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GW 583340

an antineoplastic agent; structure in first source

Also Known As:

GW-583340; GW583340

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - GW 583340: 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfones: 534
    - GW 583340: 2

Experts

1.	Chen, Haipeng: 1 article (08/2011)
2.	Cui, Binbin: 1 article (08/2011)
3.	Jin, Yinghu: 1 article (08/2011)
4.	Wang, Xishan: 1 article (08/2011)
5.	Yu, Zhiwei: 1 article (08/2011)
6.	Aird, Katherine M: 1 article (05/2010)
7.	Devi, Gayathri R: 1 article (05/2010)
8.	Ghanayem, Rami B: 1 article (05/2010)
9.	Lyerly, Herbert K: 1 article (05/2010)
10.	Peplinski, Sharon: 1 article (05/2010)

Related Diseases

1.	Colonic Neoplasms (Colon Cancer) 08/12/2011 - "In this study, using human colon adenocarcinoma HT29 and SW480 cells as research models, we compared the efficacy of four EGFR inhibitors in of EGFR-mediated pathways, including the novel irreversible inhibitor 324674, conventional reversible inhibitor AG1478, dual EGFR/HER2 inhibitor GW583340 and the pan-EGFR/ErbB2/ErbB4 inhibitor. "
2.	Neoplasms (Cancer) 05/01/2010 - "In the present study, using a clonal population of GW583340 (lapatinib analogue, ErbB1/2 inhibitor)-resistant IBC cells, we identified the overexpression of an antiapoptotic protein, X-linked inhibitor of apoptosis protein (XIAP), in acquired resistance to GW583340 in both ErbB2-overexpressing SUM190 and ErbB1-activated SUM149 cell lines derived from primary IBC tumors. "

Related Drugs and Biologics

1.	RTKI cpd
2.	X-Linked Inhibitor of Apoptosis Protein
3.	Proteins (Proteins, Gene)
4.	Lapatinib (GW572016)