profile for the treatment of severe osteoarthritis pain."
4.	Chronic Pain 01/01/2010 - "These results suggest that peripheral ROCK plays a crucial role in chronic pain maintenance and that AS1892802 may be useful in treating chronic pain." 01/01/2010 - "Sustained analgesic effect of the Rho kinase inhibitor AS1892802 in rat models of chronic pain."

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Urea (Carbamide)
3.	rho-Associated Kinases
4.	Streptozocin (Streptozotocin)