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1-(nitrooxymethyl)-2-(nitrooxy)ethyl 7- (3,5- dihydroxy- 2- (3- hydroxy- 5- phenylpentyl)cyclopentyl)- 5- heptenoate

an antihypertensive agent; structure in first source

Also Known As:

NCX 125; NCX-125; NCX125

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins F: 2
        1-(nitrooxymethyl)-2-(nitrooxy)ethyl 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate: 1
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Synthetic Prostaglandins: 823
    - Synthetic Prostaglandins F: 2
      - 1-(nitrooxymethyl)-2-(nitrooxy)ethyl 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate: 1
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Synthetic Prostaglandins: 823
        Synthetic Prostaglandins F: 2
        1-(nitrooxymethyl)-2-(nitrooxy)ethyl 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate: 1

Experts

1.	Bastia, Elena: 1 article (04/2010)
2.	Batugo, Minerva R: 1 article (04/2010)
3.	Borghi, Valentina: 1 article (04/2010)
4.	Carreiro, Samantha T: 1 article (04/2010)
5.	Chiroli, Valerio: 1 article (04/2010)
6.	Chong, Wesley K M: 1 article (04/2010)
7.	Gale, David C: 1 article (04/2010)
8.	Guzzetta, Massimiliano: 1 article (04/2010)
9.	Impagnatiello, Francesco: 1 article (04/2010)
10.	Jia, Liu: 1 article (04/2010)

Related Diseases

1.	Ocular Hypertension (Glaucoma, Suspect) 04/01/2010 - "NCX 125 lowered IOP to a greater extent compared with equimolar latanoprost in: (a) rabbit model of transient ocular hypertension (0.030% latanoprost, not effective; 0.039% NCX 125, Delta(max) = -10.6 + or - 2.3 mm Hg), (b) ocular hypertensive glaucomatous dogs (0.030% latanoprost, Delta(max)= -6.7 + or - 1.2 mm Hg; 0.039% NCX 125, Delta(max) = -9.1 + or - 3.1 mm Hg), and (c) laser-induced ocular hypertensive non-human primates (0.10% latanoprost, Delta(max) = -11.9 + or - 3.7 mm Hg, 0.13% NCX 125, Delta(max) = -16.7 + or - 2.2 mm Hg). "
2.	Glaucoma 04/01/2010 - "NCX 125 was synthesized and tested in vitro for its ability to release functionally active NO and then compared with core latanoprost for its intraocular pressure (IOP)-lowering effects in rabbit, dog, and nonhuman primate models of glaucoma. " 04/01/2010 - "A novel nitric oxide releasing prostaglandin analog, NCX 125, reduces intraocular pressure in rabbit, dog, and primate models of glaucoma."

Related Drugs and Biologics

1.	Synthetic Prostaglandins (Prostaglandin Analogues)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Latanoprost (Xalatan)

Related Therapies and Procedures

1.	Lasers (Laser)