HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

WP 1193

inhibits p-STAT3 signaling; structure in first source

Also Known As:

WP-1193; WP1193

Networked: 3 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Priebe, Waldemar: 3 articles (05/2012 - 01/2010)
2.	Colman, Howard: 2 articles (05/2012 - 01/2010)
3.	Fokt, Izabela: 2 articles (05/2012 - 05/2010)
4.	Lang, Frederick F: 2 articles (05/2012 - 01/2010)
5.	Aldape, Kenneth: 1 article (05/2012)
6.	Alfred Yung, W K: 1 article (05/2012)
7.	Balasubramaniyan, Veerakumar: 1 article (05/2012)
8.	Chen, Zhongping: 1 article (05/2012)
9.	Conrad, Charles: 1 article (05/2012)
10.	Dasgupta, Atreyi: 1 article (05/2012)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2012 - "To test the efficacy of WP1193 against GSCs, we then administrated WP1193 to GSCs isolated and expanded from multiple human GBM tumors. " 01/01/2010 - "The objective of this study was to probe perturbations of this loop in a glioblastoma cancer stem cell line (GSC11) derived from a human tumor by use of a JAK2/STAT3 phosphorylation inhibitor (WP1193), IL-6 stimulation, and hypoxia. "
2.	Melanoma (Melanoma, Malignant) 05/01/2010 - "We hypothesized that WP1193, a novel inhibitor of STAT3 signaling, would enhance the antitumor activity of IFN-alpha against metastatic melanoma. " 05/01/2010 - "IFN-alpha immunotherapy was synergistic with WP1193 showing marked in vivo efficacy against metastatic and established intracerebral melanoma. "
3.	Glioblastoma (Glioblastoma Multiforme) 05/01/2012 - "Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway." 01/01/2010 - "The objective of this study was to probe perturbations of this loop in a glioblastoma cancer stem cell line (GSC11) derived from a human tumor by use of a JAK2/STAT3 phosphorylation inhibitor (WP1193), IL-6 stimulation, and hypoxia. "
4.	Glioma (Gliomas) 05/01/2012 - "In the present study, we found that a novel Janus kinase 2/Signal Transducer and Activator of Transcription 3 (JAK2/STAT3) pathway inhibitor (WP1193) significantly decreased the proliferation of established glioma cell lines in vitro and inhibit the growth of glioma in vivo. "
5.	Hypoxia (Hypoxemia) 01/01/2010 - "The objective of this study was to probe perturbations of this loop in a glioblastoma cancer stem cell line (GSC11) derived from a human tumor by use of a JAK2/STAT3 phosphorylation inhibitor (WP1193), IL-6 stimulation, and hypoxia. "

Related Drugs and Biologics

1.	Janus Kinase 2
2.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
3.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Immunotherapy