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antrodin C

an antineoplastic agent isolated from Antrodia camphorata; structure in first source

Networked: 7 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Dicarboxylic Acids: 108
      - Maleates: 3
        Maleimides: 16
        antrodin C: 7
- Imides: 79
  - Maleimides: 16
    - antrodin C: 7
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Maleimides: 16
        antrodin C: 7

Experts

1.	Jia, Wei: 2 articles (03/2019 - 01/2019)
2.	Liu, Zhendong: 2 articles (03/2019 - 01/2019)
3.	Tang, Chuanhong: 2 articles (03/2019 - 01/2019)
4.	Wang, Wenhan: 2 articles (03/2019 - 01/2019)
5.	Yang, Hairui: 2 articles (03/2019 - 01/2019)
6.	Yang, Yan: 2 articles (03/2019 - 01/2019)
7.	Zhang, Henan: 2 articles (03/2019 - 01/2019)
8.	Wang, Sheng-Yang: 2 articles (11/2017 - 01/2015)
9.	Geng, Yan: 1 article (01/2022)
10.	Liu, Deng-Yang: 1 article (01/2022)

Related Diseases

1.	Amyloid Plaque 09/27/2021 - "EK100 and antrodin C improved the nesting behavior of mice, reduced the number and burden of amyloid plaques, reduced the activation of glial cells, and promoted the perivascular deposition of Aβ in the brain of mice. " 09/27/2021 - "Our data indicate that EK100 and antrodin C reduce the pathology of AD by reducing amyloid deposits and promoting nesting behavior in APPswe/PS1dE9 mice through microglia and perivascular clearance, indicating that EK100 and antrodin C have the potential to be used in AD treatment."
2.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2022 - "Antrodin C ameliorates the activation, migration, ECM production in HSCs and CCl4-induced liver fibrosis in mice, suggesting that Antrodin C could serve as a protective molecule against liver fibrosis." 01/01/2022 - "Antrodin C (3, 6 mg/kg/d) oral administration reduced the degree of liver fibrosis induced by CCl4 in mice. " 01/01/2022 - "The anti-fibrotic effect of Antrodin C was investigated in CFSC-8B cell (hepatic stellate cell) stimulated by transforming growth factor-β1 (TGF-β1) or platelet-derived growth factor-BB (PDGF-BB) in vitro and in CCl4 induced liver fibrosis in mice. " 01/01/2022 - "Antrodia camphorata-Derived Antrodin C Inhibits Liver Fibrosis by Blocking TGF-Beta and PDGF Signaling Pathways."
3.	Neoplasm Metastasis (Metastasis) 01/01/2015 - "In this study, we found that Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea health food product inhibits TGF-β1-induced EMT and breast cancer cell metastasis in vitro. " 01/01/2015 - "Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways."
4.	Breast Neoplasms (Breast Cancer) 01/01/2015 - "In this study, we found that Antrodin C (ADC), a maleimide derivative isolated from Antrodia cinnamomea health food product inhibits TGF-β1-induced EMT and breast cancer cell metastasis in vitro. " 01/01/2015 - "Antrodin C inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via suppression of Smad2/3 and β-catenin signaling pathways."
5.	Colorectal Neoplasms (Colorectal Cancer) 03/21/2023 - "However, the molecular mechanisms underlying the mode of action of antrodin C on cancer cells, especially in human colorectal cancer (CRC), remain unclear. " 03/21/2023 - "Antrodin C Isolated from Antrodia Cinnamomea Induced Apoptosis through ROS/AKT/ERK/P38 Signaling Pathway and Epigenetic Histone Acetylation of TNFα in Colorectal Cancer Cells."

Related Drugs and Biologics

1.	maleimide
2.	Caspase 3 (Caspase-3)
3.	Catenins
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Transforming Growth Factor beta (TGF-beta)
6.	NADP (NADPH)
7.	Histones (Histone)
8.	Antioxidants
9.	Becaplermin (PDGF-BB)

Related Therapies and Procedures

1.	Oral Administration