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4- (2- (dimethylamino)vinyl)- 2- (3- hydroxyphenyl)- 6- morpholinopyrimidine- 5- carbonitrile

an mTOR inhibitor; structure in first source

Also Known As:

WJD 008; WJD-008; WJD008

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 4-(2-(dimethylamino)vinyl)-2-(3-hydroxyphenyl)-6-morpholinopyrimidine-5-carbonitrile: 2
  - Oxazines: 9
    - Morpholines: 6
      - 4-(2-(dimethylamino)vinyl)-2-(3-hydroxyphenyl)-6-morpholinopyrimidine-5-carbonitrile: 2

Experts

1.	Ding, Jian: 2 articles (09/2013 - 09/2010)
2.	Wang, Xiang: 2 articles (09/2013 - 09/2010)
3.	Li, Jia-peng: 1 article (09/2013)
4.	Meng, Ling-hua: 1 article (09/2013)
5.	Yang, Yan: 1 article (09/2013)
6.	Chen, Si-Meng: 1 article (09/2010)
7.	Li, Ting: 1 article (09/2010)
8.	Meng, Ling-Hua: 1 article (09/2010)
9.	Tong, Lin-Jiang: 1 article (09/2010)
10.	Wang, Jia: 1 article (09/2010)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 09/01/2013 - "In prostate cancer PC-3 cells, the PI3K isoform-selective inhibitors were much less potent than WJD008 in suppression of the proliferation. "
2.	Neoplasms (Cancer) 09/01/2010 - "In summary, WJD008 is a potent dual PI3K/mTOR modulator with antiproliferative and anticlonogenic activity in tumor cells and transformed cells with PIK3CA mutant, which provides new clues for the design and development of this chemical scaffold as an anticancer drug." 09/01/2010 - "WJD008 was superior to the pan-PI3K inhibitor wortmannin against proliferation of a panel of cancer cells independently of their status of PI3K pathway or tissue originations. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Wortmannin