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EPI 001

an antineoplastic agent and androgen receptor antagonist; structure in first source

Also Known As:

EPI-001; EPI001

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzhydryl Compounds
        EPI 001: 4
- Alcohols: 595
  - Chlorohydrins: 4
    - EPI 001: 4

Experts

1.	Bertoncini, Carlos W: 1 article (01/2016)
2.	Buzón, Victor: 1 article (01/2016)
3.	De Mol, Eva: 1 article (01/2016)
4.	Escobedo, Albert: 1 article (01/2016)
5.	Estébanez-Perpiñá, Eva: 1 article (01/2016)
6.	Fenwick, R Bryn: 1 article (01/2016)
7.	García, Jesús: 1 article (01/2016)
8.	McEwan, Iain J: 1 article (01/2016)
9.	Phang, Christopher T W: 1 article (01/2016)
10.	Riera, Antoni: 1 article (01/2016)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 12/16/2022 - "As an inhibitor of androgen receptor (AR), EPI-001 is being explored for the treatment of prostate cancer. " 01/01/2016 - "EPI-001, A Compound Active against Castration-Resistant Prostate Cancer, Targets Transactivation Unit 5 of the Androgen Receptor." 01/01/2023 - "Hybrid Androgen Receptor Inhibitors Outperform Enzalutamide and EPI-001 in in vitro Models of Prostate Cancer Drug Resistance." 02/28/2015 - "EPI-001 is a selective peroxisome proliferator-activated receptor-gamma modulator with inhibitory effects on androgen receptor expression and activity in prostate cancer." 01/01/2023 - "The compounds display an 18 to 53 fold improvement in the cell killing potency towards C4-2b prostate cancer (PCa) cells compared to the gold standards of therapy, enzalutamide and EPI-001. "
2.	Non-alcoholic Fatty Liver Disease 12/16/2022 - "This provides encouraging evidence for further studies on EPI-001 therapy for NAFLD." 12/16/2022 - "This study aimed to investigate the potential of EPI-001 for treating NAFLD in free fatty acids (FFAs)-induced human hepatic cells and high-fat-high-sugar (HFHS)-feeding mice. "
3.	Disease Progression 01/01/2016 - "EPI-001 is a recently identified compound active against this condition that modulates the activity of the androgen receptor, a nuclear receptor that is essential for disease progression. "

Related Drugs and Biologics

1.	Gold
2.	enzalutamide
3.	Nonesterified Fatty Acids (NEFA)
4.	Sugars
5.	Androgen Receptors (Androgen Receptor)
6.	PPAR gamma
7.	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)
8.	Solutions
9.	Androgens

Related Therapies and Procedures

1.	Therapeutics
2.	Castration